Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Adam Badar"'
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0140730 (2015)
The identification and engineering of proteins having refined or novel characteristics is an important area of research in many scientific fields. Protein modelling has enabled the rational design of unique proteins, but high-throughput screening of
Externí odkaz:
https://doaj.org/article/e2c2ed0e39a843a3b9c54f9bf1716fb1
Autor:
Adam Badar, Sarah DeFreitas, James M McDonnell, Norhakim Yahya, David Thakor, Reza Razavi, Richard Smith, Steven Sacks, Gregory E D Mullen
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18275 (2011)
We describe the design and synthesis of a new Tc-99m labeled bioconjugate for imaging activated complement, based on Short Consensus Repeats 1 and 2 of Complement Receptor 2 (CR2), the binding domain for C3d. To avoid non specific modification of CR2
Externí odkaz:
https://doaj.org/article/84e7b561fd86476baca4b36ec52ba480
Autor:
Philip J. Blower, Margaret S. Cooper, Jennifer D Williams, Gregory E. D. Mullen, Kevin Howland, Adam Badar, Florian Kampmeier
Publikováno v:
Bioconjugate Chemistry. 32:1242-1254
Hexahistidine tags (His-tags), incorporated into recombinant proteins to facilitate purification using metal-affinity chromatography, are useful binding sites for radiolabeling with [99mTc(CO)3]+ and [188Re(CO)3]+ for molecular imaging and radionucli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7158e874d2ed9bbc1718da7807eb3151
https://doi.org/10.1021/acs.bioconjchem.0c00561
https://doi.org/10.1021/acs.bioconjchem.0c00561
Autor:
Jennifer D, Williams, Florian, Kampmeier, Adam, Badar, Kevin, Howland, Margaret S, Cooper, Gregory E D, Mullen, Philip J, Blower
Publikováno v:
Bioconjug Chem
Hexahistidine tags (His-tags), incorporated into recombinant proteins to facilitate purification using metal-affinity chromatography, are useful binding sites for radiolabeling with [(99m)Tc(CO)(3)](+) and [(188)Re(CO)(3)](+) for molecular imaging an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f5d786e767257d70545eb10493b9e0d
https://pubmed.ncbi.nlm.nih.gov/33241692
https://pubmed.ncbi.nlm.nih.gov/33241692
Autor:
Vessela, Vassileva, Vineeth, Rajkumar, Mario, Mazzantini, Mathew, Robson, Adam, Badar, Surinder, Sharma, Erik, Årstad, Daniel, Hochhauser, Mark F, Lythgoe, Jane, Kinghorn, Geoffrey M, Boxer, Rosmund Barbara, Pedley
Publikováno v:
Journal of Nuclear Medicine. 56:1239-1245
Despite extensive efforts to improve the clinical management of patients with colorectal cancer, approved treatments for advanced disease offer limited survival benefit. Therefore, the identification of novel treatment strategies is essential. We eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91173a289fb8b470adb66c62ed994fb
https://doi.org/10.2967/jnumed.115.157362
https://doi.org/10.2967/jnumed.115.157362
Autor:
Amit C. Nathwani, Mark F. Lythgoe, Marco Della Peruta, Devhrut Nathwani, Erik Årstad, Cecilia Rosales, Eva Galante, Adam Badar, Shilpa Chokshi, Ran Yan, Roger Williams, Azadeh Kia, Andrew M. Davidoff
Publikováno v:
Human Gene Therapy. 26:94-103
A novel selectively targeting gene delivery approach has been developed for advanced hepatocellular carcinoma (HCC), a leading cause of cancer mortality whose prognosis remains poor. We combine the strong liver tropism of serotype-8 capsid-pseudotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0763f47c5909dbc8d8225a2a39d2bd46
https://doi.org/10.1089/hum.2014.052
https://doi.org/10.1089/hum.2014.052
Autor:
Ehsan Sharif-Paghaleh, Krisanat Chuamsaamarkkee, Florian Kampmeier, Richard A. G. Smith, Julia Baguña Torres, Sarah Lena Puhl, Philip J. Blower, Gregory E. D. Mullen, James Clark, Steven H. Sacks, May Lin Yap, Adam Badar
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-2 (2018)
Scientific Reports
Scientific Reports
Complement activation is a recognised mediator of myocardial ischaemia-reperfusion-injury (IRI) and cardiomyocytes are a known source of complement proteins including the central component C3, whose activation products can mediate tissue inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d6a6f81b6cc21887a3a97c0545aa73
http://link.springer.com/article/10.1038/s41598-018-22722-x
http://link.springer.com/article/10.1038/s41598-018-22722-x
Autor:
Erik Årstad, Adam Badar, Andrew Baxter, John F. Bower, Karl M. Cable, Michael A. Carroll, Melanie Y. T. Chan, Michael Charlton, Martin Christlieb, Bart Cornelissen, Liam R. Cox, Ben Davis, Jonathan R. Dilworth, Ethaar El-Emir, George J. Ellames, Eva Galante, Neil Geach, Antony D. Gee, Véronique Gouverneur, Thomas J. Gregson, David Hendry, Rebekka Hueting, Kamila Hussien, Tenzeela Ilyas, Daniel D. Jenkins, Veerle Kersemans, Eric Knagg, Matthias Koepp, Andrew D. Kohler, Joel A. Krauser, Guillaume G. Launay, William J. S. Lockley, Mark F. Lythgoe, Daniel P. Manthorpe, Andrew McEwen, Ruth J. Muschel, Mark F. Oldfield, Jan Passchier, R. Barbara Pedley, Vineeth Rajkumar, Christopher D. Reed, Mathew Robson, Stephen J. Roe, Jim J. Ryan, Kerstin Sander, Nick Shipley, Sean C. Smart, Neil Smith, Daniel W. Spurr, Keith R. Taylor, Matthew Tredwell, David M. Whitehead, Geoffrey Woolley, Ran Yan
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 56:50-63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2678f0102323fdd2d061d239eba19777
https://doi.org/10.1002/jlcr.3015
https://doi.org/10.1002/jlcr.3015
Autor:
Thomas Wanek, Florian Bauer, Brian Hutton, SP Johnson, David Dickens, Erik Årstad, Oliver Langer, Holger Stark, Tammy L. Kalber, Kjell Erlandsson, Johann Stanek, Lilia Weizel, Mark F. Lythgoe, Mathew Robson, Niral Patel, Elena Yiannaki, Eva Galante, Claudia Kuntner, Kerstin Sander, Matthias J. Koepp, Severin Mairinger, Adam Badar, Thibault Gendron, Tim Kottke
Publikováno v:
Journal of medicinal chemistry. 58(15)
Increased activity of efflux transporters, e.g., P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), at the blood-brain barrier is a pathological hallmark of many neurological diseases, and the resulting multiple drug resistance repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d2097eef19c4b588de162d4712aa70
https://pubmed.ncbi.nlm.nih.gov/26161456
https://pubmed.ncbi.nlm.nih.gov/26161456
Autor:
Adam, Badar, Louise, Kiru, Tammy L, Kalber, Amit, Jathoul, Karin, Straathof, Erik, Årstad, Mark F, Lythgoe, Martin, Pule
Publikováno v:
EJNMMI Research
Background In vivo imaging using genetic reporters is a central supporting tool in the development of cell and gene therapies affording us the ability to selectively track the therapeutic indefinitely. Previous studies have demonstrated the utility o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4193c86e7b96a6f2d3dbeabd1e473f11
https://pubmed.ncbi.nlm.nih.gov/25853023
https://pubmed.ncbi.nlm.nih.gov/25853023