7-Epiclusianone, a Benzophenone Extracted from Garcinia brasiliensis (Clusiaceae), Induces Cell Cycle Arrest in G1/S Transition in A549 Cells

Autor: Marisa Ionta, Guilherme A. Ferreira-Silva, Evandro L. Niero, Éderson D'Martin Costa, Adam A. Martens, Welton Rosa, Marisi G. Soares, Gláucia M. Machado-Santelli, João Henrique G. Lago, Marcelo H. Santos

Publikováno v: Molecules, Vol 20, Iss 7, Pp 12804-12816 (2015)

Lung cancer is the leading cause of cancer deaths in the world. Disease stage is the most relevant factor influencing mortality. Unfortunately, most patients are still diagnosed at an advanced stage and their five-year survival rate is only 4%. Thus,

Externí odkaz: https://doaj.org/article/f82467cb43ad4c79ba422b2f4443224e

Ureaplasma diversum and Its Membrane-Associated Lipoproteins Activate Inflammatory Genes Through the NF-κB Pathway via Toll-Like Receptor 4

Autor: Gláucia Maria Machado-Santelli, Jorge Timenetsky, Ellunny C. Queiroz, Guilherme Barreto Campos, Laís Ferraz Brito, Flávia S. Nascimento, Manoel N. Santos-Junior, Elaine Novaes Barbosa, Tassyo L. Da Silva, Bruno Lopes Bastos, Maysa Santos Barbosa, Letícia de Oliveira da Silva, Lucas Miranda Marques, Mariana Morais Teixeira, Clarissa Leal Silva e Souza, M. E. O. A. Assumpção, Adam A. Martens, Izadora S. Rezende, Adriano Francisco Siqueira, Ana Marcia Sá Guimarães, Lucas S.C. da Silva

Publikováno v: Frontiers in Microbiology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Microbiology, Vol 9 (2018)

Objectives:Ureaplasma diversum is a pathogen of cows that may cause intense inflammatory responses in the reproductive tract and interfere with bovine reproduction. The aims of this study were to evaluate the immune response of bovine blastocysts and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381fb2148fb05eb7d89c15b63de4b786
http://europepmc.org/articles/PMC6052353

Caracterização do gene CDK7 e análise de sua possível atuação nos endociclos de Rhynchosciara americana

Autor: Adam Arai Martens

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

CDKs são proteínas responsáveis pela ativação e progressão do ciclo celular e também apresentam função na ativação e alongamento na transcrição. Dentre elas, CDK7 atua em ambas as funções, fosforilando as CDKs do ciclo celular e fazend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ed7e03f69de25c7652023e0375e717
https://doi.org/10.11606/d.42.2012.tde-26072012-142501

The multiple facets of drug resistance: one history, different approaches

Autor: Paula Rezende-Teixeira, Bianca Rocha-Sales, Marcelo De Souza, Camila Lauand, Beatriz Araujo Cortez, Adam A. Martens, Marcel Shiniti Urabayashi, Evandro Luís de Oliveira Niero, Jorge Henrique Neves, Gláucia Maria Machado-Santelli

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly display resistance to chemotherapy, and this is the major obstacle to a better prognosis of patients. Frequently, literature presents studies in monolayer cell cultu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ab4f156f2cad63de89c7391c0197aa
https://doi.org/10.1186/1756-9966-33-37

Abstract 481: The role of jaspamide in the actin cytoskeleton of melanoma cells: The relation between migration and invasion

Autor: Michelle S. Menezes, Fábio Siviero, Evandro Luís de Oliveira Niero, Adam A. Martens, Gláucia Maria Machado-Santelli

Publikováno v: Cancer Research. 72:481-481

Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Metastasis is the leading cause of melanoma mortality. The metastatic cascade represents a multi-step process which includes several cellular and molecular processes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0eecae174d1c561257fc6446a063bd4a
https://doi.org/10.1158/1538-7445.am2012-481