Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Adam A. Margolin"'
Autor:
Burcu Gurun, Wesley Horton, Dhaarini Murugan, Biqing Zhu, Patrick Leyshock, Sushil Kumar, Katelyn T. Byrne, Robert H. Vonderheide, Adam A. Margolin, Motomi Mori, Paul T. Spellman, Lisa M. Coussens, Terence P. Speed
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract T cell receptor repertoires can be profiled using next generation sequencing (NGS) to measure and monitor adaptive dynamical changes in response to disease and other perturbations. Genomic DNA-based bulk sequencing is cost-effective but nece
Externí odkaz:
https://doaj.org/article/f072a81ae5e44edd9681ef3c1accf20e
Autor:
Anna Y. Lee, Adam D. Ewing, Kyle Ellrott, Yin Hu, Kathleen E. Houlahan, J. Christopher Bare, Shadrielle Melijah G. Espiritu, Vincent Huang, Kristen Dang, Zechen Chong, Cristian Caloian, Takafumi N. Yamaguchi, ICGC-TCGA DREAM Somatic Mutation Calling Challenge Participants, Michael R. Kellen, Ken Chen, Thea C. Norman, Stephen H. Friend, Justin Guinney, Gustavo Stolovitzky, David Haussler, Adam A. Margolin, Joshua M. Stuart, Paul C. Boutros
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract Background The phenotypes of cancer cells are driven in part by somatic structural variants. Structural variants can initiate tumors, enhance their aggressiveness, and provide unique therapeutic opportunities. Whole-genome sequencing of tumo
Externí odkaz:
https://doaj.org/article/fca34c67ffed4790a306c9523e251762
Autor:
Dorota H. Sendorek, Cristian Caloian, Kyle Ellrott, J. Christopher Bare, Takafumi N. Yamaguchi, Adam D. Ewing, Kathleen E. Houlahan, Thea C. Norman, Adam A. Margolin, Joshua M. Stuart, Paul C. Boutros
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-9 (2018)
Abstract Background The clinical sequencing of cancer genomes to personalize therapy is becoming routine across the world. However, concerns over patient re-identification from these data lead to questions about how tightly access should be controlle
Externí odkaz:
https://doaj.org/article/ab0b15f9663d47eca47e4595ae0cd171
Autor:
Takahiro Tsujikawa, Sushil Kumar, Rohan N. Borkar, Vahid Azimi, Guillaume Thibault, Young Hwan Chang, Ariel Balter, Rie Kawashima, Gina Choe, David Sauer, Edward El Rassi, Daniel R. Clayburgh, Molly F. Kulesz-Martin, Eric R. Lutz, Lei Zheng, Elizabeth M. Jaffee, Patrick Leyshock, Adam A. Margolin, Motomi Mori, Joe W. Gray, Paul W. Flint, Lisa M. Coussens
Publikováno v:
Cell Reports, Vol 19, Iss 1, Pp 203-217 (2017)
Here, we describe a multiplexed immunohistochemical platform with computational image processing workflows, including image cytometry, enabling simultaneous evaluation of 12 biomarkers in one formalin-fixed paraffin-embedded tissue section. To valida
Externí odkaz:
https://doaj.org/article/29a7b3ea556a43c78bede944b10a3c6b
Autor:
Eduardo Méndez, Christopher J. Kemp, Carla Grandori, Adam A. Margolin, Vijayakrishna K. Gadi, Justin Guinney, In S. Jang, Hallie A. Swan, Robert L. Diaz, Franz X. Schaub, Carlos L. Green, Michael C. Kao, Kay E. Gurley, Heuijoon Park, Russell D. Moser, Reid Shaw, Ryan M. Mitchell, Ryan S. Basom, Olga Nikolova, Chang Xu
Supplementary Table 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3adc4337ac7300d866bc0696cac37ac9
https://doi.org/10.1158/1078-0432.22465463
https://doi.org/10.1158/1078-0432.22465463
Autor:
Eduardo Méndez, Christopher J. Kemp, Carla Grandori, Adam A. Margolin, Wendell G. Yarbrough, Asel Biktasova, In Sock Jang, Kay E. Gurley, Christopher M. Schaupp, Luisa Angelica Lerma, James Annis, Michael Kao, Chang Xu, Russell Moser
Figure S4. Body weight of MK-1775 treated mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1211c377dbd3da8c36d2a805d42bd6
https://doi.org/10.1158/1078-0432.22447263.v1
https://doi.org/10.1158/1078-0432.22447263.v1
Autor:
Eduardo Méndez, Christopher J. Kemp, Carla Grandori, Adam A. Margolin, Vijayakrishna K. Gadi, Justin Guinney, In S. Jang, Hallie A. Swan, Robert L. Diaz, Franz X. Schaub, Carlos L. Green, Michael C. Kao, Kay E. Gurley, Heuijoon Park, Russell D. Moser, Reid Shaw, Ryan M. Mitchell, Ryan S. Basom, Olga Nikolova, Chang Xu
Supplementary Table 6, 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfbc74ba805c1178acf546320a4e72c
https://doi.org/10.1158/1078-0432.22465466
https://doi.org/10.1158/1078-0432.22465466
Autor:
Eduardo Méndez, Christopher J. Kemp, Carla Grandori, Adam A. Margolin, Vijayakrishna K. Gadi, Justin Guinney, In S. Jang, Hallie A. Swan, Robert L. Diaz, Franz X. Schaub, Carlos L. Green, Michael C. Kao, Kay E. Gurley, Heuijoon Park, Russell D. Moser, Reid Shaw, Ryan M. Mitchell, Ryan S. Basom, Olga Nikolova, Chang Xu
Supplementary Table 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617ab74e927b8b19ab47e92dfacd30e6
https://doi.org/10.1158/1078-0432.22465475.v1
https://doi.org/10.1158/1078-0432.22465475.v1
Autor:
Eduardo Méndez, Christopher J. Kemp, Carla Grandori, Adam A. Margolin, Wendell G. Yarbrough, Asel Biktasova, In Sock Jang, Kay E. Gurley, Christopher M. Schaupp, Luisa Angelica Lerma, James Annis, Michael Kao, Chang Xu, Russell Moser
Tables S18-20: Table S18. Secondary validation assay statistical analysis (absolute viability) Table S19. Differential viability and caspase 3/7 dependent apoptosis AUC of secondary validation assay Table S20. Statistical analysis summary differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89728d414cc39df0ebbae89c2701037d
https://doi.org/10.1158/1078-0432.22447248
https://doi.org/10.1158/1078-0432.22447248
Autor:
Eduardo Méndez, Christopher J. Kemp, Carla Grandori, Adam A. Margolin, Wendell G. Yarbrough, Asel Biktasova, In Sock Jang, Kay E. Gurley, Christopher M. Schaupp, Luisa Angelica Lerma, James Annis, Michael Kao, Chang Xu, Russell Moser
Purpose: To identify novel therapeutic drug targets for p53-mutant head and neck squamous cell carcinoma (HNSCC).Experimental Design: RNAi kinome viability screens were performed on HNSCC cells, including autologous pairs from primary tumor and recur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5715f9df69076ca82341e78f832fdb48
https://doi.org/10.1158/1078-0432.c.6521022
https://doi.org/10.1158/1078-0432.c.6521022