Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Adam A. Kraya"'
Autor:
Jennifer B. Shah, Dana Pueschl, Bradley Wubbenhorst, Mengyao Fan, John Pluta, Kurt D’Andrea, Anna P. Hubert, Jake S. Shilan, Wenting Zhou, Adam A. Kraya, Alba Llop Guevara, Catherine Ruan, Violeta Serra, Judith Balmaña, Michael Feldman, Pat J. Morin, Anupma Nayak, Kara N. Maxwell, Susan M. Domchek, Katherine L. Nathanson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Carriers of pathogenic BRCA1/2 variants have a higher risk of breast and ovarian cancers, which recur frequently. Here, the authors sequence primary and recurrent tumours of BRCA1/2 mutation carriers, finding PARP1 amplifications, differential BRCA2
Externí odkaz:
https://doaj.org/article/86e2b8acb27543e9aad8ac4d1b5b8463
Autor:
Kara N. Maxwell, Bradley Wubbenhorst, Brandon M. Wenz, Daniel De Sloover, John Pluta, Lyndsey Emery, Amanda Barrett, Adam A. Kraya, Ioannis N. Anastopoulos, Shun Yu, Yuchao Jiang, Hao Chen, Nancy R. Zhang, Nicole Hackman, Kurt D’Andrea, Robert Daber, Jennifer J. D. Morrissette, Nandita Mitra, Michael Feldman, Susan M. Domchek, Katherine L. Nathanson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Most tumours associated with germline BRCA1/BRCA2 loss of function mutations respond to DNA damaging agents, however, some do not. Herein, the authors identify that a subset of breast/ovarian tumors retain a normal allele, which is associated with de
Externí odkaz:
https://doaj.org/article/0f6f94b247c0462089e5fb392de747ba
Autor:
Katherine L. Nathanson, Robert H. Vonderheide, Susan M. Domchek, Anupma Nayak, Michael Feldman, Jennifer J.D. Morrissette, Nandita Mitra, Amanda Barrett, Nicole Lunceford, Liza M. Dorfman, Andrew J. Rech, John Pluta, Brandon M. Wenz, Bradley Wubbenhorst, Kara N. Maxwell, Adam A. Kraya
Purpose:Breast cancers with BRCA1/2 alterations have a relatively high mutational load, suggesting that immune checkpoint blockade may be a potential treatment option. However, the degree of immune cell infiltration varies widely, and molecular featu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252a400e8c962fb5517f877b6d9a0067
https://doi.org/10.1158/1078-0432.c.6527826
https://doi.org/10.1158/1078-0432.c.6527826
Autor:
Katherine L. Nathanson, Robert H. Vonderheide, Susan M. Domchek, Anupma Nayak, Michael Feldman, Jennifer J.D. Morrissette, Nandita Mitra, Amanda Barrett, Nicole Lunceford, Liza M. Dorfman, Andrew J. Rech, John Pluta, Brandon M. Wenz, Bradley Wubbenhorst, Kara N. Maxwell, Adam A. Kraya
Supplementary Figures S1-S4, Tables S4, S6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742de8fb763cbbc859afff863f907911
https://doi.org/10.1158/1078-0432.22471266
https://doi.org/10.1158/1078-0432.22471266
Autor:
Katherine L. Nathanson, Robert H. Vonderheide, Susan M. Domchek, Anupma Nayak, Michael Feldman, Jennifer J.D. Morrissette, Nandita Mitra, Amanda Barrett, Nicole Lunceford, Liza M. Dorfman, Andrew J. Rech, John Pluta, Brandon M. Wenz, Bradley Wubbenhorst, Kara N. Maxwell, Adam A. Kraya
Characteristics of breast cancers ascertained from Penn Medicine hospitals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b7d87e54549c0eddc947172cdbb861
https://doi.org/10.1158/1078-0432.22471260.v1
https://doi.org/10.1158/1078-0432.22471260.v1
Autor:
Jia-Ren Lin, Daniel P. Cahill, Keith T. Flaherty, Yu-An Chen, Gao Zhang, Alvin Shi, Martin A. Nowak, Donald P. Lawrence, Jackson Stocking, Manolis Kellis, Benchun Miao, Benjamin Izar, Shaolin Mei, Peter K. Sorger, David Liu, Avinash Das Sahu, Christopher Alvarez-Breckenridge, Gyulnara G. Kasumova, Ryan J. Sullivan, Tabea Moll, Emily J. Robitschek, Alexander Heyde, Denis Schapiro, Priscilla K. Brastianos, Christine G. Lian, Kevin Bi, Mai P. Hoang, Li Lun Ho, Shu Wang, Dennie T. Frederick, Eytan Ruppin, Katherine L. Nathanson, Adam A. Kraya, Meenhard Herlyn, Mohsen Malehmir, Tommy Kim, Tatyana Sharova, Riley Fadden, Eliezer M. Van Allen, Genevieve M. Boland
Publikováno v:
Nat Med
Despite initial responses1-3, most melanoma patients develop resistance4 to immune checkpoint blockade (ICB). To understand the evolution of resistance, we studied 37 tumor samples over 9 years from a patient with metastatic melanoma with complete cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff5a9714eeac1cc365e45ff88b597cf
https://doi.org/10.1038/s41591-021-01331-8
https://doi.org/10.1038/s41591-021-01331-8
Autor:
Joshua A. Shapiro, Krutika S. Gaonkar, Stephanie J. Spielman, Candace L. Savonen, Chante J. Bethell, Run Jin, Komal S. Rathi, Yuankun Zhu, Laura E. Egolf, Bailey K. Farrow, Daniel P. Miller, Yang Yang, Tejaswi Koganti, Nighat Noureen, Mateusz P. Koptyra, Nhat Duong, Mariarita Santi, Jung Kim, Shannon Robins, Phillip B. Storm, Stephen C. Mack, Jena V. Lilly, Hongbo M. Xie, Payal Jain, Pichai Raman, Brian R. Rood, Rishi R. Lulla, Javad Nazarian, Adam A. Kraya, Zalman Vaksman, Allison P. Heath, Cassie Kline, Laura Scolaro, Angela N. Viaene, Xiaoyan Huang, Gregory P. Way, Steven M. Foltz, Bo Zhang, Anna R. Poetsch, Sabine Mueller, Brian M. Ennis, Michael Prados, Sharon J. Diskin, Siyuan Zheng, Yiran Guo, Shrivats Kannan, Angela J. Waanders, Ashley S. Margol, Meen Chul Kim, Derek Hanson, Nicholas Van Kuren, Jessica Wong, Rebecca S. Kaufman, Noel Coleman, Christopher Blackden, Kristina A. Cole, Jennifer L. Mason, Peter J. Madsen, Carl J. Koschmann, Douglas R. Stewart, Eric Wafula, Miguel A. Brown, Adam C. Resnick, Casey S. Greene, Jo Lynne Rokita, Jaclyn N. Taroni
Publikováno v:
Cell Genomics. :100340
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89652592b6c5a4712b59717574bf135d
https://doi.org/10.1016/j.xgen.2023.100340
https://doi.org/10.1016/j.xgen.2023.100340
Autor:
Anahita Fathi Kazerooni, Adam A Kraya, Meen Chul Kim, Nastaran Khalili, Sherjeel Arif, Run Jin, Komal Rathi, Ariana Familiar, Rachel Madhogarhia, Debanjan Haldar, Sina Bagheri, Hannah Anderson, Ibraheem Salman Shaikh, Shuvanjan Haldar, Jeffrey B Ware, Arastoo Vossough, Philip B Storm, Adam C Resnick, Christos Davatzikos, Ali Nabavizadeh
Publikováno v:
Neuro-Oncology. 24:vii181-vii182
Understanding the immune microenvironment in pediatric low-grade glioma (pLGG) patients may help in identification of the patients who benefit from anti-tumor immunotherapies. However, surgical resection is not feasible for many pLGG tumors in certai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47bfc675c9cca9cd80ed90a9872af599
https://doi.org/10.1093/neuonc/noac209.692
https://doi.org/10.1093/neuonc/noac209.692
Autor:
Adam A. Kraya, Kara N. Maxwell, Monika A. Eiva, Bradley Wubbenhorst, John Pluta, Michael Feldman, Anupma Nayak, Daniel J. Powell, Susan M. Domchek, Robert H. Vonderheide, Katherine L. Nathanson
Publikováno v:
JCO Precis Oncol
PURPOSE Ovarian cancers can exhibit a prominent immune infiltrate, but clinical trials have not demonstrated substantive response rates to immune checkpoint blockade monotherapy. We aimed to understand genomic features associated with immunogenicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ae71ef6f172ec085d7f17999151dc2
https://europepmc.org/articles/PMC8982238/
https://europepmc.org/articles/PMC8982238/
Autor:
Adam A Kraya, Run Jin, Chao Zhao, Ariana Familiar, Philip B Storm, Kathryn Wellen, Adam C Resnick, Ali Nabavizadeh
Publikováno v:
Neuro-Oncology. 24:vii268-vii268
Glutamine transporters play an important role in supporting increased tumor nutritional demands, often through overexpression of the solute carrier (SLC) family of membrane transporters. We aimed to understand the relationship of SLC transporter expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d84b4572e8dd618247630b32bbb9eef7
https://doi.org/10.1093/neuonc/noac209.1034
https://doi.org/10.1093/neuonc/noac209.1034