Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Adam, Uzieblo"'
Autor:
Kramer James Bernard, M.C. Holt, Stephen Douglas Barrett, Chi S. Ho, James Paul O'malley, Thomas A. Owen, Adam Uzieblo, Fred L. Ciske, A.J. Stein, Joseph Michael Colombo, María Inés Morano, Bradlee David Germain, Andrei M. Kornilov
Publikováno v:
Journal of Medicinal Chemistry. 62:4731-4741
A series of small-molecule full agonists of the prostaglandin E2 type 4 (EP4) receptor have been generated and evaluated for binding affinity and cellular potency. KMN-80 and its gem-difluoro analog KMN-159 possess high selectivity relative to other
Autor:
Stephen D, Barrett, Melissa C, Holt, James B, Kramer, Bradlee, Germain, Chi S, Ho, Fred L, Ciske, Andrei, Kornilov, Joseph M, Colombo, Adam, Uzieblo, James P, O'Malley, Thomas A, Owen, Adam J, Stein, Maria I, Morano
Publikováno v:
Journal of medicinal chemistry. 62(9)
A series of small-molecule full agonists of the prostaglandin E
Autor:
Adam Uzieblo, Dirk M. Zajonc, Tan-Yun Cheng, Yanping Xu, Gregory W. Endres, Garrett C. Moraski, Catherine E. Costello, Jingdan Hu, D. Branch Moody, Marvin J. Miller, Andrew J. Walz, Anne Kasmar, David C. Young
Publikováno v:
Journal of Biological Chemistry. 284:25087-25096
Mycobacterium tuberculosis survival in cells requires mycobactin siderophores. Recently, the search for lipid antigens presented by the CD1a antigen-presenting protein led to the discovery of a mycobactin-like compound, dideoxymycobactin (DDM). Here
Development of Monoclonal Antibodies to the Malondialdehyde−Deoxyguanosine Adduct, Pyrimidopurinone1
Autor:
Norma H. Mahle, Naomi Eliezer, Lawrence J. Marnett, Cynthia L. Sevilla, Shawn M. O'Hara, Ryan J. Miller, Munetaka Nokubo, Adam Uzieblo, Carol A. Rouzer
Publikováno v:
Chemical Research in Toxicology. 10:172-180
Malondialdehyde (MDA), an endogenous product of lipid peroxidation and prostaglandin biosynthesis, is mutagenic in bacterial and mammalian cells and carcinogenic in rats. In order to determine whether MDA-modified bases are formed in nucleic acids in
Autor:
Paul J. Dobrowolski, Krishna C. Chimalakonda, Jeff Lapoint, Jeffery H. Moran, Cindy L. Moran, Lewis S. Nelson, Anna Radominska-Pandya, Laura P. James, Gregory W. Endres, Robert S. Hoffman, Paul D. Kennedy, Kim E. Fifer, Adam Uzieblo
Publikováno v:
Analytical chemistry. 83(16)
The aminoalkylindole agonists JWH-018 and JWH-073 are contained in "K2/SPICE" products sold as "legal marijuana". Previous human metabolic studies have identified (ω)-hydroxyl and (ω)-carboxyl metabolites as biomarkers that are indicative of produc
Autor:
Ting-Ting Yamin, Annie Zhao, Adam Uzieblo, John D. Menke, Yoko Hayashi, Young-Whan Park, Nancy S. Hayes, Yanfen Guan, Daniel Tew, Douglas K. Miller, Richard T. Cummings
Publikováno v:
Analytical biochemistry. 349(1)
Current immunoassays for the measurement of leukotriene B(4) (LTB(4)) typically utilize an enzyme-linked immunosorbent assay (ELISA) format that requires multiple incubations and washing steps and often expensive immunoassay kits. We have developed a