Echinocandins – structure, mechanism of action and use in antifungal therapy

Autor: Mateusz Szymański, Sandra Chmielewska, Urszula Czyżewska, Marta Malinowska, Adam Tylicki

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 876-894 (2022)

With increasing number of immunocompromised patients as well as drug resistance in fungi, the risk of fatal fungal infections in humans increases as well. The action of echinocandins is based on the inhibition of β-(1,3)-d-glucan synthesis that buil

Externí odkaz: https://doaj.org/article/3f66c7be2b0e4b40bffdc0a80ade60cd

Differences in the efficiency of 3-deazathiamine and oxythiamine pyrophosphates as inhibitors of pyruvate dehydrogenase complex and growth of HeLa cells in vitro

Autor: Ewa Grabowska, Magdalena Czerniecka, Urszula Czyżewska, Aneta Zambrzycka, Zenon Łotowski, Adam Tylicki

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 122-129 (2021)

Oxythiamine (OT) and 3-deazathiamine (DAT) are the antimetabolites of thiamine. The aim of study was to compare the effects of OT and DAT pyrophosphates (-PP) on the kinetics of mammalian pyruvate dehydrogenase complex (PDHC) and the in vitro culture

Externí odkaz: https://doaj.org/article/c88e70912c4842a6b8c37f36e8b31a9b

Differences in the efficiency of 3-deazathiamine and oxythiamine pyrophosphates as inhibitors of pyruvate dehydrogenase complex and growth of HeLa cells

Autor: Magdalena Czerniecka, Zenon Łotowski, Urszula Czyzewska, Adam Tylicki, Aneta Zambrzycka, Ewa Grabowska

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 122-129 (2021)

Oxythiamine (OT) and 3-deazathiamine (DAT) are the antimetabolites of thiamine. The aim of study was to compare the effects of OT and DAT pyrophosphates (-PP) on the kinetics of mammalian pyruvate dehydrogenase complex (PDHC) and the in vitro culture

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e169e83d1e8792de41d347ecb7b99b3e
https://pubmed.ncbi.nlm.nih.gov/33187452

Differences in protein profiles between

Autor: Urszula, Czyżewska, Justyna, Karkowska-Kuleta, Marek, Bartoszewicz, Magdalena, Siemieniuk, Aneta, Zambrzycka, Adam, Tylicki

Publikováno v: Mycologia. 111(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58f8baa09112a3a9e0481dd46e4b715b
https://pubmed.ncbi.nlm.nih.gov/31322986

Thiamine antivitamins - an opportunity of therapy of fungal infections caused byMalassezia pachydermatisandCandida albicans

Autor: Adam Tylicki, Slawomir Strumilo, Urszula Czyzewska, Magdalena Siemieniuk

Publikováno v: Mycoses. 59:108-116

Severe skin diseases and systemic fungaemia are caused by Malassezia pachydermatis and Candida albicans respectively. Antifungal therapies are less effective because of chronic character of infections and high percentage of relapses. Therefore, there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a519ccf4481832e1bad6aac1b4f53c06
https://doi.org/10.1111/myc.12441