Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Adam, Prahl"'
Spectroscopic characterization and in vitro studies of biological activity of bradykinin derivatives
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Eleven multiple analogs of bradykinin—a peptide that is a natural ligand of B1 and B2 receptors but does not bind or activate the B1 receptor unless Arg9 is removed from the sequence by the action of carboxypeptidase N—were synthesized.
Externí odkaz:
https://doaj.org/article/b1d5124492c2450b91d03e020ff76cca
Autor:
Oktawian Stachurski, Damian Neubauer, Aleksandra Walewska, Emilia Iłowska, Marta Bauer, Sylwia Bartoszewska, Karol Sikora, Aleksandra Hać, Dariusz Wyrzykowski, Adam Prahl, Wojciech Kamysz, Emilia Sikorska
Publikováno v:
Antibiotics, Vol 11, Iss 11, p 1491 (2022)
This study investigates short cationic antimicrobial lipopeptides composed of 2–4 amino acid residues and C12-C18 fatty acids attached to the N-terminal part of the peptides. The findings were discussed in the context of the relationship among biol
Externí odkaz:
https://doaj.org/article/4e52dadc452e4d59aaa562ae1072f563
Publikováno v:
Chemosensors, Vol 9, Iss 8, p 199 (2021)
Efficient deposition of biomolecules on the surface, maintaining their full activity and stability, is a most significant factor in biosensor construction. For this reason, more and more research is focused on the development of electrochemical biose
Externí odkaz:
https://doaj.org/article/94a9e9af70d440018558e5a4e38502bc
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9644
Colorectal cancer (CRC) is one of the most lethal malignancies worldwide, so the attempts to find novel therapeutic approaches are necessary. The aim of our study was to analyze how chemical modifications influence physical, chemical, and biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::a5f00206d5052dd1dad73563230bfe73
Autor:
Aleksandra Walewska, Paulina Kosikowska-Adamus, Marta Tomczykowska, Bartosz Jaroszewski, Adam Prahl, Grzegorz Bulaj
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12562
Human β-defensin 3, HBD-3, is a 45-residue antimicrobial and immunomodulatory peptide that plays multiple roles in the host defense system. In addition to interacting with cell membranes, HBD-3 is also a ligand for melanocortin receptors, cytokine r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e42e4b308f316143fc4dc8871c39392
https://pubmed.ncbi.nlm.nih.gov/36293413
https://pubmed.ncbi.nlm.nih.gov/36293413
Publikováno v:
Journal of Medicinal Chemistry
The article describes the application of the alanine-scanning technique used in combination with Raman, surface-enhanced Raman, attenuated total reflection Fourier transform infrared, and surface-enhanced infrared absorption (SEIRA) spectroscopies, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce4120f36ab44e30d5aba9c907b199d
https://doi.org/10.1021/acs.jmedchem.1c00397
https://doi.org/10.1021/acs.jmedchem.1c00397
Autor:
Kévin Ly, Hugo Gagnon, Pauline Navals, Yves L. Dory, Anna Kwiatkowska, Monika A Lewandowska-Goch, Adam Prahl, Teresa Łepek, Robert Day
Publikováno v:
ACS Med Chem Lett
Furin plays an important role in various pathological states, especially in bacterial and viral infections A detailed understanding of the structural requirements for inhibitors targeting this enzyme is crucial to develop new therapeutic strategies i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee64ddce4e872ccbea57dd6deeaf61e3
https://doi.org/10.1021/acsmedchemlett.0c00386
https://doi.org/10.1021/acsmedchemlett.0c00386
Autor:
Marta Makowska, Paulina Kosikowska-Adamus, Magdalena Zdrowowicz, Dariusz Wyrzykowski, Adam Prahl, Emilia Sikorska
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3951
Volume 24
Issue 4
Pages: 3951
In this paper, we describe the chemical synthesis, preliminary evaluation of antimicrobial properties and mechanisms of action of a novel group of lipidated derivatives of three naturally occurring α-helical antimicrobial peptides, LL-I (VNWKKVLGKII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa8a00e9a00480d7d9be985f1733ed4
https://doi.org/10.3390/ijms24043951
https://doi.org/10.3390/ijms24043951
Publikováno v:
Journal of Spectroscopy, Vol 2014 (2014)
Bradykinin (BK), an endogenous peptide hormone, which is involved in a number of physiological and pathophysiological processes, and the potent B2 bradykinin receptor antagonists, [D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, Aaa[D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, [D-Ar
Externí odkaz:
https://doaj.org/article/e3a2e354726c4c41b1c74efa316d76bc
Autor:
Alina Plenis, Piotr Kowalski, Tomasz Bączek, Adam Prahl, Natalia Kossakowska, Ilona Olędzka, Natalia Miękus
Publikováno v:
Talanta. 186:119-123
Nowadays, ionic liquids (ILs) are receiving more attention in various fields of analytical chemistry. Their contribution to the enhancement of the clean-up, extraction, separation and determination of trace amounts of various biologically important c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3532d8ee0cf01dd5600e150e9f54a51c
https://doi.org/10.1016/j.talanta.2018.04.041
https://doi.org/10.1016/j.talanta.2018.04.041