Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Adam, Ogden"'
Autor:
Nicholas DeMartinis, Rene N. Lopez, David P. Walling, Adam Ogden, Christopher J. Schmidt, Eve H. Pickering, Lev Gertsik
Publikováno v:
Journal of Clinical Psychopharmacology. 39:318-328
Background Effective treatments for managing suboptimal clinical responses to current therapy for schizophrenia remain a critical unmet need. Phosphodiesterase 10A (PDE10A) inhibition represents a mechanistically novel approach to the treatment of sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdce8e5a6aa25fb13e8af6b79286f5a
https://doi.org/10.1097/jcp.0000000000001047
https://doi.org/10.1097/jcp.0000000000001047
Publikováno v:
Clinical Pharmacology in Drug Development
Multiple‐dose pharmacokinetics (PK) and safety were investigated in this phase 1 study of PF‐06372865, a positive allosteric modulator of α2/3/5 subunit‐containing γ‐aminobutyric acid A receptors (NCT03351751). In 2 cohorts (7‐8 PF‐0637
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a01b9d10953ce8d42b607b262bc81f0
https://doi.org/10.1002/cpdd.912
https://doi.org/10.1002/cpdd.912
Autor:
Nicholas DeMartinis, Sanela Tarabar, Yiyun Huang, Anindita Banerjee, David Labaree, Shu-fei Lin, Nabeel Nabulsi, Rikki N. Waterhouse, Adam Ogden, Richard E. Carson, Mika Naganawa, Jim Ropchan
Publikováno v:
Journal of Nuclear Medicine. 57:1388-1395
This was a first-in-human study of the novel phosphodiesterase-2A (PDE2A) PET ligand 18F-PF-05270430. The primary goals were to determine the appropriate tracer kinetic model to quantify brain uptake and to examine the within-subject test–retest va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4de1dc300d141360515dde6463905f1
https://doi.org/10.2967/jnumed.115.166850
https://doi.org/10.2967/jnumed.115.166850
Autor:
Mihály Hajós, William E. Hoffman, John F. Harms, Mary Piotrowski, Christopher J. Schmidt, Eric P. Arnold, Robin J. Kleiman, Edward X. Yang, Adam Ogden, Patricia A. Seymour, Jiemin Lu, Ethan Lawrence Fisher, Nichole Vansell, Patrick Robert Verhoest, Jayvardhan Pandit, Zhijun Kang, Hirokazu Ueno, John M. Humphrey, Bethany L. Kormos, Dina McGinnis, Thomas Allen Chappie, Noha Maklad, Laura McDowell, Cheng Chang, Rebecca E. O’Connor, Chewah Lee, Tracey Boyden, Christopher J. O’Donnell, Christopher John Helal
Publikováno v:
Journal of medicinal chemistry. 61(3)
Computational modeling was used to direct the synthesis of analogs of previously reported phosphodiesterase 2A (PDE2A) inhibitor 1 with an imidazotriazine core to yield compounds of significantly enhanced potency. The analog PF-05180999 (30) was subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408cc7b21c310fe120ce681146fe8fb5
https://pubmed.ncbi.nlm.nih.gov/29293004
https://pubmed.ncbi.nlm.nih.gov/29293004
Autor:
Mary Anne Elder, Ye Tan, Gary Berman, Dmitri Volfson, Julie Brevard, Martin M. Bednar, Adam Ogden, Barbara Evans
Publikováno v:
Annals of Allergy, Asthma & Immunology. 117:433-435
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3addc5f35c8b5a6608db0434e80a075
https://doi.org/10.1016/j.anai.2016.07.026
https://doi.org/10.1016/j.anai.2016.07.026
Autor:
Ron Sarver, Christopher Whitehead, Heidi Baum, James Hicks, Richard Gowan, Brian Sanchez, Xiao Kang Lu, Susan E. Bove, Joseph A. Cornicelli, Howard Miller, Sandra Lightle, Aurash B Shahripour, Katherine Welch, Craig Banotai, Jayvardhan Pandit, Mark S. Plummer, Timothy Braden, David Beidler, Adam Ogden, Skalitzky Donald James, Annise Paige Goodman, Howard Roark, Nalini Sadagopan, Charles J. Stankovic, Cindy Spessard, Xi Qiang Shen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3438-3442
We identified potent, selective PDE2 inhibitors by optimizing residual PDE2 activity in a series of PDE4 inhibitors, while simultaneously minimizing PDE4 activity. These newly designed PDE2 inhibitors bind to the PDE2 enzyme in a cGMP-like mode in co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128c0eb423facb1ebd01be1c3f41f3b1
https://doi.org/10.1016/j.bmcl.2013.03.072
https://doi.org/10.1016/j.bmcl.2013.03.072
Autor:
Skalitzky Donald James, Craig Banotai, Jayvardhan Pandit, Adam Ogden, James Hicks, Annise Paige Goodman, Xiao Kang Lu, Howard Miller, Howard Roark, Susan E. Bove, Sandra Lightle, Aurash B Shahripour, Timothy Braden, Mark S. Plummer, Katherine Welch, Charles J. Stankovic, Ron Sarver, Joseph A. Cornicelli, Christopher Whitehead, Brian Sanchez, Nalini Sadagopan, Heidi Baum, Richard Gowan, David Beidler, Xi Qiang Shen, Cindy Spessard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3443-3447
Selective phosphodiesterase 2 (PDE2) inhibitors are shown to have efficacy in a rat model of osteoarthritis (OA) pain. We identified potent, selective PDE2 inhibitors by optimizing residual PDE2 activity in a series of phosphodiesterase 4 (PDE4) inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a8df19422ac729711863e191ea116e
https://doi.org/10.1016/j.bmcl.2013.03.082
https://doi.org/10.1016/j.bmcl.2013.03.082
Autor:
Ottavio V. Vitolo, Patrik Fazio, Nahid Amini, Marielle Delnomdedieu, Nabil Al-Tawil, Adam Ogden, Per Stenkrona, Sangram Nag, Sridhar Duvvuri, Anton Forsberg, Christer Halldin, William S. David, Ching-Ray Yu, Andrea Varrone
Publikováno v:
Neuropharmacology. 117
Phosphodiesterase 10A (PDE10A) is an enzyme highly enriched in the striatal medium spiny neurons. It is involved in the regulation of cytoplasmic levels of cAMP and cGMP and signaling within the basal ganglia. This study with PDE10A radioligand [18F]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8a7260e5dfd3019d5bda2a9e3ef5cf
https://pubmed.ncbi.nlm.nih.gov/28122201
https://pubmed.ncbi.nlm.nih.gov/28122201
Autor:
Julie, Brevard, Mary Anne, Elder, Gary, Berman, Ye, Tan, Dmitri, Volfson, Adam, Ogden, Barbara, Evans, Martin M, Bednar
Publikováno v:
Annals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology. 117(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de78c855208a854cfd0668432696f67e
https://pubmed.ncbi.nlm.nih.gov/27519579
https://pubmed.ncbi.nlm.nih.gov/27519579
Autor:
Adam Ogden, J. Richard Miller, Deqing Xiao, Michael Dority, Tong Zhu, Debra Hanna, Shawn Mehrens, Susan Buist, Michael Kuhn
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:124-129
The present study investigated the pharmacokinetic/pharmacodynamic (PK/PD) relationships of a prototype biotin carboxylase (BC) inhibitor, PD-0162819, against Haemophilus influenzae 3113 in static concentration time-kill (SCTK) and one-compartment ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9974f50054cd33cccb4868d4815baa
https://doi.org/10.1128/aac.00090-11
https://doi.org/10.1128/aac.00090-11