Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Adam, Noble"'
Autor:
James W. Mitchell, Adam Noble, Gus Baker, Rachel Batchelor, Francesco Brigo, Jakob Christensen, Jacqueline French, Antonio Gil-Nagel, Alla Guekht, Nathalie Jette, Reetta Kälviäinen, John Paul Leach, Melissa Maguire, Terence O’Brien, Felix Rosenow, Philippe Ryvlin, Phil Tittensor, Manjari Tripathi, Eugen Trinka, Samuel Wiebe, Paula R. Williamson, Tony Marson
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background A Core Outcome Set (COS) is a standardised list of outcomes that should be reported as a minimum in all clinical trials. In epilepsy, the choice of outcomes varies widely among existing studies, particularly in clinical trials. Th
Externí odkaz:
https://doaj.org/article/ea6743552dd24e56831464c47d62202f
Autor:
Adam Noble, Sarah Nevitt, Emily Holmes, Leone Ridsdale, Myfanwy Morgan, Catrin Tudur-Smith, Dyfrig Hughes, Steve Goodacre, Tony Marson, Darlene Snape
Publikováno v:
Health Services and Delivery Research, Vol 8, Iss 39 (2020)
Background: No seizure first aid training intervention exists for people with epilepsy who regularly attend emergency departments and their significant others, despite such an intervention’s potential to reduce clinically unnecessary and costly vis
Externí odkaz:
https://doaj.org/article/c87255e018164e33acad9fc8e2969935
Autor:
Nisaharan Srikandarajah, Adam Noble, Simon Clark, Martin Wilby, Brian J C Freeman, Michael G Fehlings, Paula R Williamson, Tony Marson
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0225907 (2020)
BACKGROUND:Cauda Equina Syndrome (CES) is an emergency condition that requires acute intervention and can lead to permanent neurological deficit in working age adults. A Core Outcome Set (COS) is the minimum set of outcomes that should be reported by
Externí odkaz:
https://doaj.org/article/a326ff62d8914232aa2a28bdea2daf21
Autor:
Sheenagh G. Aiken, Joseph M. Bateman, Hsuan-Hung Liao, Alexander Fawcett, Teerawut Bootwicha, Paolo Vincetti, Eddie L. Myers, Adam Noble, Varinder K. Aggarwal
Publikováno v:
Nature Chemistry. 15:248-256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dafcdae51969413d78c3cd493777a25
https://doi.org/10.1038/s41557-022-01087-9
https://doi.org/10.1038/s41557-022-01087-9
Autor:
Lucas I Iñigo Gamiz, Bernhard Ersfeld, Enrico Brunetti, Samuel R Yoffe, R Alan Cairns, Adam Noble, George K Holt, Dino A Jaroszynski
Publikováno v:
New Journal of Physics, Vol 23, Iss 4, p 043017 (2021)
A theoretical model is developed to describe the formation of microstructures due to plasma streaming instabilities in radially convergent geometries. Microstructures in the form of radial spokes are found experimentally in laser wakefield accelerato
Externí odkaz:
https://doaj.org/article/72f3e1e3a61d45fc9c4a297a46f3e8e9
Publikováno v:
New Journal of Physics, Vol 23, Iss 11, p 115007 (2021)
A charged particle subject to strong external forces will accelerate, and so radiate energy, inducing a self-force. This phenomenon remains contentious, but advances in laser technology mean we will soon encounter regimes where a more complete unders
Externí odkaz:
https://doaj.org/article/881eed064d914905b12a39929bbd404a
Publikováno v:
Angewandte Chemie International Edition. 62
The development of preparative methods for the synthesis of four-membered carbocycles is gaining increasing importance due to the widespread utility of cyclic compounds in medicinal chemistry. Herein, we report the development of a new methodology fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106ccaacee50d5291e52806348310409
https://doi.org/10.1002/anie.202217064
https://doi.org/10.1002/anie.202217064
Autor:
Joseph C. Abell, Christian P. Bold, Laia Vicens, Tom Jentsch, Noelia Velasco, Jasper L. Tyler, Robert N. Straker, Adam Noble, Varinder K. Aggarwal
Publikováno v:
Abell, J C, Bold, C P, Vicens, L, Jentsch, T, Velasco, N, Tyler, J L, Straker, R N, Noble, A & Aggarwal, V K 2023, ' Synthesis of Dihydropyridine Spirocycles by Semi-Pinacol-Driven Dearomatization of Pyridines ', Organic Letters, vol. 25, no. 2, pp. 400-404 . https://doi.org/10.1021/acs.orglett.2c04095
The identification of the beneficial pharmacokinetic properties of aza-spirocycles has led to the routine incorporation of these highly rigid and three-dimensional structures in pharmaceuticals. Herein, we report an operationally simple synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780ae5fd9fd9e3ca24fbe2991bf74e56
https://research-information.bris.ac.uk/ws/files/354045330/acs.orglett.2c04095.pdf
https://research-information.bris.ac.uk/ws/files/354045330/acs.orglett.2c04095.pdf
Publikováno v:
Sang, R, Noble, A & Aggarwal, V K 2021, ' Chiral Benzothiophene Synthesis via Enantiospecific Coupling of Benzothiophene S-Oxides with Boronic Esters ', Angewandte Chemie-International Edition, vol. 60, no. 48, pp. 25313-25317 . https://doi.org/10.1002/anie.202112180
Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Herein, we report a general method for the synthesis of enantioenriched 2,3-disubstituted benzothiophenes via a transition-metal-free C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36201f92fc3d5bab46d7680d2ae3c2e6
https://doi.org/10.1002/ange.202112180
https://doi.org/10.1002/ange.202112180
Autor:
Valerio Fasano, Andrew J. Orr-Ewing, Mahima Sneha, Ian P. Clark, Adam Noble, Varinder K. Aggarwal, Luke J Lewis-Borrell
Publikováno v:
Lewis-Borrell, L J, Sneha, M, Clark, I P, Fasano, V, Noble, A, Aggarwal, V K & Orr-Ewing, A J 2021, ' Direct Observation of Reactive Intermediates by Time-Resolved Spectroscopy Unravels the Mechanism of a Radical-Induced 1,2-Metalate Rearrangement ', Journal of the American Chemical Society, vol. 143, no. 41, pp. 17191-17199 . https://doi.org/10.1021/jacs.1c07964
Radical-induced 1,2-metallate rearrangements of boronate complexes are an emerging and promising class of reactions that allow multiple new bonds to be formed in a single, tuneable reaction step. These reactions involve the addition of an alkyl radic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f05a3a9f30e0b091c96e2e8338cc232
https://doi.org/10.1021/jacs.1c07964
https://doi.org/10.1021/jacs.1c07964