Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Adam, Krysztofiak"'
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The BRCA2 germline missense variant, R3052W, resides in the DNA binding domain and has been previously classified as a pathogenic allele. In this study, we sought to determine how R3052W alters the cellular functions of BRCA2 in the DNA damage respon
Externí odkaz:
https://doaj.org/article/dcd6e2d5d5b44aa6908028ee563d0219
Autor:
Adam Krysztofiak, Klaudia Szymonowicz, Julian Hlouschek, Kexu Xiang, Christoph Waterkamp, Safa Larafa, Isabell Goetting, Silvia Vega-Rubin-de-Celis, Carsten Theiss, Veronika Matschke, Daniel Hoffmann, Verena Jendrossek, Johann Matschke
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103366- (2021)
Summary: Cancer bioenergetics fuel processes necessary to maintain viability and growth under stress conditions. We hypothesized that cancer metabolism supports the repair of radiation-induced DNA double-stranded breaks (DSBs). We combined the system
Externí odkaz:
https://doaj.org/article/f4f90a877f724fafa3cbfea6ae94db1b
Autor:
Peter M. Glazer, Faye A. Rogers, Daniel A. Colon-Rios, Yanfeng Liu, Adam Krysztofiak, Jonathan Dow
SFig 1: SAHA reduces H3K9 trimethylation in IDH1 mutant cells while increasing H3K9 and H4 acetylation, SFig 2: Characterization of U2OS EJDR cells after SAHA, metabolite and siRNA treatment, SFig 3: SAHA elevates DNA damage to a greater degree in ID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd453ad8f5ff879de20c6b02edaa6d5f
https://doi.org/10.1158/1541-7786.22527809.v1
https://doi.org/10.1158/1541-7786.22527809.v1
Autor:
Klaudia Szymonowicz, Adam Krysztofiak, Jansje van der Linden, Ajvar Kern, Simon Deycmar, Sebastian Oeck, Anthony Squire, Benjamin Koska, Julian Hlouschek, Melanie Vüllings, Christian Neander, Jens T. Siveke, Johann Matschke, Martin Pruschy, Beate Timmermann, Verena Jendrossek
Publikováno v:
Cells, Vol 9, Iss 4, p 889 (2020)
Technical improvements in clinical radiotherapy for maximizing cytotoxicity to the tumor while limiting negative impact on co-irradiated healthy tissues include the increasing use of particle therapy (e.g., proton therapy) worldwide. Yet potential di
Externí odkaz:
https://doaj.org/article/af29afe2eb6a475593fd2b949fb00dd8
Autor:
Yanfeng Liu, Adam Krysztofiak, Cynthia Chan, Meetu Kaushik Tiwari, W. Mark Saltzman, Daniel A. Colon-Rios, Eric Song, Elias Quijano, Hee-Won Suh, Hemanta C. Rao Tumu, Demetrios T. Braddock, Faye A. Rogers
Publikováno v:
Nature Biotechnology. 40:325-334
Gene amplification drives oncogenesis in a broad spectrum of cancers. A number of drugs have been developed to inhibit the protein products of amplified driver genes, but their clinical efficacy is often hampered by drug resistance. Here, we introduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16eab5a1ec655a01c887a2d05d983e34
https://doi.org/10.1038/s41587-021-01057-5
https://doi.org/10.1038/s41587-021-01057-5
Autor:
Jonathan Dow, Daniel A. Colon-Rios, Adam Krysztofiak, Faye A. Rogers, Peter M. Glazer, Yanfeng Liu
Publikováno v:
Mol Cancer Res
Exploitation of DNA repair defects has enabled major advances in treating specific cancers. Recent work discovered that the oncometabolite 2-hydroxyglutarate (2-HG), produced by neomorphic isocitrate dehydrogenase 1/2 (IDH1/2) mutations, confers a ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c483d763c6fba50e4d28f8adacd7d37
https://europepmc.org/articles/PMC8642278/
https://europepmc.org/articles/PMC8642278/
Publikováno v:
Journal of Medical Science, Vol 83, Iss 3 (2014)
UDP-glucuronosyltransferases (UGTs) are important detoxification and drug-metabolizing enzymes, which catalyse the glucuronidation of exogenous and endogenous chemicals. The anti-carcinogenic activity of dietary phytochemicals is partly attributed to
Externí odkaz:
https://doaj.org/article/9c878b110e294a1c9c5a209c39988667
Autor:
Carsten Theiss, Johann Matschke, Christoph Waterkamp, Veronika Matschke, Klaudia Szymonowicz, Julian Hlouschek, Silvia Vega-Rubin-de-Celis, Isabell Goetting, Safa Larafa, Daniel Hoffmann, Verena Jendrossek, Kexu Xiang, Adam Krysztofiak
Publikováno v:
iScience
iScience, Vol 24, Iss 11, Pp 103366-(2021)
iScience, Vol 24, Iss 11, Pp 103366-(2021)
Summary Cancer bioenergetics fuel processes necessary to maintain viability and growth under stress conditions. We hypothesized that cancer metabolism supports the repair of radiation-induced DNA double-stranded breaks (DSBs). We combined the systema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4e97be442a548767b1239f037d157d
https://doi.org/10.1016/j.isci.2021.103366
https://doi.org/10.1016/j.isci.2021.103366
Autor:
Verena Jendrossek, Klaudia Szymonowicz, Julian Hlouschek, Christoph Waterkamp, Johann Matschke, Kexu Xiang, Adam Krysztofiak, Daniel Hoffmann
Publikováno v:
Cancer Research. 81:3065-3065
Flexibility and reprogramming of cancer metabolism supports cancer progression and therapy resistance. In previous work we described opportunities for overcoming environment-induced resistance to ionizing radiation (IR) by pharmacologic inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::005400c9d5c0cfaf31676bcca1100741
https://doi.org/10.1158/1538-7445.am2021-3065
https://doi.org/10.1158/1538-7445.am2021-3065
Autor:
Adam Krysztofiak, Audrey Turchick, Sebastian Oeck, Nathalie M. Malewicz, Verena Jendrossek, Peter M. Glazer
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports
Scientific Reports
DNA- and histone-related research frequently comprises the quantitative analysis of protein modifications, such as histone phosphorylation. Analysis of accumulation and disappearance of protein foci are used to monitor DNA damage and repair kinetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd378c257be24a3b6b2fae69bfc727d6
https://doi.org/10.1038/s41598-019-39760-8
https://doi.org/10.1038/s41598-019-39760-8