Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Adam, Hendricson"'
Autor:
Sateja Paradkar, Adam Hendricson, Mark Plummer, Ranjini K. Sundaram, James Herrington, Denton Hoyer, Ranjit S. Bindra, Yulia V. Surovtseva, Piyasena Hewawasam
Publikováno v:
Oncotarget
Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system with a dismal prognosis. Locoregional failure is common despite high doses of radiation therapy, which has prompted great interest in developing novel strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b96f25b0746c867fcdee576b3c9434
https://doi.org/10.18632/oncotarget.27933
https://doi.org/10.18632/oncotarget.27933
Autor:
Linda J Bristow, Amy E Easton, Yu-Wen Li, Digavalli V Sivarao, Regina Lidge, Kelli M Jones, Debra Post-Munson, Christopher Daly, Nicholas J Lodge, Lizbeth Gallagher, Thaddeus Molski, Richard Pieschl, Ping Chen, Adam Hendricson, Ryan Westphal, James Cook, Christiana Iwuagwu, Daniel Morgan, Yulia Benitex, Dalton King, John E Macor, Robert Zaczek, Richard Olson
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159996 (2016)
The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia patients. In the present studies we characterized the novel agent, (2R)-N-(6-(1H-imidazol-
Externí odkaz:
https://doaj.org/article/cb2d80cbb97446c297511d2d30823d16
Autor:
Valerie J. Whiterock, Amy Easton, Regina Miller, Lawrence R. Marcin, Meredith Ferrante, Bradley C. Pearce, John B. Hogan, Joanne J. Bronson, Clotilde Bourin, Mendi A. Higgins, Robert G. Gentles, F. Christopher Zusi, Walter Kostich, John E. Macor, Michael Gulianello, Min Ding, Linda J. Bristow, Adam Hendricson, Kim A. Johnson, Andrew Alt, Yanling Huang, Matthew A. Seager
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:496-513
Triazolopyridine ethers with mGlu2 positive allosteric modulator (PAM) activity are disclosed. The synthesis, in vitro activity, and metabolic stability data for a series of analogs is provided. The effort resulted in the discovery of a potent, selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4fbbfea4e7fe10fc6e8c858a57219bd
https://doi.org/10.1016/j.bmc.2016.11.018
https://doi.org/10.1016/j.bmc.2016.11.018
Autor:
Mendi A, Higgins, Lawrence R, Marcin, F, Christopher Zusi, Robert, Gentles, Min, Ding, Bradley C, Pearce, Amy, Easton, Walter A, Kostich, Matthew A, Seager, Clotilde, Bourin, Linda J, Bristow, Kim A, Johnson, Regina, Miller, John, Hogan, Valerie, Whiterock, Michael, Gulianello, Meredith, Ferrante, Yanling, Huang, Adam, Hendricson, Andrew, Alt, John E, Macor, Joanne J, Bronson
Publikováno v:
Bioorganicmedicinal chemistry. 25(2)
Triazolopyridine ethers with mGlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c51d8b2216df7c3ae7ce8e46554f0338
https://pubmed.ncbi.nlm.nih.gov/27914948
https://pubmed.ncbi.nlm.nih.gov/27914948
Autor:
Ronald J. Knox, Linda J. Bristow, Rick L. Pieschl, Ivar M. McDonald, Michael R. Weed, Thaddeus F. Molski, Michael K. Ahlijanian, James Herrington, Laszlo Kiss, Debra J. Post-Munson, Adam Hendricson, John E. Macor, Richard E. Olson, John D. Graef
Publikováno v:
European journal of pharmacology. 799
The alpha7 (α7) nicotinic acetylcholine receptor is a therapeutic target for cognitive disorders. Here we describe 3-(3,4-difluorophenyl)-N-(1-(6-(4-(pyridin-2-yl)piperazin-1-yl)pyrazin-2-yl)ethyl)propanamide (B-973), a novel piperazine-containing m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4888e75829926727f8f39bfc406522ba
https://pubmed.ncbi.nlm.nih.gov/28132910
https://pubmed.ncbi.nlm.nih.gov/28132910
Autor:
Debra J. Post-Munson, Ping Chen, Linda J. Bristow, Daniel G. Morgan, Ryan Westphal, Kelli M. Jones, Adam Hendricson, Lizbeth Gallagher, Dalton King, Yulia Benitex, Richard Pieschl, Digavalli V. Sivarao, Christiana I. Iwuagwu, Robert Zaczek, Regina Lidge, Nicholas J. Lodge, John E. Macor, Amy Easton, James H. Cook, Yu-Wen Li, Thaddeus F. Molski, Richard E. Olson, Christopher Daly
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 7, p e0159996 (2016)
PLoS ONE, Vol 11, Iss 7, p e0159996 (2016)
The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia patients. In the present studies we characterized the novel agent, (2R)-N-(6-(1H-imidazol-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e845cf9f7d9cd9aa45b681f10cc5d9bb
http://europepmc.org/articles/PMC4965148
http://europepmc.org/articles/PMC4965148
Autor:
Diana Janke, Haiheng Dong, David Parker, Hassan Pajouhesh, Francesco Belardetti, Afsheen Khawaja, Stephen P. Arneric, Terrance P. Snutch, Cyrus Eduljee, Robert A. Fraser, Adam Hendricson, Elizabeth Tringham, Yoko Shimizu, Xinpo Jiang, Janette Mezeyova
Publikováno v:
ASSAY and Drug Development Technologies. 7:266-280
T-type voltage-gated Ca(2+) channels have been implicated in contributing to a broad variety of human disorders, including pain, epilepsy, sleep disturbances, cardiac arrhythmias, and certain types of cancer. However, potent and selective T-type Ca(2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162c63cc63952e5474aabff069f3eded
https://doi.org/10.1089/adt.2009.191
https://doi.org/10.1089/adt.2009.191
Autor:
John J. Herbst, Meredith Ferrante, Annapurna Pendri, Kristin L. Rockwell, Jonathan O’Connell, Susan Jenkins, James Loy, Chi Shing Sum, Adam Hendricson, Martyn Banks, Robert G. Gentles, Yulia Benitex, Robert L. Bertekap, Neil T. Burford, Mary Ellen Cvijic, John E. Macor, Andrew Alt, Litao Zhang, Ryan Westphal, Jing Chen, Michelle Nophsker, Guo Li
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 356(2)
The muscarinic acetylcholine receptor subtype 1 (M1) receptors play an important role in cognition and memory, and are considered to be attractive targets for the development of novel medications to treat cognitive impairments seen in schizophrenia a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd8ea774d222131b249c03f262e27f3
https://pubmed.ncbi.nlm.nih.gov/26582730
https://pubmed.ncbi.nlm.nih.gov/26582730
Autor:
Michael R. Weed, Jeffrey M. Brown, Brett R. Beno, Ryan S. Westphal, Robert G. Gentles, John Watson, Yan Kong, Lisa Hunihan, Martin A. Lewis, Mary Ellen Cvijic, John E. Macor, Joanne J. Bronson, Meredith Ferrante, Thaddeus F. Molski, Ronald J. Knox, Andrew Alt, Angela Cacace, Kristin L. Rockwell, Shuanghua Hu, Adam Hendricson, Yazhong Huang
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 354(3)
The present studies represent the first published report of a dopamine D1 positive allosteric modulator (PAM). D1 receptors have been proposed as a therapeutic target for the treatment of cognitive deficits associated with schizophrenia. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d604e231071ac7177ea3adadb9588803
https://pubmed.ncbi.nlm.nih.gov/26109678
https://pubmed.ncbi.nlm.nih.gov/26109678
Autor:
Joanne J. Bronson, Adam Hendricson, Ryan Westphal, John E. Macor, Lisa Hunihan, Margaret M. Prack, Jeffrey M. Brown, David G. Harden, Robert G. Gentles, Rudy Krause, Carolyn Diane Dzierba
Publikováno v:
Journal of neurochemistry. 129(2)
NMDA receptor hypofunction is hypothesized to contribute to cognitive deficits associated with schizophrenia. Since direct activation of NMDA receptors is associated with serious adverse effects, modulation of the NMDA co-agonists, glycine or D-serin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc37d3dc783057cadcf89f9b25fea647
https://pubmed.ncbi.nlm.nih.gov/24266811
https://pubmed.ncbi.nlm.nih.gov/24266811