Zobrazeno 1 - 10
of 801
pro vyhledávání: '"Adalberto, Pessoa"'
Autor:
Nicolás Lefin, Javiera Miranda, Jorge F. Beltrán, Lisandra Herrera Belén, Brian Effer, Adalberto Pessoa, Jorge G. Farias, Mauricio Zamorano
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Heterologous expression of L-asparaginase (L-ASNase) has become an important area of research due to its clinical and food industry applications. This review provides a comprehensive overview of the molecular and metabolic strategies that can be used
Externí odkaz:
https://doaj.org/article/bbc9b3a9fbac46e0ba0fc5b208e388f2
Autor:
Samuel Leite Cardoso, Paula Monteiro Souza, Kelly Rodrigues, Isabella de Souza Mota, Edivaldo Ferreira Filho, Léia Cecilia de Lima Fávaro, Felipe Saldanha-Araujo, Mauricio Homem-de-Mello, Adalberto Pessoa, Dâmaris Silveira, Yris Maria Fonseca-Bazzo, Pérola Oliveira Magalhães
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2352 (2023)
The search for new drug-producing microorganisms is one of the most promising situations in current world scientific scenarios. The use of molecular biology as well as the cloning of protein and compound genes is already well established as the gold
Externí odkaz:
https://doaj.org/article/11c0314a4af347e5b061f597e215465a
Autor:
Kellen C. R. Andrade, Rildo A. Fernandes, Danilo Batista Pinho, Marcela M. de Freitas, Edivaldo Ximenes Ferreira Filho, Adalberto Pessoa, João Inácio Silva, Perola O. Magalhães
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The enzyme L-asparaginase (L-ASNase) is used in the treatment of Acute Lymphoblastic Leukemia. The preparations of this enzyme for clinical use are derived from bacterial sources and its use is associated with serious adverse reactions. In t
Externí odkaz:
https://doaj.org/article/0ddc797cf0064351ac855f8c8ee61da4
Autor:
Louise Lacalendola Tundisi, Diego de Freitas Coêlho, Alessandra Valéria de Sousa Faria, Adalberto Pessoa Junior, Elias Basile Tambourgi, Laura de Oliveira Nascimento, Edgar Silveira, Priscila Gava Mazzola
Publikováno v:
Brazilian Journal of Pharmaceutical Sciences, Vol 58 (2022)
Abstract L-Asparaginase (L-ASNase) is a biopharmaceutical used for acute lymphoblastic leukaemia (ALL) treatment, dramatically increasing the patients’ chance of cure. However, its production and distribution in developing countries were disrupted
Externí odkaz:
https://doaj.org/article/102ccfa4a5024dcd80c6e5ae31d7466a
Publikováno v:
Bioengineering, Vol 10, Iss 4, p 431 (2023)
Aeromonas caviae CHZ306, a marine-derived bacterium isolated from zooplankton, can use chitin (a polymer of a β-(1,4)-linked N-acetyl-D-glucosamine) as a carbon source. The chitin is hydrolyzed by chitinolytic enzymes, namely endochitinases and exoc
Externí odkaz:
https://doaj.org/article/ff22e6f185da4a68ae7e5a054d469a07
Autor:
Rafaely Angelica Fonseca Bandeira, Almir Mariano de Sousa Junior, Francisco Adalberto Pessoa de Carvalho Segundo, Eriberto Carlos Mendes da Silva, Monallisa Cristina Holanda
Publikováno v:
Vetor, Vol 28, Iss 1-2 (2021)
Na década de 1970, a indústria da construção civil no Brasil apresentou o maior número de acidentes de todo o mundo. Diante deste quadro, com o intuito de minimizar e prevenir acidentes laborais, foi criada em âmbito nacional, a legislação de
Externí odkaz:
https://doaj.org/article/36827eb28911455fa765f087e0c3b91c
Autor:
Suellen Machado, Valker Feitosa, Omar Pillaca-Pullo, Luciana Lario, Lara Sette, Adalberto Pessoa, Harley Alves
Publikováno v:
Bioengineering, Vol 9, Iss 11, p 694 (2022)
Microbial proteases, especially aspartic proteases, are an essential group of enzymes produced from different microorganisms. Microbial proteases have several applications, mainly in the food, beverage, cosmetic, and pharmaceutical industries, due to
Externí odkaz:
https://doaj.org/article/4418d540371240bd947b7fc6800d9e29
Autor:
Mauricio Zamorano, Rodrigo L. Castillo, Jorge F. Beltran, Lisandra Herrera, Joaquín A. Farias, Christian Antileo, Cristobal Aguilar-Gallardo, Adalberto Pessoa, Yolanda Calle, Jorge G. Farias
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Ischemia is a severe condition in which blood supply, including oxygen (O), to organs and tissues is interrupted and reduced. This is usually due to a clog or blockage in the arteries that feed the affected organ. Reinstatement of blood flow is essen
Externí odkaz:
https://doaj.org/article/e3e44ca76bc5413f88dd6359dcd6f9aa
Autor:
Marina de Souza Guimarães, Jorge Javier Muso Cachumba, Cecilia Zorzi Bueno, Karin Mariana Torres-Obreque, Grace Verónica Ruiz Lara, Gisele Monteiro, Leandro Ramos Souza Barbosa, Adalberto Pessoa, Carlota de Oliveira Rangel-Yagui
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1819 (2022)
L-asparaginase (ASNase) is an important biological drug used to treat Acute Lymphoblastic Leukemia (ALL). It catalyzes the hydrolysis of L-asparagine (Asn) in the bloodstream and, since ALL cells cannot synthesize Asn, protein synthesis is impaired l
Externí odkaz:
https://doaj.org/article/4aeba7156d334adab42ce80974386a8b
Autor:
Ignacio S. Moguel, Celina K. Yamakawa, Larissa P. Brumano, Adalberto Pessoa, Solange I. Mussatto
Publikováno v:
Fermentation, Vol 8, Iss 8, p 398 (2022)
This study reports the production of L-asparaginase (ASNase), an enzyme mainly used for the treatment of acute lymphoblastic leukemia, by Leucosporidiumscottii L115, a psychrotolerant yeast isolated from the Antarctic ecosystem. Focus was given to se
Externí odkaz:
https://doaj.org/article/176c7f024f104ae3a1153ec7a0c82dc1