Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Adaikalavan, Ramasamy"'
Autor:
Sean W. D. Carter, Erin L. Fee, Haruo Usuda, Gokce Oguz, Adaikalavan Ramasamy, Zubair Amin, Biswas Agnihotri, Qin Wei, Liu Xiawen, Tsukasa Takahashi, Yuki Takahashi, Hideyuki Ikeda, Yusaku Kumagai, Yuya Saito, Masatoshi Saito, Citra Mattar, Mark I. Evans, Sebastián E. Illanes, Alan H. Jobe, Mahesh Choolani, Matthew W. Kemp
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Antenatal steroid therapy for fetal lung maturation is routinely administered to women at risk of preterm delivery. There is strong evidence to demonstrate benefit from antenatal steroids in terms of survival and respiratory disea
Externí odkaz:
https://doaj.org/article/18c4c9d17a3f44d69b47504a4d6fb10e
Autor:
Arjunan Subramanian, Chelsea Han Lin IP, Wei Qin, Xiawen Liu, Sean W.D. Carter, Gokce Oguz, Adaikalavan Ramasamy, Sebastian E. Illanes, Arijit Biswas, Gabriel G. Perron, Erin L. Fee, Sarah W. L. Li, Michelle K.Y. Seah, Mahesh A. Choolani, Matthew W. Kemp
Publikováno v:
npj Microgravity, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Human Wharton’s jelly stem cells (hWJSCs) are multipotent stem cells that are extensively employed in biotechnology applications. However, the impact of simulated lunar microgravity (sμG) on the growth, differentiation, and viability of t
Externí odkaz:
https://doaj.org/article/28651a06a16f45f399d07cd702b01869
Autor:
Sean W. D. Carter, Erin L. Fee, Haruo Usuda, Gokce Oguz, Adaikalavan Ramasamy, Zubair Amin, Biswas Agnihotri, Qin Wei, Liu Xiawen, Tsukasa Takahashi, Yuki Takahashi, Hideyuki Ikeda, Yusaku Kumagai, Yuya Saito, Masatoshi Saito, Citra Mattar, Mark I. Evans, Sebastián E. Illanes, Alan H. Jobe, Mahesh Choolani, Matthew W. Kemp
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e2312d40ed90471f858155cbcccfd7be
Autor:
Tram Anh Nguyen, Jia Wei Joel Heng, Yan Ting Ng, Rui Sun, Shira Fisher, Gokce Oguz, Pornchai Kaewsapsak, Shifeng Xue, Bruno Reversade, Adaikalavan Ramasamy, Eli Eisenberg, Meng How Tan
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-25 (2023)
Abstract Background Xenopus has served as a valuable model system for biomedical research over the past decades. Notably, ADAR was first detected in frog oocytes and embryos as an activity that unwinds RNA duplexes. However, the scope of A-to-I RNA e
Externí odkaz:
https://doaj.org/article/abccd887de8d46a085dc1ca76e7b252c
Autor:
Meyammai Shanmugham, Arun George Devasia, Yu Ling Chin, Kang Hao Cheong, Eng Shi Ong, Sophie Bellanger, Adaikalavan Ramasamy, Chen Huei Leo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Endothelial dysfunction is a critical initiating factor contributing to cardiovascular diseases, involving the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO). This study aims to clarify the time-dependent molecular pathways
Externí odkaz:
https://doaj.org/article/4d802a0a686c46d3bf8a857941c3c1b6
Autor:
Ah-Jung Jeon, Yue-Yang Teo, Karthik Sekar, Shay Lee Chong, Lingyan Wu, Sin-Chi Chew, Jianbin Chen, Raden Indah Kendarsari, Hannah Lai, Wen Huan Ling, Neslihan Arife Kaya, Jia Qi Lim, Adaikalavan Ramasamy, Gokce Oguz, Alexander Yaw-Fui Chung, Chung Yip Chan, Peng-Chung Cheow, Juinn Huar Kam, Krishnakumar Madhavan, Alfred Kow, Iyer Shridhar Ganpathi, Tony Kiat Hon Lim, Wei-Qiang Leow, Shihleone Loong, Tracy Jiezhen Loh, Wei Keat Wan, Gwyneth Shook Ting Soon, Yin Huei Pang, Boon Koon Yoong, Diana Bee-Lan Ong, Jasmine Lim, Vanessa H. de Villa, Rouchelle D.dela Cruz, Rawisak Chanwat, Jidapa Thammasiri, Glenn K. Bonney, Brian K. P. Goh, Greg Tucker-Kellogg, Roger Sik Yin Foo, Pierce K. H. Chow
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Background Conventional differential expression (DE) testing compares the grouped mean value of tumour samples to the grouped mean value of the normal samples, and may miss out dysregulated genes in small subgroup of patients. This is especi
Externí odkaz:
https://doaj.org/article/ac89eae58a5449229b3b4f7dcae89062
Autor:
Sartaj Ahmad Mir, Li Chen, Satvika Burugupalli, Bo Burla, Shanshan Ji, Adam Alexander T. Smith, Kothandaraman Narasimhan, Adaikalavan Ramasamy, Karen Mei-Ling Tan, Kevin Huynh, Corey Giles, Ding Mei, Gerard Wong, Fabian Yap, Kok Hian Tan, Fiona Collier, Richard Saffery, Peter Vuillermin, Anne K. Bendt, David Burgner, Anne-Louise Ponsonby, Yung Seng Lee, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Peter J. Meikle, Markus R. Wenk, Neerja Karnani
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Lipids play a vital role in health and disease, but changes to their circulating levels and the link with obesity remain poorly characterized in expecting mothers and their offspring in early childhood. Methods LC-MS/MS-based quan
Externí odkaz:
https://doaj.org/article/2a524f4cbd2448029ad0b8261c9144bb
Autor:
Shijun Ma, Yue Zhao, Wee Chyan Lee, Li-Teng Ong, Puay Leng Lee, Zemin Jiang, Gokce Oguz, Zhitong Niu, Min Liu, Jian Yuan Goh, Wenyu Wang, Matias A. Bustos, Sidse Ehmsen, Adaikalavan Ramasamy, Dave S. B. Hoon, Henrik J. Ditzel, Ern Yu Tan, Qingfeng Chen, Qiang Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Hypoxia can promote tumor escape from immune surveillance and immunotherapy. Here, the authors show that hypoxia induces T and NK cell dysfunction through HIF1α-mediated epigenetic suppression of effector gene expression, conferring resistance to an
Externí odkaz:
https://doaj.org/article/f4d636bacf6c468fb0de459e001bd7f5
Autor:
Sebastian Guelfi, Karishma D’Sa, Juan A. Botía, Jana Vandrovcova, Regina H. Reynolds, David Zhang, Daniah Trabzuni, Leonardo Collado-Torres, Andrew Thomason, Pedro Quijada Leyton, Sarah A. Gagliano Taliun, Mike A. Nalls, International Parkinson’s Disease Genomics Consortium (IPDGC), UK Brain Expression Consortium (UKBEC), Kerrin S. Small, Colin Smith, Adaikalavan Ramasamy, John Hardy, Michael E. Weale, Mina Ryten
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Regulation of gene expression and splicing are thought to be tissue-specific. Here, the authors obtain genomic and transcriptomic data from putamen and substantia nigra of 117 neurologically healthy human brains and find that splicing eQTLs are enric
Externí odkaz:
https://doaj.org/article/d83bf92ed8ef48c8b17db5f5eae7d0d7
Autor:
Aparna Sampathkumar, Karen M. Tan, Li Chen, Mary F. F. Chong, Fabian Yap, Keith M. Godfrey, Yap Seng Chong, Peter D. Gluckman, Adaikalavan Ramasamy, Neerja Karnani
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Vitamin D is an essential micronutrient whose demand is heightened during pregnancy to support the growth of the fetus. Furthermore, the fetus does not produce vitamin D and hence relies exclusively on the supply of maternal vitamin D through the pla
Externí odkaz:
https://doaj.org/article/900ead58e96d45a99d3b1f663cdbce7d