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Akademický článek

Pattern, challenges and correlates of condom use among Nigerians living with HIV infection.

Autor: Oladele David Ayoola, Gab-Okafor Chidinma Victoria, Oke Bamidele, Kalejaiye Olufunto Olufela, Somefun Esther Oluwatosin, Ezeobi Paschal Mbaneifo, Gbajabiamila Titilola, Adu Rosemary Adagu, Onwujekwe Dan Ifeanyi, Ohwodo Harry, Odubela Oluwatosin, Odunukwe Nkiru Nonyelum, David Nkiruka, Ezechi Oliver Chukwujekwu

Publikováno v: Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S1, Pp S198-S203 (2014)

Objective: To determine the pattern, challenges and correlates of condom use among Nigerians living with HIV Infection. Methods: A cross sectional questionnaire study among HIV positive adults attending an HIV treatment centre in Lagos, Nigeria. Data

Externí odkaz: https://doaj.org/article/f2a27d5d15764973acc0ec1d602c4559

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Akademický článek

Detecção da mutação dupla 86TYR e 1246TYR no gene pfmdr1 em clones de uma amostra de Plasmodium falciparum da África Ocidental, resistente à cloroquina.

Autor: L Pinheiro, S Franco, I S Adagu, R Rosa, V E Rosário, D C Warhurst

Publikováno v: Acta Médica Portuguesa, Vol 16, Iss 4 (2003)

Isolates of Plasmodium falciparum from three areas of West Africa were recovered from cryopreservation and their chloroquine-sensitivity were determined in vitro. Of the 90 samples studied, 60 were from Guinea-Bissau (30Resistant/30Sensitive), 15 wer

Externí odkaz: https://doaj.org/article/ba47d0367bd140afb7252bed5afa32fb

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Akademický článek

SIMPLIFIED DIAGNOSIS OF MALARIA INFECTION: GFM/PCR/ELISA A SIMPLIFIED NUCLEIC ACID AMPLIFICATION TECHNIQUE BY PCR/ELISA

Autor: Ricardo Luiz Dantas MACHADO, Denise Oliveira GARRET, Ipemida Sullayman ADAGU, David Charles WARHURST, Marinete Marins PÓVOA

Publikováno v: Revista do Instituto de Medicina Tropical de São Paulo, Vol 40, Iss 5 (1998)

We report an adaptation of a technique for the blood sample collection (GFM) as well as for the extraction and amplification of Plasmodium DNA for the diagnosis of malaria infection by the PCR/ELISA. The method of blood sample collection requires les

Externí odkaz: https://doaj.org/article/1260e4aaba7a4a899768ac277658f0c9

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Akademický článek

The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids

Autor: Meyer David J, Adagu Ipemida S, Craig John C, Warhurst David C, Lee Sylvia Y

Publikováno v: Malaria Journal, Vol 2, Iss 1, p 26 (2003)

Abstract Background The 8-amino and 9-hydroxy substituents of antimalarial cinchona alkaloids have the erythro orientation while their inactive 9-epimers are threo. From the X-ray structures a 90° difference in torsion angle between the N1-H1 and C9

Externí odkaz: https://doaj.org/article/68aabdda05f9471a83371ff39d1284d5

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Akademický článek

Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

Autor: Warhurst David C, Adagu Ipemida S, Butcher Geoffrey A, Fivelman Quinton L, Pasvol Geoffrey

Publikováno v: Malaria Journal, Vol 1, Iss 1, p 1 (2002)

Abstract We report the first in vitro and genetic confirmation of Malarone® (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a

Externí odkaz: https://doaj.org/article/9032c516f1a240ebacced2ef86cd7fdc

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Akademický článek

Plasmodium falciparum in Kenya: high prevalence of drug-resistance-associated polymorphisms in hospital admissions with severe malaria in an epidemic area.

Autor: Omar, S. A.¹, Adagu, I. S.², Gump, D. W.³, Ndaru, N. P.⁴, Warhurst, D. C.²

Publikováno v: Annals of Tropical Medicine & Parasitology. Oct2001, Vol. 95 Issue 7, p661-669. 9p. 1 Chart.

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Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum

Autor: David C. Warhurst, Quinton L. Fivelman, I.S. Adagu, R. Kiplin Guy, John C. Craig, Peter B. Madrid

Publikováno v: Biochemical Pharmacology. 73:1910-1926

Chloroquine (CQ), a 4-aminoquinoline, accumulates in acidic digestive vacuoles of the malaria parasite, preventing conversion of toxic haematin to beta-haematin. We examine how bis 4-aminoquinoline piperaquine (PQ) and its hydroxy-modification (OH-PQ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c876b668e9afde6a406cbd5837cd39c5
https://doi.org/10.1016/j.bcp.2007.03.011

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Identification of Isoflavone Derivatives as Effective Anticryptosporidial Agents in Vitro and in Vivo

Autor: Neil G. Berry, Shelley L. Moores, Eleanor C. Row, Andrew V. Stachulski, I.S. Adagu, A. C. Lilian Low, David C. Warhurst, Jean-Francois Rossignol

Publikováno v: Journal of Medicinal Chemistry. 49:1450-1454

We report the preparation and antiparasitic activity in vitro and in vivo of a series of isoflavone derivatives related to genistein. These analogues retain the 5,7-dihydroxyisoflavone core of genistein: direct genistein analogues (2-H isoflavones),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d4185b9d6e9306d8b2a8121bae1d00
https://doi.org/10.1021/jm050973f

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Akademický článek

Field chloroquine resistance determinants.

Autor: Adagu, I.S.¹, Ogala, W.N.², Carucci, D.J.¹, Duraisingh, M.T.¹, Warhurst, D.C.¹

Publikováno v: Annals of Tropical Medicine & Parasitology. 1997 Supplement, Vol. 91, p107. 6p.

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