Výsledky vyhledávání - "Adagu, Ipemida S"

Akademický článek

The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids

Autor: Meyer David J, Adagu Ipemida S, Craig John C, Warhurst David C, Lee Sylvia Y

Publikováno v: Malaria Journal, Vol 2, Iss 1, p 26 (2003)

Abstract Background The 8-amino and 9-hydroxy substituents of antimalarial cinchona alkaloids have the erythro orientation while their inactive 9-epimers are threo. From the X-ray structures a 90° difference in torsion angle between the N1-H1 and C9

Externí odkaz: https://doaj.org/article/68aabdda05f9471a83371ff39d1284d5

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Akademický článek

Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

Autor: Warhurst David C, Adagu Ipemida S, Butcher Geoffrey A, Fivelman Quinton L, Pasvol Geoffrey

Publikováno v: Malaria Journal, Vol 1, Iss 1, p 1 (2002)

Abstract We report the first in vitro and genetic confirmation of Malarone® (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a

Externí odkaz: https://doaj.org/article/9032c516f1a240ebacced2ef86cd7fdc

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Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases

Autor: Warhurst, David C, Craig, John C, Adagu, Ipemida S, Guy, R Kiplin, Madrid, Peter B, Fivelman, Quinton L

Chloroquine (CQ), a 4-aminoquinoline, accumulates in acidic digestive vacuoles of the malaria parasite, preventing conversion of toxic haematin to beta-haematin. We examine how bis 4-aminoquinoline piperaquine (PQ) and its hydroxy-modification (OH-PQ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::857cc0f153f0e1f956e0e00ac14dc025
https://researchonline.lshtm.ac.uk/id/eprint/10051/1/Warhurst_etal_2007_Activity_of_piperaquine_and-other.pdf