LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy

Autor: Mónica Pascual-García, Ester Bonfill-Teixidor, Ester Planas-Rigol, Carlota Rubio-Perez, Raffaella Iurlaro, Alexandra Arias, Isabel Cuartas, Ada Sala-Hojman, Laura Escudero, Francisco Martínez-Ricarte, Isabel Huber-Ruano, Paolo Nuciforo, Leire Pedrosa, Carolina Marques, Irene Braña, Elena Garralda, María Vieito, Massimo Squatrito, Estela Pineda, Francesc Graus, Carmen Espejo, Juan Sahuquillo, Josep Tabernero, Joan Seoane

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

LIF is a pleiotropic cytokine that promotes an immunosuppressive microenvironment and has critical functions in embryonic development. Here, the authors show that LIF regulates CD8+ T cell tumor infiltration in cancer by repressing CXCL19 and promoti

Externí odkaz: https://doaj.org/article/eafd754e38d148f4af2177cb43fd4fa5

Supplementary Figure 1 from Active CREB1 Promotes a Malignant TGFβ2 Autocrine Loop in Glioblastoma

Autor: Joan Seoane, Elena Martínez-Sáez, Ada Sala-Hojman, María del Mar Inda, Alba Gonzàlez-Juncà, Laura Rodón

A graph showing the correlation of p-SMAD2 and p-CREB in GBM patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381d30001ab63eab8d49fd87ac6bd65c
https://doi.org/10.1158/2159-8290.22530698

LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy

Autor: Carolina Marques, Juan Sahuquillo, Elena Garralda, Ester Bonfill-Teixidor, Isabel Cuartas, Josep Tabernero, Estela Pineda, Irene Brana, Maria Vieito, Francisco Martínez-Ricarte, Francesc Graus, Laura Escudero, Carlota Rubio-Perez, Mónica Pascual-García, Raffaella Iurlaro, Massimo Squatrito, Joan Seoane, Ester Planas-Rigol, Alexandra Arias, Paolo Nuciforo, Ada Sala-Hojman, Carmen Espejo, Leire Pedrosa, Isabel Huber-Ruano

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Scientia
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)

Cancer response to immunotherapy depends on the infiltration of CD8+ T cells and the presence of tumor-associated macrophages within tumors. Still, little is known about the determinants of these factors. We show that LIF assumes a crucial role in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3562526c931f1c9279325cea163e8e9b
https://hdl.handle.net/20.500.12105/8322

Abstract LB-B34: LIF as a novel cancer immunotherapy target: modulating the tumor microenvironment with MSC-1, a humanized anti-LIF monoclonal antibody

Autor: Angus M. Sinclair, Jeanne Magram, Ada Sala, Kimberly Hoffman, Robert Wasserman, Robin M. Hallett, Judit Anido, Joan Seoane, Naimish Pandya, Monica Pascual, Vanessa Chiganças, Isabel Huber Ruano, Patricia Giblin

Publikováno v: Molecular Cancer Therapeutics. 17:LB-B34

Leukemia Inhibitory Factor (LIF) is a pleiotropic cytokine involved in many physiological and pathological processes. LIF is highly expressed in a subset of tumors across multiple tumor types and has been shown to correlate with poor prognosis. LIF i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::043ef42ed2f35c065a68d3468f5271fb
https://doi.org/10.1158/1535-7163.targ-17-lb-b34

Findings from Merck Healthcare KGaA Yields New Data on Biotechnology (Discovery of Cycloalkyl[C]Thiophenes As Novel Scaffolds for Hypoxia-inducible Factor-2 & Alpha; Inhibitors).

Publikováno v: Cancer Weekly; 8/8/2023, p247-247, 1p