Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Ada Popolo"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7477 (2024)
Cardiotoxicity is the main side effect of several chemotherapeutic drugs. Doxorubicin (Doxo) is one of the most used anthracyclines in the treatment of many tumors, but the development of acute and chronic cardiotoxicity limits its clinical usefulnes
Externí odkaz:
https://doaj.org/article/20a5d19a2813405d83a0d00e5647f715
Autor:
Michela Pecoraro, Stefania Marzocco, Raffaella Belvedere, Antonello Petrella, Silvia Franceschelli, Ada Popolo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7573 (2023)
This study aimed to evaluate if Simvastatin can reduce, and/or prevent, Doxorubicin (Doxo)-induced cardiotoxicity. H9c2 cells were treated with Simvastatin (10 µM) for 4 h and then Doxo (1 µM) was added, and the effects on oxidative stress, calcium
Externí odkaz:
https://doaj.org/article/5994b4a61a0b4a648e2f034134b60a26
Autor:
Raluca Maria Pop, Adrian Pavel Trifa, Ada Popolo, Veronica Sanda Chedea, Claudia Militaru, Ioana Corina Bocsan, Anca Dana Buzoianu
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 23, Iss 6, Pp 699-713 (2020)
Objective(s): Over the past 20 years, increasing interest in the use of medicinal plants as alternative or adjuvant treatments of several chronic diseases was observed. Accordingly, Nigella sativa or black cumin, a medicinal plant rich in bioactive c
Externí odkaz:
https://doaj.org/article/4f64076ff28b4aa294f677a1f5b83626
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6375 (2022)
Human epidermal growth factor receptor-2 (HER2) is overexpressed in up to 30% of breast cancer cases, causing a more aggressive tumour growth and poor prognosis. Trastuzumab, the humanized antibody targeted to HER2, increased the life expectancy of p
Externí odkaz:
https://doaj.org/article/1427fa81eca74bd48aa762d0ecb6f808
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11599 (2021)
Hypoxia is the leading cause of death in cardiomyocytes. Cells respond to oxygen deprivation by activating cytoprotective programs, such as mitochondrial connexin43 (mCx43) overexpression and the opening of mitochondrial KATP channels, aimed to reduc
Externí odkaz:
https://doaj.org/article/6340248dda6749b58ad770d5bd502cd4
Autor:
Shara Francesca Rapa, Francesco Prisco, Ada Popolo, Valentina Iovane, Giuseppina Autore, Biagio Raffaele Di Iorio, Fabrizio Dal Piaz, Orlando Paciello, Fuyu Nishijima, Stefania Marzocco
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1135 (2021)
The intestines are recognized as the main source of chronic inflammation in chronic kidney disease (CKD) and, among other cells, macrophages are involved in modulating this process as well as in the impaired immune response which also occurs in CKD p
Externí odkaz:
https://doaj.org/article/0e81400e7a9f46f7993370aba4d7444c
Autor:
Raluca Maria Pop, Ioana Corina Bocsan, Anca Dana Buzoianu, Veronica Sanda Chedea, Sonia Ancuța Socaci, Michela Pecoraro, Ada Popolo
Publikováno v:
Molecules, Vol 25, Iss 22, p 5259 (2020)
Natural products black cumin—Nigella sativa (N. sativa) and wild garlic—Allium ursinum (AU) are known for their potential role in reducing cardiovascular risk factors, including antracycline chemotherapy. Therefore, this study investigates the ef
Externí odkaz:
https://doaj.org/article/e78337d1620f43cea98b35375ede5356
Autor:
Gianluigi De Falco, Chiara Colarusso, Michela Terlizzi, Ada Popolo, Michela Pecoraro, Mario Commodo, Patrizia Minutolo, Mariano Sirignano, Andrea D’Anna, Rita P. Aquino, Aldo Pinto, Antonio Molino, Rosalinda Sorrentino
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Chronic obstructive pulmonary disease (COPD) is considered the fourth-leading causes of death worldwide; COPD is caused by inhalation of noxious indoor and outdoor particles, especially cigarette smoke that represents the first risk factor for this r
Externí odkaz:
https://doaj.org/article/4ca57dbcbe1a4372be4222b6c082c89d
Autor:
Simona Adesso, Marco Ruocco, Shara Francesca Rapa, Fabrizio Dal Piaz, Biagio Raffaele Di Iorio, Ada Popolo, Giuseppina Autore, Fuyu Nishijima, Aldo Pinto, Stefania Marzocco
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2280 (2019)
Chronic kidney disease (CKD) is characterized by an oxidative stress status, driving some CKD-associated complications, even at the gastrointestinal level. Indoxyl Sulfate (IS) is a protein-bound uremic toxin, poorly eliminated by dialysis. This toxi
Externí odkaz:
https://doaj.org/article/56ee2548992743b9964d27c8240257de
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1698 (2019)
Heart failure is a complex clinical syndrome involving a multitude of neurohormonal pathways including the renin-angiotensin-aldosterone system, sympathetic nervous system, and natriuretic peptides system. It is now emerging that neurohumoral mechani
Externí odkaz:
https://doaj.org/article/d626b47f81a3451fb070bb717bb42dba