Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ada Nowosad"'
Autor:
Justine Creff, Ada Nowosad, Anne Prel, Anne Pizzoccaro, Marion Aguirrebengoa, Nicolas Duquesnes, Caroline Callot, Thomas Jungas, Christine Dozier, Arnaud Besson
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112659- (2023)
Summary: p57Kip2 is a cyclin/CDK inhibitor and a negative regulator of cell proliferation. Here, we report that p57 regulates intestinal stem cell (ISC) fate and proliferation in a CDK-independent manner during intestinal development. In the absence
Externí odkaz:
https://doaj.org/article/b1a81f90266345afb1547f5894d6c8fa
Autor:
Ada Nowosad, Justine Creff, Pauline Jeannot, Raphael Culerrier, Patrice Codogno, Stephane Manenti, Laurent Nguyen, Arnaud Besson
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-18 (2021)
Abstract The cyclin-dependent kinase inhibitor p27Kip1 (p27) has been involved in promoting autophagy and survival in conditions of metabolic stress. While the signaling cascade upstream of p27 leading to its cytoplasmic localization and autophagy in
Externí odkaz:
https://doaj.org/article/3f8632b3d79c4c818e87cd22b059628d
Autor:
Ada Nowosad, Arnaud Besson
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100966- (2021)
Summary: Autophagy measurement has been challenging due to the transient nature of autophagy vesicles, in which degradation of cargo occurs. Here, we present a protocol to monitor starvation-induced autophagy using a live high-throughput microscopy s
Externí odkaz:
https://doaj.org/article/4fd57986613f436d96f10c6836e8d563
Autor:
Pauline Jeannot, Ada Nowosad, Renaud T Perchey, Caroline Callot, Evangeline Bennana, Takanori Katsube, Patrick Mayeux, François Guillonneau, Stéphane Manenti, Arnaud Besson
Publikováno v:
eLife, Vol 6 (2017)
p27Kip1 (p27) is a cyclin-CDK inhibitor and negative regulator of cell proliferation. p27 also controls other cellular processes including migration and cytoplasmic p27 can act as an oncogene. Furthermore, cytoplasmic p27 promotes invasion and metast
Externí odkaz:
https://doaj.org/article/37a08fddd7294cc1a8109c4770f88350
Autor:
Panagiotis Karras, Ignacio Bordeu, Joanna Pozniak, Ada Nowosad, Cecilia Pazzi, Nina Van Raemdonck, Ewout Landeloos, Yannick Van Herck, Dennis Pedri, Greet Bervoets, Samira Makhzami, Jia Hui Khoo, Benjamin Pavie, Jochen Lamote, Oskar Marin-Bejar, Michael Dewaele, Han Liang, Xingju Zhang, Yichao Hua, Jasper Wouters, Robin Browaeys, Gabriele Bergers, Yvan Saeys, Francesca Bosisio, Joost van den Oord, Diether Lambrechts, Anil K. Rustgi, Oliver Bechter, Cedric Blanpain, Benjamin D. Simons, Florian Rambow, Jean-Christophe Marine
Although melanoma is notorious for its high degree of heterogeneity and plasticity1,2, the origin and magnitude of cell-state diversity remains poorly understood. Equally, it is unclear whether growth and metastatic dissemination are supported by ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a0f034744ad4e5fbde61c850381cb1
Autor:
Justine Creff, Ada Nowosad, Anne Prel, Anne Pizzoccaro, Marion Aguirrebengoa, Nicolas Duquesnes, Caroline Callot, Thomas Jungas, Christine Dozier, Arnaud Besson
p57Kip2 is a cyclin/CDK inhibitor and a negative regulator of cell proliferation. Remarkably, p57 is the only CDK inhibitor required for embryonic development and p57 knockout mice display multiple developmental anomalies, including intestinal shorte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cb9653c7b1b4d9865c8e67e5b3750ba
https://doi.org/10.1101/2022.09.09.507138
https://doi.org/10.1101/2022.09.09.507138
Autor:
Arnaud Besson, Ada Nowosad
Publikováno v:
International journal of molecular sciences. 23(4)
Initially described as lytic bodies due to their degradative and recycling functions, lysosomes play a critical role in metabolic adaptation to nutrient availability. More recently, the contribution of lysosomal proteins to cell signaling has been es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247b120f3885132ba78e78158f64fc9c
https://pubmed.ncbi.nlm.nih.gov/35216401
https://pubmed.ncbi.nlm.nih.gov/35216401
Autor:
Panagiotis Karras, Ignacio Bordeu, Joanna Pozniak, Ada Nowosad, Cecilia Pazzi, Nina Van Raemdonck, Ewout Landeloos, Yannick Van Herck, Dennis Pedri, Greet Bervoets, Samira Makhzami, Jia Hui Khoo, Benjamin Pavie, Jochen Lamote, Oskar Marin-Bejar, Michael Dewaele, Han Liang, Xingju Zhang, Yichao Hua, Jasper Wouters, Robin Browaeys, Gabriele Bergers, Yvan Saeys, Francesca Bosisio, Joost van den Oord, Diether Lambrechts, Anil K. Rustgi, Oliver Bechter, Cedric Blanpain, Benjamin D. Simons, Florian Rambow, Jean-Christophe Marine
in press
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c64a9e87f62a794b34c463954b47ed
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85140103853
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85140103853
Autor:
Joanna Pozniak, Dennis Pedri, Ewout Landeloos, Yannick Van Herck, Asier Antoranz, Panagiotis Karras, Ada Nowosad, Samira Makhzami, Greet Bervoets, Michael Dewaele, Lukas Vanwynsberghe, Sonia Cinque, Sam Kint, Katy Vandereyken, Thierry Voet, Frank Vernaillen, Wim Annaert, Diether Lambrechts, Veerle Boecxstaens, Joost van den Oord, Francesca Bosisio, Eleonora Leucci, Florian Rambow, Oliver Bechter, Jean-Christophe Marine
Publikováno v:
bioRxiv
Primary resistance drastically limits the clinical success of immune checkpoint blockade (ICB) in melanoma. Resistance to ICB may also develop when tumours relapse after targeted therapy. To identify cancer cell-intrinsic mechanisms driving resistanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51e62238927c07e8fe3fab8246d1c8c
Autor:
Ada Nowosad, Caroline Callot, Carine Joffre, Arnaud Besson, Stéphane Manenti, Patrice Codogno, Pauline Jeannot, Justine Creff, Renaud T. Perchey
Publikováno v:
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2020, 22 (9), pp.1076-1090. ⟨10.1038/s41556-020-0554-4⟩
Nature Cell Biology, Nature Publishing Group, 2020, 22 (9), pp.1076-1090. ⟨10.1038/s41556-020-0554-4⟩
International audience; Autophagy is a catabolic process whereby cytoplasmic components are degraded within lysosomes, allowing cells to maintain energy homeostasis during nutrient depletion. Several studies reported that the CDK inhibitor p27Kip1 pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94e1a946c85d0a3567d7dd5c51cec58
https://hal.archives-ouvertes.fr/hal-02989025
https://hal.archives-ouvertes.fr/hal-02989025