Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ada Kung"'
Autor:
Ying Tan, Ada Kung, Zhihua Huang, Bo Qi, Xinfeng Zhang, Yumin Cui, Zaiqing Wen, Lan Luo, Xiaoqiang Yan, Shen Wuzhong, Hanyang Chen, Yun Wu
Publikováno v:
Blood. 132:4169-4169
Immunotherapies targeting B-lineage-specific surface marker CD19 had demonstrated promising clinical results. Two CD19 CAR-T therapies (Kymriah® and Yescarta®) have been approved by FDA to treat patients with B cell malignancies, however, the compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01d90642abca8a1041fd8e890ba5f3a7
https://doi.org/10.1182/blood-2018-99-112819
https://doi.org/10.1182/blood-2018-99-112819
Synthetic Erythropoietic Proteins: Tuning Biological Performance by Site-Specific Polymer Attachment
Autor:
E. Neil Cagle, Maia Carnevali, John W. Adamson, Vincent Gueriguian, Carlos E. Bozzini, Gerd G. Kochendoerfer, Sonya Cressman, James A. Bradburne, Ada Kung, M. Con Wiedeke, Heather Porter, Laura Savatski, Stephen M. Stratton, Feng Mao, Haiyan Shao, Donald W. Low, Stephen B. H. Kent, Shiah-Yun Chen, Peter J. Keogh, Hal S. Beilan
Publikováno v:
Chemistry & Biology. 12(3):371-383
SummaryChemical synthesis in combination with precision polymer modification allows the systematic exploration of the effect of protein properties, such as charge and hydrodynamic radius, on potency using defined, homogeneous conjugates. A series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9455f5c2578524928fd3f5cbf800ce2c
Autor:
Les P. Miranda, Ada Kung, Xavier Paliard, Yvonne Chinn, Rod Garcia, Maia Carnevali, Bill O'dwyer, Di Song, Jill Wilken, Donald E. Low, Ting Kong, Gerd G. Kochendoerfer, Jay Ye, Shiah-Yun Chen, James A. Bradburne, Alex Taekyung Lee, Jason Williams, Haiyan Shao, E. Neil Cagle, Nathalie Fraud
Publikováno v:
Journal of the American Chemical Society. 129(43)
Chemical protein synthesis is important for dissecting the molecular basis of protein function. Here we advance its scope by demonstrating the significant improvement of the multifaceted pharmaceutical profile of small proteins exclusively via a chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c25beaef3234beabb2cc4151e03a4ad
https://pubmed.ncbi.nlm.nih.gov/17915868
https://pubmed.ncbi.nlm.nih.gov/17915868
Autor:
Haiyan Shao, Sonya Cressman, John W. Adamson, Vincent Gueriguian, Paolo Botti, Suresh Kalbag, Peter J. Keogh, Laura Savatski, Janice Schindler-Horvat, James A. Bradburne, Donald W. Low, Les P. Miranda, Stephen B. H. Kent, Stacey Traviglia, Feng Mao, Christie L. Hunter, Jay J. Levy, Milan M. Crnogorac, Jill Wilken, Gerd G. Kochendoerfer, Heather Porter, E. Neil Cagle, Ada Kung, Stephen M. Stratton, Shiah-Yun Chen, Maia Carnevali, Jie Tang, M. Con Wiedeke
Publikováno v:
Science (New York, N.Y.). 299(5608)
We report the design and total chemical synthesis of “synthetic erythropoiesis protein” (SEP), a 51-kilodalton protein-polymer construct consisting of a 166-amino–acid polypeptide chain and two covalently attached, branched, and monodisperse po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24473ee266ab5a0bf2ce5d7d6753ca51
https://pubmed.ncbi.nlm.nih.gov/12574628
https://pubmed.ncbi.nlm.nih.gov/12574628
Publikováno v:
Critical Care Medicine. 21:S286
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4033a1be0a98754ea4986c332515a76
https://doi.org/10.1097/00003246-199304001-00303
https://doi.org/10.1097/00003246-199304001-00303