Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ada King"'
Publikováno v:
Biochemistry. 56:6434-6447
Small molecules that modulate biological functions are targets of modern day drug discovery efforts. In a common platform fragment-based drug discovery, two fragments that bind to adjacent sites on a target are identified and are then linked together
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a604001cac701a92fbdacd3c66df51f
https://doi.org/10.1021/acs.biochem.7b00929
https://doi.org/10.1021/acs.biochem.7b00929
Autor:
Dev P. Arya, Fenfei Leng, Weidong Wang, Nihar Ranjan, Yuk-Ching Tse-Dinh, Geraldine Fulcrand, Sandra Story, Souvik Sur, Ada King, Muzammil Ahmad
Publikováno v:
Journal of Medicinal Chemistry. 60:4904-4922
A series of Hoechst 33258 based mono- and bisbenzimidazoles have been synthesized and their Escherichia coli DNA topoisomerase I inhibition, binding to B-DNA duplex, and antibacterial activity has been evaluated. Bisbenzimidazoles with alkynyl side c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7df45b7862bf1ed96fad95a2d11871
https://doi.org/10.1021/acs.jmedchem.7b00191
https://doi.org/10.1021/acs.jmedchem.7b00191
Autor:
Arren Z. Washington, Ada King, Derrick Watkins, Keith D. Green, Sylvie Garneau-Tsodikova, Yi Jin, Changjun Gong, Liuwei Jiang, Adegboyega K. Oyelere, Dev P. Arya
Publikováno v:
ACS Chemical Biology. 10:1278-1289
A 215-member mono- and diamino acid peptidic-aminosugar (PA) library, with neomycin as the model aminosugar, was systematically and rapidly synthesized via solid phase synthesis. Antibacterial activities of the PA library, on 13 bacterial strains (se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30548aa9bc082d1d7ff21ce9b8fb067a
https://doi.org/10.1021/cb5010367
https://doi.org/10.1021/cb5010367
Autor:
Xiuping Jiang, Nihar Ranjan, Fenfei Leng, Geraldine Fulcrand, Dev P. Arya, Joseph C. Brown, Ada King
Publikováno v:
Med. Chem. Commun.. 5:816-825
Hoechst dyes are well known DNA binders that non-selectively inhibit the function of mammalian topoisomerase I and II. Herein, we show that Hoechst 33258 based bisbenzimidazoles (DPA 151–154), containing a terminal alkyne, are effective and selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75531ed3cef1ed6c31b6e888ee727a86
https://doi.org/10.1039/c4md00140k
https://doi.org/10.1039/c4md00140k
Autor:
Dev P. Arya, Sunil Kumar, Changjun Gong, Nihar Ranjan, Ada King, Derrick Watkins, Jarred Whitlock
Publikováno v:
Antimicrobial agents and chemotherapy. 57(10)
We report here the affinity and antibacterial activity of a structurally similar class of neomycin dimers. The affinity of the dimer library for rRNA was established by using a screen that measures the displacement of fluorescein-neomycin (F-neo) pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8c1b8c51511c2253feb6749aa5ac81
https://pubmed.ncbi.nlm.nih.gov/23856777
https://pubmed.ncbi.nlm.nih.gov/23856777