Výsledky vyhledávání - "Ada I. C. Wong"

Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing

Autor: Suk Hang Cheng, Rossa W.K. Chiu, Tak Yeung Leung, Kun Sun, Yvonne Kwun Yue Cheng, Peiyong Jiang, Ada I. C. Wong, Haiqiang Zhang, Y.M. Dennis Lo, K.C. Allen Chan

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Cell-free DNA molecules in the plasma of pregnant women exhibit nonrandom fragmentation with preferred end sites. We studied if such preferred end sites might bear any relationship with fragment lengths of plasma DNA. Short and long plas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abbdcf92c390b1c9b441e455f976238
https://doi.org/10.1073/pnas.1804134115

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Second generation noninvasive fetal genome analysis reveals de novo mutations, single-base parental inheritance, and preferred DNA ends

Autor: Yuk Ming Dennis Lo, Irena Hudecova, Rossa W.K. Chiu, K.C. Allen Chan, Peiyong Jiang, Yu K. Tong, Tak Yeung Leung, Ada I. C. Wong, Kun Sun, Yvonne Kwun Yue Cheng, Suk Hang Cheng

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 113(50)

Plasma DNA obtained from a pregnant woman was sequenced to a depth of 270× haploid genome coverage. Comparing the maternal plasma DNA sequencing data with the parental genomic DNA data and using a series of bioinformatics filters, fetal de novo muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4683c0973e63379fc086dfe56c0a61
https://pubmed.ncbi.nlm.nih.gov/27911833

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