Design and synthesis of backbone cyclic phosphorylated peptides: The IκB model

Autor: Deborah E. Shalev, Chaim Gilon, Assaf Friedler, Yinon Ben-Neriah, Nir Qvit, Ada Hatzubai

Publikováno v: Biopolymers. 91:157-168

Phosphopeptides have been used to study phosphorylation and dephosphorylation, which are key events in protein expression. Backbone cyclization has been shown to increase the stability and selectivity of peptides. Backbone cyclic peptides with confor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e260272808cbf9ae11b279da6ef917
https://doi.org/10.1002/bip.21098

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

Autor: Aaron Ciechanover, Amir Orian, Ada Hatzubai, Avraham Yaron, Yinon Ben-Neriah, Irit Alkalay

Publikováno v: Proceedings of the National Academy of Sciences. 92:10599-10603

The nuclear translocation of NF-kappa B follows the degradation of its inhibitor, I kappa B alpha, an event coupled with stimulation-dependent inhibitor phosphorylation. Prevention of the stimulation-dependent phosphorylation of I kappa B alpha, eith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6291bed9b72157f10cbd6b3514569e8
https://doi.org/10.1073/pnas.92.23.10599

Design and Synthesis of Backbone Cyclic Phosphopeptides: The IκB Model

Autor: Deborah E. Shalev, Chaim Gilon, Nir Qvit, Yinon Ben-Neriah, Ada Hatzubai

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9780387736563

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9e72e4511055dc95ff1e68934c6107b
https://doi.org/10.1007/978-0-387-73657-0_62

Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U

Autor: Etti Ben-Shushan, Matthias Mann, Avraham Yaron, Frank Mercurio, Matti Davis, Yinon Ben-Neriah, Gregory Zvi Fisher, Asne R. Bauskin, Jens S. Andersen, Ada Hatzubai

Publikováno v: Davis, M, Hatzubai, A, Andersen, J S, Ben-Shushan, E, Fisher, G Z, Yaron, A, Bauskin, A, Mercurio, F, Mann, M & Ben-Neriah, Y 2002, ' Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U ', Genes & Development, vol. 16, no. 4, pp. 439-51 . https://doi.org/10.1101/gad.218702

β-TrCP/E3RS (E3RS) is the F-box protein that functions as the receptor subunit of the SCFβ-TrCP ubiquitin ligase (E3). Surprisingly, although its two recognized substrates, IκBα and β-catenin, are present in the cytoplasm, we have found that E3R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf69ea79ab8fa6e3c58bd1846a3f8cb
https://portal.findresearcher.sdu.dk/da/publications/ce5a4510-ba98-11dc-9626-000ea68e967b

Down-regulation of the EBV-encoded membrane protein (LMP) in burkitt lymphomas

Autor: Richard A. Lerner, Ada Hatzubai, Dov Sulitzeanu, M. G. Masucci, Joakim Dillner, George Klein, M. Anafi

Publikováno v: International Journal of Cancer. 40:358-364

A radioimmunoassay (RIA) has been developed and used to determine the expression of LMP-a membrane protein encoded by the LT3 region of the Epstein-Barr virus (EBV) genome-in cell lines of various origins. The RIA was highly sensitive, specific and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5282d09414dd5cfc0dbc26fb332c0e
https://doi.org/10.1002/ijc.2910400313