Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis.

Autor: Ada Fiorini, Tatiana Koudriavtseva, Elona Bucaj, Raffaella Coccia, Cesira Foppoli, Alessandra Giorgi, M Eugenia Schininà, Fabio Di Domenico, Federico De Marco, Marzia Perluigi

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65184 (2013)

Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system. Several evidences suggest that MS can be considered a multi-factorial disease in which both genetics and environmental factors are involved. Am

Externí odkaz: https://doaj.org/article/f1e686038c264d9ea7c1d9d667679d56

Oxidative stress in HPV-driven viral carcinogenesis: redox proteomics analysis of HPV-16 dysplastic and neoplastic tissues.

Autor: Federico De Marco, Elona Bucaj, Cesira Foppoli, Ada Fiorini, Carla Blarzino, Kozeta Filipi, Alessandra Giorgi, Maria Eugenia Schininà, Fabio Di Domenico, Raffaella Coccia, D Allan Butterfield, Marzia Perluigi

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e34366 (2012)

Genital infection by high risk Human Papillomavirus (HR-HPV), although recognized as the main etio-pathogenetic factor of cervical cancer, is not per se sufficient to induce tumour development. Oxidative stress (OS) represents an interesting and unde

Externí odkaz: https://doaj.org/article/8cea8b1ffaa74b3ba7ce7fafda072372

Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: A proteomics study

Autor: Sarah Förster, Marzia Perluigi, Giovanna Cenini, Susan A. Farr, John E. Morley, Ada Fiorini, Vijaya B. Kumar, Rukhsana Sultana, Jian Cai, Michael L. Niehoff, Chiara Cini, D. Allan Butterfield, Jon B. Klein

Publikováno v: Free Radical Biology and Medicine. 65:1-14

Amyloid β-peptide (Aβ) plays a central role in the pathophysiology of Alzheimer's disease (AD) through the induction of oxidative stress. This peptide is produced by proteolytic cleavage of amyloid precursor protein (APP) by the action of β- and �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95c1bd7353ee2419b38318499ada559
https://doi.org/10.1016/j.freeradbiomed.2013.06.017

Involvement of Oxidative Stress in Occurrence of Relapses in Multiple Sclerosis: The Spectrum of Oxidatively Modified Serum Proteins Detected by Proteomics and Redox Proteomics Analysis

Autor: M. Eugenia Schininà, Federico De Marco, Fabio Di Domenico, Raffaella Coccia, Elona Bucaj, Ada Fiorini, Alessandra Giorgi, Tatiana Koudriavtseva, Cesira Foppoli, Marzia Perluigi

Publikováno v: PLoS ONE
PloS one 8 (2013). doi:10.1371/journal.pone.0065184
info:cnr-pdr/source/autori:Fiorini, A; Koudriavtseva, T; Bucaj, E; Coccia, R; Foppoli, C; Giorgi, A; Schinina, ME; Di Domenico, F; De Marco, F ; Perluigi, M/titolo:Involvement of Oxidative Stress in Occurrence of Relapses in Multiple Sclerosis: The Spectrum of Oxidatively Modified Serum Proteins Detected by Proteomics and Redox Proteomics Analysis/doi:10.1371%2Fjournal.pone.0065184/rivista:PloS one/anno:2013/pagina_da:/pagina_a:/intervallo_pagine:/volume:8
PLoS ONE, Vol 8, Iss 6, p e65184 (2013)

Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system. Several evidences suggest that MS can be considered a multi-factorial disease in which both genetics and environmental factors are involved. Am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cc83401278f925f6ca21d99ff97234
http://hdl.handle.net/11573/524902

Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis?

Autor: Austin S. Baker, Renã A. S. Robinson, Rukhsana Sultana, Ada Fiorini, Miranda L. Bader Lange, Veronica Galvan, Joanna Fombonne, Jian Cai, William M. Pierce, Dale E. Bredesen, D. Allan Butterfield, Junli Zhang, Olivia Gorostiza

Publikováno v: Antioxidantsredox signaling. 17(11)

The single methionine (Met/M) residue of amyloid-beta (Aβ) peptide, at position 35 of the 42-mer, has important relevance for Aβ-induced oxidative stress and neurotoxicity. Recent in vivo brain studies in a transgenic (Tg) Alzheimer disease (AD) mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18617f6b3975612e08b08584f24b195a
https://pubmed.ncbi.nlm.nih.gov/22500616