Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Adéla Nacer"'
Autor:
Manuela C. Aguirre-Botero, Lawrence T. Wang, Pauline Formaglio, Eduardo Aliprandini, Jean-Michel Thiberge, Arne Schön, Yevel Flores-Garcia, Shamika Mathis-Torres, Barbara J. Flynn, Lais da Silva Pereira, Yann Le Duff, Mathew Hurley, Adéla Nacer, Paul W. Bowyer, Fidel Zavala, Azza H. Idris, Joseph R. Francica, Robert A. Seder, Rogerio Amino
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112681- (2023)
Summary: Human monoclonal antibodies (hmAbs) targeting the Plasmodium falciparum circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for preventing malaria infection. However, their mechanisms of protection remain unclear.
Externí odkaz:
https://doaj.org/article/0e7fe2937927407cbebd3d4c244d9741
Autor:
Robert J. Ragotte, David Pulido, Amelia M. Lias, Doris Quinkert, Daniel G. W. Alanine, Abhishek Jamwal, Hannah Davies, Adéla Nacer, Edward D. Lowe, Geoffrey W. Grime, Joseph J. Illingworth, Robert F. Donat, Elspeth F. Garman, Paul W. Bowyer, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Antibodies can have synergistic effects, but mechanisms are not well understood. Here, Ragotte et al. identify three antibodies that bind neighbouring epitopes on CyRPA, a malaria vaccine candidate, and show that lateral interactions between the anti
Externí odkaz:
https://doaj.org/article/311198660694450bbebda7b48bd4d1b2
Autor:
Adéla Nacer, Gaily Kivi, Raini Pert, Erkki Juronen, Pavlo Holenya, Eduardo Aliprandini, Rogerio Amino, Olivier Silvie, Doris Quinkert, Yann Le Duff, Matthew Hurley, Ulf Reimer, Andres Tover, Simon J. Draper, Sarah Gilbert, Mei Mei Ho, Paul W. Bowyer
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Malaria, an infection caused by apicomplexan parasites of the genus Plasmodium, continues to exact a significant toll on public health with over 200 million cases world-wide, and annual deaths in excess of 600,000. Considerable progress has been made
Externí odkaz:
https://doaj.org/article/964ca94ca03a4486ab7310ec1cba72cb
Autor:
Adéla Nacer, Alexandru Movila, Fabien Sohet, Natasha M Girgis, Uma Mahesh Gundra, P'ng Loke, Richard Daneman, Ute Frevert
Publikováno v:
PLoS Pathogens, Vol 10, Iss 12, p e1004528 (2014)
Cerebral malaria claims the lives of over 600,000 African children every year. To better understand the pathogenesis of this devastating disease, we compared the cellular dynamics in the cortical microvasculature between two infection models, Plasmod
Externí odkaz:
https://doaj.org/article/9495ebb347c64c379ac2f0f8a8cc99df
Autor:
Adéla Nacer, Emeric Roux, Sébastien Pomel, Christine Scheidig-Benatar, Hiroshi Sakamoto, Frank Lafont, Artur Scherf, Denise Mattei
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29039 (2011)
BACKGROUND: The expression of the clonally variant virulence factor PfEMP1 mediates the sequestration of Plasmodium falciparum infected erythrocytes in the host vasculature and contributes to chronic infection. Non-cytoadherent parasites with a chrom
Externí odkaz:
https://doaj.org/article/91eb9b20d6804940b625d66cc4217545
Autor:
Robert J, Ragotte, David, Pulido, Amelia M, Lias, Doris, Quinkert, Daniel G W, Alanine, Abhishek, Jamwal, Hannah, Davies, Adéla, Nacer, Edward D, Lowe, Geoffrey W, Grime, Joseph J, Illingworth, Robert F, Donat, Elspeth F, Garman, Paul W, Bowyer, Matthew K, Higgins, Simon J, Draper
Publikováno v:
Nature communications. 13(1)
Understanding mechanisms of antibody synergy is important for vaccine design and antibody cocktail development. Examples of synergy between antibodies are well-documented, but the mechanisms underlying these relationships often remain poorly understo
Autor:
Christine Scheidig-Benatar, Jose-Juan Lopez-Rubio, Adéla Nacer, Aurélie Claes, Denise Mattei, Amy Roberts, Hiroshi Sakamoto, Mehdi Ghorbal
Publikováno v:
Cellular Microbiology. 17:1205-1216
Plasmodium falciparum virulence is linked to its ability to sequester in post-capillary venules in the human host. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is the main variant surface antigen implicated in this process. Complete
Publikováno v:
Parasitology International. 63:171-186
Plasmodium falciparum malaria is responsible for the deaths of over half a million African children annually. Until a decade ago, dynamic analysis of the malaria parasite was limited to in vitro systems with the typical limitations associated with 2D
Publikováno v:
Cellular Microbiology. 21:e13024
Intravital fluorescence microscopy (IVM) is a powerful technique for imaging multiple organs, including the brain of living mice and rats. It enables the direct visualisation of cells in situ providing a real-life view of biological processes that in
Publikováno v:
International Journal for Parasitology. 31:1371-1379
The malaria parasite, Plasmodium falciparum, synthesises and exports several proteins inducing morphological and biochemical modifications of erythrocytes during the erythrocytic cycle. The protein trafficking machinery of the parasite is similar to