Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Adéla Krajčová"'
Effect of noradrenaline on propofol-induced mitochondrial dysfunction in human skeletal muscle cells
Autor:
Adéla Krajčová, Christine Skagen, Valér Džupa, Tomáš Urban, Arild C. Rustan, Kateřina Jiroutková, Bohumil Bakalář, G. Hege Thoresen, František Duška
Publikováno v:
Intensive Care Medicine Experimental, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Background Mitochondrial dysfunction is a hallmark of both critical illness and propofol infusion syndrome and its severity seems to be proportional to the doses of noradrenaline, which patients are receiving. We comprehensively studied the
Externí odkaz:
https://doaj.org/article/b82e34584bbd453fa2f2d26a2cf87767
Autor:
Adéla Krajčová, Tomáš Urban, David Megvinet, Petr Waldauf, Martin Balík, Jan Hlavička, Petr Budera, Libor Janoušek, Eva Pokorná, František Duška
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226142 (2020)
Impaired myocardial bioenergetics is a hallmark of many cardiac diseases. There is a need of a simple and reproducible method of assessment of mitochondrial function from small human myocardial tissue samples. In this study we adopted high-resolution
Externí odkaz:
https://doaj.org/article/c0eb9cd360f341e3aaadd8a07cba0961
Autor:
Jan Gojda, Petr Waldauf, Natália Hrušková, Barbora Blahutová, Adéla Krajčová, Tomáš Urban, Petr Tůma, Kamila Řasová, František Duška
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0200228 (2019)
BACKGROUND:Aim of the study was to compare metabolic response of leg skeletal muscle during functional electrical stimulation-driven unloaded cycling (FES) to that seen during volitional supine cycling. METHODS:Fourteen healthy volunteers were expose
Externí odkaz:
https://doaj.org/article/59b7f4c4cc5a4007a397b8711a1c64cb
Autor:
Tomáš Urban, Petr Waldauf, Adéla Krajčová, Kateřina Jiroutková, Milada Halačová, Valér Džupa, Libor Janoušek, Eva Pokorná, František Duška
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0217254 (2019)
IntroductionPropofol causes a profound inhibition of fatty acid oxidation and reduces spare electron transfer chain capacity in a range of human and rodent cells and tissues-a feature that might be related to the pathogenesis of Propofol Infusion Syn
Externí odkaz:
https://doaj.org/article/9740716d94e94138821375a14220b50e
Autor:
Tom S. O. Jameson, Benjamin T. Wall, Tomáš Urban, Adéla Krajčová, Bob Bakalář, Michal Fric, Kateřina Jiroutková, Valér Džupa, Jan Gojda, Craig Porter, Barbora Miznerová, František Duška, Francis B. Stephens
The association of perturbed skeletal muscle metabolism with ICU acquired weakness (ICUAW) is not clear. We characterised temporal changes in skeletal muscle mitochondrial function, ATP concentration, and substrate utilisation during and up to 6 mont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1645edc9b3cca666bb53c67f6e5e0eb6
https://doi.org/10.21203/rs.3.rs-2807805/v1
https://doi.org/10.21203/rs.3.rs-2807805/v1
Autor:
Kamila Řasová, Barbora Blahutová, Tomáš Urban, Petr Waldauf, František Duška, Adéla Krajčová, Marcela Grünerová-Lippertová, Kateřina Jiroutková, Jan Gojda, Bob Bakalář
Publikováno v:
Journal of Parenteral and Enteral Nutrition. 46:249-253
BACKGROUND Functional electrical stimulation-assisted cycle ergometry (FESCE) can deliver active exercise to critically ill patients, including those who are sedated. Aerobic exercise is known to stimulate skeletal muscle glucose uptake. We asked whe
Publikováno v:
Critical Care Medicine.
OBJECTIVES To assess the impact of rehabilitation in ICU on clinical outcomes. DATA SOURCES Secondary data analysis of randomized controlled trials published between 1998 and October 2019 was performed in accordance with Preferred Reporting Items for
Autor:
Eva Pokorna, Libor Janousek, Tomáš Urban, František Duška, Petr Waldauf, V Dzupa, Adéla Krajčová, Milada Halačová, Kateřina Jiroutková
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0217254 (2019)
PLoS ONE, Vol 14, Iss 10, p e0217254 (2019)
IntroductionPropofol causes a profound inhibition of fatty acid oxidation (FAO) and reduces spare electron transfer chain (ETC) capacity in a range of human and rodent cells and tissues – a feature that might be related to the pathogenesis of Propo
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Cardiolipin (CL) is a multifunctional dimeric phospholipid that physically interacts with electron transport chain complexes I, III, and IV, and ATP synthase (complex V). The enzyme ALCAT1 catalyzes the conversion of cardiolipin by incorporating poly