CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors

Autor: Roxane Van Heurck, Jérôme Bonnefont, Marta Wojno, Ikuo K. Suzuki, Fausto D. Velez-Bravo, Emir Erkol, Dan Truc Nguyen, Adèle Herpoel, Angéline Bilheu, Sofie Beckers, Catherine Ledent, Pierre Vanderhaeghen

Publikováno v: Neuron. 111:65-80.e6

The primary cilium is a central signaling component during embryonic development. Here we focus on CROCCP2, a hominid-specific gene duplicate from ciliary rootlet coiled coil (CROCC), also known as rootletin, that encodes the major component of the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed393b801a485202002b6997f139bb6
https://doi.org/10.1016/j.neuron.2022.10.018

Bcl6 promotes neurogenic conversion through transcriptional repression of multiple self-renewal-promoting extrinsic pathways

Autor: Luca Tiberi, Xionghui Lin, Stein Aerts, Jelle van den Ameele, Pierre Vanderhaeghen, Adèle Herpoel, Fausto Damian Velez Bravo, Jérôme Bonnefont, François Guillemot, Angéline Bilheu, Delphine Potier, Zachary Z.B. Gaber

SummaryDuring neurogenesis, progenitors switch from self-renewal to differentiation through the interplay of intrinsic and extrinsic cues, but how these are integrated remains poorly understood. Here we combine whole genome transcriptional and epigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10cc1c8bbbecfbbde77505eb784895a
https://doi.org/10.1101/370999

Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way

Autor: Pierre Vanderhaeghen, Adèle Herpoel, Sandra Acosta-Verdugo, Daniele Linaro, Afsaneh Gaillard, Angéline Bilheu, Ira Espuny-Camacho, Michele Giugliano, Kimmo A. Michelsen

Publikováno v: Cell reports
Cell Reports, Vol 23, Iss 9, Pp 2732-2743 (2018)
Cell Reports
Cell Reports, Elsevier Inc, 2018, 23 (9), pp.2732-2743. ⟨10.1016/j.celrep.2018.04.094⟩
Cell reports, 23 (9

Summary The transplantation of pluripotent stem-cell-derived neurons constitutes a promising avenue for the treatment of several brain diseases. However, their potential for the repair of the cerebral cortex remains unclear, given its complexity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3634cc91c8b3f7edbdb3ed8ec7f4f30
https://lirias.kuleuven.be/handle/123456789/647822

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

Autor: Michael Kyba, Jelle van den Ameele, Adèle Herpoel, Luca Tiberi, Michelina Iacovino, Jordane Dimidschstein, Pierre Vanderhaeghen, Tristan Bouschet, David Gall, Angéline Bilheu, Julie Piccirilli, Jérôme Bonnefont

Publikováno v: Nature Neuroscience. 15:1627-1635

During neurogenesis, neural stem/progenitor cells (NPCs) undergo an irreversible fate transition to become neurons. The Notch pathway is important for this process, and repression of Notch-dependent Hes genes is essential for triggering differentiati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c545bc4f6e205693d97153f21ff15e0
https://doi.org/10.1038/nn.3264

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

Autor: David Gall, Afsaneh Gaillard, Ira Espuny-Camacho, Pierre Vanderhaeghen, Daniele Linaro, Kimmo A. Michelsen, Angéline Bilheu, Serge N. Schiffmann, Adèle Herpoel, Jérôme Bonnefont, Anja Hasche, Michele Giugliano, Nelle Lambert, Sophie Péron, David Orduz, Camilia Bali, Nicolas Gaspard

Publikováno v: Neuron
Neuron, 2013, 77 (3), pp.440-456. ⟨10.1016/j.neuron.2012.12.011⟩
Neuron, Elsevier, 2013, 77 (3), pp.440-456. ⟨10.1016/j.neuron.2012.12.011⟩

International audience; The study of human cortical development has major implications for brain evolution and diseases but has remained elusive due to paucity of experimental models. Here we found that human embryonic stem cells (ESCs) and induced p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6ebacd36a71d004fdc447398a8bbb1
https://hal.archives-ouvertes.fr/hal-02559538