Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma.

Autor: Mbah NE; Chad Carr Pediatric Brain Tumor Center, University of Michigan, Ann Arbor, USA.; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, USA., Myers AL; Chad Carr Pediatric Brain Tumor Center, University of Michigan, Ann Arbor, USA.; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, USA., Sajjakulnukit P; Chad Carr Pediatric Brain Tumor Center, University of Michigan, Ann Arbor, USA.; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, USA., Chung C; Chad Carr Pediatric Brain Tumor Center, University of Michigan, Ann Arbor, USA.; Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, USA.; Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea., Thompson JK; Department of Surgery, University of Michigan, Ann Arbor, USA., Hong HS; Graduate Program in Immunology, University of Michigan, Ann Arbor, USA., Giza H; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, USA., Dang D; Chad Carr Pediatric Brain Tumor Center, University of Michigan, Ann Arbor, USA.; Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, USA.; Graduate Program in Molecular & Cellular Pathology, University of Michigan, Ann Arbor, USA., Nwosu ZC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, USA., Shan M; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, USA., Sweha SR; Chad Carr Pediatric Brain Tumor Center, University of Michigan, Ann Arbor, USA.; Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, USA.; Neuroscience Graduate Program, University of Michigan, Ann Arbor, USA., Maydan DD; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, USA., Chen B; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, USA.; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, USA., Zhang L; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, USA., Magnuson B; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, USA., Zhu Z; Graduate Program in Chemical Biology, University of Michigan, Ann Arbor, USA., Radyk M; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, USA., Lavoie B; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, USA., Yadav VN; The Department of Pediatrics, Children's Mercy Research Institute (CMRI), Kansas, USA., Koo I; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, USA., Patterson AD; Department of Biochemistry and Molecular Biology and Department of Veterinary and Biomedical Sciences, the Pennsylvania State University, University Park, USA., Wahl DR; Chad Carr Pediatric Brain Tumor Center, University of Michigan, Ann Arbor, USA.; Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, USA., Franchi L; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, USA., Agnihotri S; University of Pittsburgh Hillman Cancer Center, Pittsburgh, USA., Koschmann CJ; Chad Carr Pediatric Brain Tumor Center, University of Michigan, Ann Arbor, USA.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, USA., Venneti S; Chad Carr Pediatric Brain Tumor Center, University of Michigan, Ann Arbor, USA. svenneti@med.umich.edu.; Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, USA. svenneti@med.umich.edu.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, USA. svenneti@med.umich.edu.; Department of Pathology, University of Michigan Medical School, Ann Arbor, USA. svenneti@med.umich.edu., Lyssiotis CA; Chad Carr Pediatric Brain Tumor Center, University of Michigan, Ann Arbor, USA. clyssiot@umich.edu.; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, USA. clyssiot@umich.edu.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, USA. clyssiot@umich.edu.; Rogel Cancer Center, University of Michigan, Ann Arbor, USA. clyssiot@umich.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 17; Vol. 15 (1), pp. 8983. Date of Electronic Publication: 2024 Oct 17.

Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation.

Autor: Yokoyama S; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, 16802, USA., Koo I; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, 16802, USA., Aibara D; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Tian Y; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, 16802, USA., Murray IA; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, 16802, USA., Collins SL; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, 16802, USA., Coslo DM; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, 16802, USA., Kono M; Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Peters JM; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, 16802, USA., Proia RL; Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Gonzalez FJ; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Perdew GH; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, 16802, USA., Patterson AD; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, 16802, USA.; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, 16802, USA.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Oct; Vol. 11 (40), pp. e2400794. Date of Electronic Publication: 2024 Aug 29.

Elevated systemic total bile acids escalate susceptibility to alcohol-associated liver disease.

Autor: Paudel D; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA., Hao F; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA., Goand UK; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA., Tian S; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA., Koehle AM 3rd; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA., Nguyen LV Jr; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA., Tian Y; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA., Patterson AD; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA., Singh V; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.; Center for Molecular Immunology and Infectious Disease, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.; One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.

Publikováno v: IScience [iScience] 2024 Sep 13; Vol. 27 (10), pp. 110940. Date of Electronic Publication: 2024 Sep 13 (Print Publication: 2024).

Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice.

Autor: Tian Y; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University (Penn State), University Park, Pennsylvania, USA.; Huck Institutes of the Life Sciences, Penn State, University Park, Pennsylvania, USA., Rimal B; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University (Penn State), University Park, Pennsylvania, USA., Bisanz JE; Department of Biochemistry and Molecular Biology, Penn State, University Park, Pennsylvania, USA.; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA., Gui W; Huck Institutes of the Life Sciences, Penn State, University Park, Pennsylvania, USA., Wolfe TM; Department of Microbiology and Cell Biology, Montana State University, Bozeman, Montana, USA., Koo I; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University (Penn State), University Park, Pennsylvania, USA., Murray IA; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University (Penn State), University Park, Pennsylvania, USA., Nettleford SK; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University (Penn State), University Park, Pennsylvania, USA., Yokoyama S; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University (Penn State), University Park, Pennsylvania, USA., Dong F; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University (Penn State), University Park, Pennsylvania, USA., Koshkin S; Huck Institutes of the Life Sciences, Penn State, University Park, Pennsylvania, USA., Prabhu KS; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University (Penn State), University Park, Pennsylvania, USA., Turnbaugh PJ; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA.; Chan Zuckerberg Biohub-San Francisco, San Francisco, California, USA., Walk ST; Department of Microbiology and Cell Biology, Montana State University, Bozeman, Montana, USA., Perdew GH; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University (Penn State), University Park, Pennsylvania, USA., Patterson AD; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University (Penn State), University Park, Pennsylvania, USA.

Publikováno v: Environmental health perspectives [Environ Health Perspect] 2024 Aug; Vol. 132 (8), pp. 87005. Date of Electronic Publication: 2024 Aug 14.

Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids.

Autor: Zhu B; Department of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA., Zhu X; Department of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA., Borland MG; Department of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Biochemistry, Microbiology and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA., Ralph DH; Department of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA., Chiaro CR; Department of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Genetics, The Pennsylvania State University, University Park, PA 16802, USA., Krausz KW; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Ntambi JM; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA., Glick AB; Department of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA., Patterson AD; Department of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA., Perdew GH; Department of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Biochemistry, Microbiology and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Genetics, The Pennsylvania State University, University Park, PA 16802, USA., Gonzalez FJ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Peters JM; Department of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Biochemistry, Microbiology and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Genetics, The Pennsylvania State University, University Park, PA 16802, USA.

Publikováno v: Biomolecules [Biomolecules] 2024 May 21; Vol. 14 (6). Date of Electronic Publication: 2024 May 21.