S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

Autor: Amado Carreras-Sureda, Laurence Abrami, Kim Ji-Hee, Wen-An Wang, Christopher Henry, Maud Frieden, Monica Didier, F Gisou van der Goot, Nicolas Demaurex

Publikováno v: eLife, Vol. 10 (2021) P. e72051
eLife, Vol 10 (2021)
eLife

Efficient immune responses require Ca2+fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::76a7f81d8fa76357958d61a7e90d787e
https://archive-ouverte.unige.ch/unige:159183

Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene

Autor: John DiGiovanni, Gyu Song, Lars Mecklenburg, Alexsandra Espejo, Richard D. Wood, Jean Louis Guénet, Jean Jaubert, Marcela Del Rio, Donna F. Kusewitt, Claudio J. Conti, Fernando Benavides, Lucía Martínez-Santamaría, Sharon Y.R. Dent, Eleonora Napoli, Cecilia R Giulivi, Carlos J. Perez, Brian M. Iritani, Mark T. Bedford

Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2015, 135 (12), pp.3133-3143. ⟨10.1038/jid.2015.314⟩
The Journal of investigative dermatology
The Journal of investigative dermatology, vol 135, iss 12
Journal of Investigative Dermatology, 2015, 135 (12), pp.3133-3143. ⟨10.1038/jid.2015.314⟩

International audience; Here we describe a spontaneous mutation in the Zdhhc13 (zinc finger, DHHC domain containing 13) gene (also called Hip14l), one of 24 genes encoding palmitoyl acyltransferase (PAT) enzymes in the mouse. This mutation (Zdhhc13lu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c34a12fdbc04c5b36082aba45daae43
https://doi.org/10.1038/jid.2015.314

Constitutive Expression of a Grapevine Stilbene Synthase Gene in Transgenic Hop (Humulus lupulus L.) Yields Resveratrol and Its Derivatives in Substantial Quantities

Autor: Axel Schwekendiek, Arne Heyerick, Gerd Weber, Otmar Spring, Florian Peschke, Denis De Keukeleire, Benjamin Pickel, Nicola T Pitsch

Publikováno v: Journal of Agricultural and Food Chemistry. 55:7002-7009

Resveratrol, a well-known phytoalexin and antioxidant, is produced by the action of stilbene synthase (STS) in some plant species. Hop (Humulus lupulus L.) plants of the Tettnang variety were transformed with a gene encoding for STS from grapevine. U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693c213044818a7dbf6529ecbe70d0c2
https://doi.org/10.1021/jf070509e

In silico predicted mycobacterial epitope elicits in vitro T-cell responses

Autor: Carmen Fernández, Zeba I. Seraj, Mohammad Murshid Alam, Firdausi Qadri, Rajib Chakravorty, Shabnam Zaman, Taufiqur Rahman Bhuiyan, Muhammad Jubayer Rahman, Kawsar Khan, Sajib Chakraborty

Epitope-based vaccines permit the selection of only a specific subset of epitopes to induce the necessary immune response, thus providing a rational alternative to conventional design approaches. Using a range of immunoinformatics tools, we identifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ec25417723543f80825905fc2340d8
https://hdl.handle.net/20.500.14017/134af80c-402d-405d-b119-5b8f81ea6f9d

GLADX: an automated approach to analyze the lineage-specific loss and pseudogenization of genes

Autor: Dainat, Jacques, Paganini, Julien, Pontarotti, Pierre, Gouret, Philippe

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2012, 7 (6), pp.e38792. ⟨10.1371/journal.pone.0038792⟩
PLoS ONE, Vol 7, Iss 6, p e38792 (2012)
PLoS ONE, 2012, 7 (6), pp.e38792. ⟨10.1371/journal.pone.0038792⟩

International audience; A well-established ancestral gene can usually be found, in one or multiple copies, in different descendant species. Sometimes during the course of evolution, all the representatives of a well-established ancestral gene disappe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1ecfe296efdcd14c4b62ed09e2551d02
https://hal.archives-ouvertes.fr/hal-00831091