Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia

Autor: Clément Bodineau, Benjamin Uzan, Sebastian van Liempd, Jean-Max Pasquet, Juan M. Falcón-Pérez, Elodie Muzotte, H. Rezvani, Julien Calvo, Elodie Richard, María L. Toribio, Patricia Fuentes, Isabelle Redonnet-Vernhet, Silvia Terés, Marion Bouchecareilh, Mercedes Tomé, Pierre Soubeyran, Piedad del Socorro Murdoch, Benoit Rousseau, Tra Ly Nguyen, Françoise Pflumio, Marie-Julie Nokin, Oriane Galmar, Raúl V. Durán, Abdel-Majid Khatib, Muriel Priault

Publikováno v: Molecular Oncology
Molecular Oncology, Elsevier, 2021, 15 (5), pp.1412-1431. ⟨10.1002/1878-0261.12877⟩
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Molecular Oncology, Elsevier, 2021, 15, pp.1412-1431. ⟨10.1002/1878-0261.12877⟩
Digital.CSIC. Repositorio Institucional del CSIC
Molecular Oncology, Vol 15, Iss 5, Pp 1412-1431 (2021)

During glutamine sufficiency, both Notch‐positive and Notch‐negative T‐ALL cells promote glutamine catabolism, leading to mammalian target of rapamycin complex 1 (mTORC1) activation and cell growth and proliferation. However, during glutamine s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274dd93100a7d24ada66a7c0aca2aad0
https://hal-cnrs.archives-ouvertes.fr/hal-03401225