Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Acute radiation exposure"'
Autor:
Guru Prasad Sharma, Heather A. Himburg
Publikováno v:
Toxics, Vol 10, Iss 12, p 747 (2022)
As the single cell lining of the heart and all blood vessels, the vascular endothelium serves a critical role in maintaining homeostasis via control of vascular tone, immune cell recruitment, and macromolecular transit. For victims of acute high-dose
Externí odkaz:
https://doaj.org/article/a4dc24d4ce17484584c5146977360f6e
Autor:
Tracy Gasperetti, Tessa Miller, Feng Gao, Jayashree Narayanan, Elizabeth R. Jacobs, Aniko Szabo, George N. Cox, Christie M. Orschell, Brian L. Fish, Meetha Medhora
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/26b5745512674cf68571a00d4e5420e0
Autor:
Vijay K. Singh, Thomas M Seed
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The increasing risks of radiological or nuclear attacks or associated accidents have served to renew interest in developing radiation medical countermeasures. The development of prospective countermeasures and the subsequent gain of Food and Drug Adm
Externí odkaz:
https://doaj.org/article/a79573121b314955a119e92e2038522d
Autor:
Tracy Gasperetti, Tessa Miller, Feng Gao, Jayashree Narayanan, Elizabeth R. Jacobs, Aniko Szabo, George N. Cox, Christie M. Orschell, Brian L. Fish, Meetha Medhora
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
There is a need for countermeasures to mitigate lethal acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE). In WAG/RijCmcr rats, ARS occurs by 30-days following total body irradiation (TBI), and manifests as potenti
Externí odkaz:
https://doaj.org/article/aee906c9674c4646bea3f7da8a6a1a72
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Cognitive dysfunction following radiation treatment for brain cancers in both children and adults have been correlated to impairment of neurogenesis in the hippocampal dentate gyrus. Various species and strains of rodent models have been used to stud
Externí odkaz:
https://doaj.org/article/b5a34bcd0f954ebf85f068f6bd927a1b
Autor:
Lisa S Carnell, Kasandra S Hunter, Mary J. Homer, Corey M Hoffman, Andrea L. DiCarlo, Shannon G Loelius
Publikováno v:
International journal of radiation biology
Ionizing radiation can cause devastating injuries including hemorrhage, immune suppression, increased susceptibility to infection, and death. Medical countermeasures (MCMs) that address and mitigate radiation-induced injuries are the most important t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdeed5cfe8af1e929c76b46a47f99204
https://doi.org/10.1080/09553002.2021.2002661
https://doi.org/10.1080/09553002.2021.2002661
Autor:
Thomas J. MacVittie, Ann M. Farese
Publikováno v:
Journal of radiological protection : official journal of the Society for Radiological Protection. 41(4)
Recent advances in medical countermeasures (MCMs) has been dependent on the Food and Drug Administration (FDA) animal rule (AR) and the final guidance document provided for industry on product development. The criteria outlined therein establish the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cd9ba07b64c6af3c972727e15d662d
https://pubmed.ncbi.nlm.nih.gov/34433144
https://pubmed.ncbi.nlm.nih.gov/34433144
Autor:
Hailin Feng, P. Artur Plett, Hui Lin Chua, Catherine Booth, Gregory Tudor, Carol H. Sampson, Alexa Fisher, Rajendran Sellamuthu, Andrea M. Patterson, Thomas J. MacVittie, Barry P. Katz, Christie M. Orschell, Steven J. Miller, Sasidhar Vemula
Publikováno v:
Radiation research. 195(4)
Medical countermeasures (MCMs) for hematopoietic acute radiation syndrome (H-ARS) should be evaluated in well-characterized animal models, with consideration of at-risk populations such as pediatrics. We have developed pediatric mouse models of H-ARS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d00d0458a938c09909646cac501b46
https://pubmed.ncbi.nlm.nih.gov/33577641
https://pubmed.ncbi.nlm.nih.gov/33577641
Publikováno v:
Journal of proteome research. 20(1)
Rapid early triage and dose estimation is vital for limited medical resource allocation and treatment of a large number of the wounded after radiological accidents. Lipidomics has been utilized to delineate biofluid lipid signatures after irradiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ed9dc149778ddbb0c5cbfccf3c0eed
https://pubmed.ncbi.nlm.nih.gov/33200940
https://pubmed.ncbi.nlm.nih.gov/33200940
Publikováno v:
Health Phys
Inflammation is commonly cited as a mechanism of delayed effects of acute radiation exposure (DEARE). Confirmation of its presence could provide significant insight to targeted use of treatments or mitigators of DEARE. We sought to quantify the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4601af20235f61e4a846f9bbb5f7143
https://pubmed.ncbi.nlm.nih.gov/32941291
https://pubmed.ncbi.nlm.nih.gov/32941291