Zobrazeno 1 - 10
of 931
pro vyhledávání: '"Activity-based protein profiling"'
Autor:
Kyoung-Min Choi, Sung-Jin Kim, Mi-Jung Ji, Eunjung Kim, Jae-Sung Kim, Hyun‑Mee Park, Jae-Young Kim
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Gastric cancer (GC) is a prevalent malignancy with limited therapeutic options for advanced stages. This study aimed to identify novel therapeutic targets for GC by profiling HSP90 client kinases. Methods We used mass spectrometry
Externí odkaz:
https://doaj.org/article/024fce16fd1b4a2ca66a91eb5b776b70
Autor:
Sabrina Ninck, Thomas Klaus, Tatiana V. Kochetkova, Sarah P. Esser, Leonard Sewald, Farnusch Kaschani, Christopher Bräsen, Alexander J. Probst, Ilya V. Kublanov, Bettina Siebers, Markus Kaiser
Publikováno v:
Environmental Microbiome, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Background Microbial communities are important drivers of global biogeochemical cycles, xenobiotic detoxification, as well as organic matter decomposition. Their major metabolic role in ecosystem functioning is ensured by a unique set of enz
Externí odkaz:
https://doaj.org/article/32d68e215869443bb788502c1b606ca7
Autor:
Conor J. R. Scott, Nicholas G. S. McGregor, Daniel R. Leadbeater, Nicola C. Oates, Janina Hoßbach, Amira Abood, Alexander Setchfield, Adam Dowle, Herman S. Overkleeft, Gideon J. Davies, Neil C. Bruce
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 7 (2024)
ABSTRACT Parascedosporium putredinis NO1 is a plant biomass-degrading ascomycete with a propensity to target the most recalcitrant components of lignocellulose. Here we applied proteomics and activity-based protein profiling (ABPP) to investigate the
Externí odkaz:
https://doaj.org/article/5af28a9d52c443db935cb81de8b8bc98
Autor:
Karoline Jerye, Helko Lüken, Anika Steffen, Christian Schlawis, Lothar Jänsch, Stefan Schulz, Mark Brönstrup
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract The salinilactones, volatile marine natural products secreted from Salinispora arenicola, feature a unique [3.1.0]‐lactone ring system and cytotoxic activities through a hitherto unknown mechanism. To find their molecular target, an activi
Externí odkaz:
https://doaj.org/article/7852dd7d099c4aa68364a3d33d98d9bc
Autor:
Qiuyan Guo, Minghong Zhao, Qixin Wang, Tianming Lu, Piao Luo, Lin Chen, Fei Xia, Huanhuan Pang, Shengnan Shen, Guangqing Cheng, Chuanhao Dai, Yuqing Meng, Tianyu Zhong, Chong Qiu, Jigang Wang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116304- (2024)
Glycyrrhetinic acid (GA) shows great efficiency against non-small cell lung cancer (NSCLC), but the detailed mechanism is unclear, which has limited its clinical application. Herein, we investigated the potential targets of GA against NSCLC by activi
Externí odkaz:
https://doaj.org/article/f2973d33c9374da3990d3140034f8555
Autor:
Exequiel Oscar Jesus Porta
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 13, Iss 4, Pp 639-645 (2023)
Activity-based protein profiling (ABPP) is a chemoproteomic approach that employs small-molecule probes to directly evaluate protein functionality within complex proteomes. This technology has proven to be a potent strategy for mapping ligandable sit
Externí odkaz:
https://doaj.org/article/78af3f462d224019a391f2ef6e686283
Autor:
Fan Wen, Dandan Liu, Mingming Wang, Shujie Zhang, Wenhua Kuang, Lixia Yuan, Jigang Wang, Gang Liu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115815- (2023)
Celastrol, a natural compound purified from the Chinese herb Tripterygium wilfordii Hook. f., has excellent pharmacological activity for the treatment of various diseases. Assessing the safety of its use is essential for its development into a clinic
Externí odkaz:
https://doaj.org/article/9b8a174fc6dd44a7b75813f1f4c8761d
Autor:
Jin Zhang, Cong Lin, Sha Jin, Hongshuang Wang, Yibo Wang, Xiubo Du, Mark R. Hutchinson, Huiying Zhao, Le Fang, Xiaohui Wang
Publikováno v:
Exploration, Vol 3, Iss 5, Pp n/a-n/a (2023)
Abstract In recent years, cannabidiol (CBD), a non‐psychotropic cannabinoid, has garnered substantial interest in drug development due to its broad pharmacological activity and multi‐target effects. Diabetes is a chronic metabolic disease that ca
Externí odkaz:
https://doaj.org/article/c2ffb01d93ab4682b070c966a5a7deb4
Autor:
Jinlian Wei, Xin Chen, Yongyun Li, Ruoxi Li, Keting Bao, Liang Liao, Yuqing Xie, Tiannuo Yang, Jin Zhu, Fei Mao, Shuaishuai Ni, Renbing Jia, Xiaofang Xu, Jian Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 10, Pp 3861-3876 (2022)
Conjunctival melanoma (CM) is a rare and fatal malignant eye tumor. In this study, we deciphered a novel anti-CM mechanism of a natural tetracyclic compound named as cucurbitacin B (CuB). We found that CuB remarkably inhibited the proliferation of CM
Externí odkaz:
https://doaj.org/article/bbf1edaf122846d9b791c822994c68ca
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