Different Immunoregulation Roles of Activin A Compared With TGF-β

Autor: Fanglin Li, Yiru Long, Xiaolu Yu, Yongliang Tong, Likun Gong

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin

Externí odkaz: https://doaj.org/article/167e9c0e036048e8a6115d0e3eb44fda

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A follistatin-based molecule increases muscle and bone mass without affecting the red blood cell count in mice

Autor: Johannes P.T.M. van Leeuwen, Marco Eijken, Bram C. J. van der Eerden, Andreas Lodberg, Bianca Boers-Sijmons, Annemarie Brüel, Jesper Skovhus Thomsen

Publikováno v: FASEB Journal, 33(5), 6001-6010. FASEB
Lodberg, A, van der Eerden, B C J, Boers-Sijmons, B, Thomsen, J S, Brüel, A, van Leeuwen, J P T M & Eijken, M 2019, ' A follistatin-based molecule increases muscle and bone mass without affecting the red blood cell count in mice ', F A S E B Journal, vol. 33, no. 5, pp. 6001-6010 . https://doi.org/10.1096/fj.201801969RR

Inhibitors of the activin receptor signaling pathway (IASPs) have become candidate therapeutics for sarcopenia and bone remodeling disorders because of their ability to increase muscle and bone mass. However, IASPs utilizing activin type IIA and IIB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16136aa34fbbebe2b6300d2d8554d4b1
https://doi.org/10.1096/fj.201801969RR

Activin type IIA decoy receptor and intermittent parathyroid hormone in combination overturns the bone loss in disuse-osteopenic mice

Autor: Frederik Duch Bromer, Marco Eijken, Bram C. J. van der Eerden, Jesper Skovhus Thomsen, Andreas Lodberg, Mikkel Bo Brent, Annemarie Brüel

Publikováno v: Brent, M B, Lodberg, A, Bromer, F D, van der Eerden, B C J, Eijken, M, Brüel, A & Thomsen, J S 2021, ' Activin type IIA decoy receptor and intermittent parathyroid hormone in combination overturns the bone loss in disuse-osteopenic mice ', Bone, vol. 142, 115692 . https://doi.org/10.1016/j.bone.2020.115692
Bone, 142:115692. Elsevier Inc.

Damage of the lower motor neuron cell bodies or their axons results in reduced or abolished voluntary movement accompanied by a substantial loss of bone and muscle mass. Intermittent parathyroid hormone 1–34 (PTH) (teriparatide) is one of the most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb67fc0ac2b3af200271ff67cd7d402
https://pubmed.ncbi.nlm.nih.gov/33069923

Role of dipeptidyl peptidase-4 as a potentiator of activin/nodal signaling pathway

Autor: Minjoo Jang, Dong-Seok Park, Sun-Cheol Choi, Kyuhee Kim

Publikováno v: BMB Reports

DPP4 (dipeptidyl peptidase-4), a highly conserved transmembrane glycoprotein with an exo-peptidase activity, has been shown to contribute to glucose metabolism, immune regulation, signal transduction, and cell differentiation. Here, we show that DPP4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc1cc839c2d2c39d5894a0a4d625af1
https://pubmed.ncbi.nlm.nih.gov/30463640