The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export

Autor: Vohhodina, Jekaterina, Barros, Eliana M, Savage, Abigail L, Liberante, Fabio G, Manti, Lorenzo, Bankhead, Peter, Cosgrove, Nicola, Madden, Angelina F, Harkin, D Paul, Savage, Kienan I

Publikováno v: Nucleic Acids Research
Vohhodina, J, Barros, E M, Savage, A L, Liberante, F G, Manti, L, Bankhead, P, Cosgrove, N, Madden, A F, Harkin, D P & Savage, K I 2017, ' The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export ', Nucleic Acids Research, vol. 45, no. 22, gkx1046, pp. 1-18 . https://doi.org/10.1093/nar/gkx1046
Vohhodina, J, Barros, E M, Savage, A L, Liberante, F G, Manti, L, Bankhead, P, Cosgrove, N, Madden, A F, Harkin, D P & Savage, K I 2017, ' The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export ', Nucleic Acids Research, vol. 45, no. 22, pp. 12816-12833 . https://doi.org/10.1093/nar/gkx1046

mRNA splicing and export plays a key role in the regulation of gene expression, with recent evidence suggesting an additional layer of regulation of gene expression and cellular function through the selective splicing and export of genes within speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::45deb37bf3e0941a7b3e64b9fc62240e
http://livrepository.liverpool.ac.uk/3044540/1/gkx1046.pdf

ADP-ribose polymer depletion leads to nuclear Ctcf re-localization and chromatin rearrangement

Autor: Tiziana Guastafierro, Anna Reale, Oliviano Martella, Angela Catizone, Margherita Miccheli, Dawn Farrar, Fabio Ciccarone, Maria Di Girolamo, Michele Zampieri, Roberta Calabrese, Maria Giulia Bacalini, Paola Caiafa, Elena Klenova

Publikováno v: Biochemical Journal. 449:623-630

Ctcf (CCCTC-binding factor) directly induces Parp [poly(ADPribose) polymerase] 1 activity and its PARylation [poly(ADPribosyl) ation] in the absence of DNA damage. Ctcf, in turn, is a substrate for this post-synthetic modification and as such it is c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fb1efc6f36b21b420bb75a6f94c44a
https://doi.org/10.1042/bj20121429

HCFC1 loss-of-function mutations disrupt neuronal and neural progenitor cells of the developing brain

Autor: Lachlan A. Jolly, Lam Son Nguyen, Pavlína Plevová, Claudio Graziano, Zdenek Sedlacek, Jozef Gecz, Vera M. Kalscheuer, Simon C. Barry, Miroslava Hancarova, Elena Bonora, Ying Sun, Marketa Havlovicova, Deepti Domingo, Tommaso Pippucci, Marketa Vlckova

Publikováno v: Europe PubMed Central
Human Molecular Genetics

Both gain- and loss-of-function mutations have recently implicated HCFC1 in neurodevelopmental disorders. Here, we extend our previous HCFC1 over-expression studies by employing short hairpin RNA to reduce the expression of Hcfc1 in embryonic neural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02987c64e29761721c7df6a2d7fdbf01
https://pubmed.ncbi.nlm.nih.gov/25740848

Tuning the transport properties of HIV-1 tat arginine-rich motif in living cells

Autor: Michela Serresi, Fabio Beltram, Ranieri Bizzarri, Francesco Cardarelli

Publikováno v: Traffic (Copenhagen. Print) 9 (2008): 528–539. doi:10.1111/j.1600-0854.2007.00696.x
info:cnr-pdr/source/autori:Cardarelli, F; Serresi, M; Bizzarri, R; Beltram, F/titolo:Tuning the transport properties of HIV-1 tat arginine-rich motif in living cells/doi:10.1111%2Fj.1600-0854.2007.00696.x/rivista:Traffic (Copenhagen. Print)/anno:2008/pagina_da:528/pagina_a:539/intervallo_pagine:528–539/volume:9

A large body of work is currently devoted to the rational design of new molecular carriers for the controlled delivery of cargoes (e.g. proteins or nucleic acids) to relevant subcellular domains, particularly the nucleus. In this article, we show tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd077f5bbb49c4b8888a6794493efcf8
http://hdl.handle.net/11568/991269

Subcellular localization of the cyclin dependent kinase inhibitor Sic1 is modulated by the carbon source in budding yeast

Autor: Lilia Alberghina, Riccardo L. Rossi, Zinzalla, Marco Vanoni, Mastriani A

The cyclin dependent kinase inhibitor Sic1 and the cyclin Clb5 are essential regulators of the cyclin dependent kinase Cdc28 during the G1 to S transition in budding yeast. Yeast enters S phase after ubiquitin-mediated degradation of Sic1, an event t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93004e55f371e69921d85ed3127df990
http://hdl.handle.net/10281/15399