Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

Autor: Amit Kumar, Oscar Vadas, Nicolas Dos Santos Pacheco, Xu Zhang, Kin Chao, Nicolas Darvill, Helena Ø Rasmussen, Yingqi Xu, Gloria Meng-Hsuan Lin, Fisentzos A Stylianou, Jan Skov Pedersen, Sarah L Rouse, Marc L Morgan, Dominique Soldati-Favre, Stephen Matthews

Publikováno v: Kumar, A, Vadas, O, Dos Santos Pacheco, N, Zhang, X, Chao, K, Darvill, N, Rasmussen, H Ø, Xu, Y, Lin, G M-H, Stylianou, F A, Pedersen, J S, Rouse, S L, Morgan, M L, Soldati-Favre, D & Matthews, S 2023, ' Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii ', eLife, vol. 12 . https://doi.org/10.7554/eLife.86049

The phylum of Apicomplexa groups intracellular parasites that employ substrate-dependent gliding motility to invade host cells, egress from the infected cells, and cross biological barriers. The glideosome-associated connector (GAC) is a conserved pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bcdeb04e5a4e623d5f3af8c20553026
https://pure.au.dk/portal/da/publications/structural-and-regulatory-insights-into-the-glideosomeassociated-connector-from-toxoplasma-gondii(882484a3-51a4-4027-b7cc-e5abd3338998).html

Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells

Autor: Karim Bouzakri, Katharina Rickenbach, Caroline Arous, Michel Pinget, Bernhard Wehrle-Haller, Maria L. Mizgier

Publikováno v: Journal of Biological Chemistry, Vol. 295, No 49 (2020) pp. 16510-16528
The Journal of Biological Chemistry

Elevated levels of fasting insulin release and insufficient glucose-stimulated insulin secretion (GSIS) are hallmarks of diabetes. Studies have established cross-talk between integrin signaling and insulin activity, but more details of how integrin-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4063a6b9e04781fc7fe5d6ec0c61ec14
https://doi.org/10.1074/jbc.ra120.012957

Condensation of the fusion focus by the intrinsically disordered region of the formin Fus1 is essential for cell-cell fusion

Autor: Ingrid Billault-Chaumartin, Olivia Muriel, Laetitia Michon, Sophie G Martin

Publikováno v: Current biology, vol. 32, no. 21, pp. 4752-4761.e10
bioRxiv
BioRxiv

Secretory vesicle clusters transported on actin filaments by myosin V motors for local secretion underlie various cellular processes, such as neurotransmitter release at neuronal synapses, 1 hyphal steering in filamentous fungi, 2 , 3 and local cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd0d1bbe7438bd479da8553c613d8c7
https://doi.org/10.1101/2022.05.05.490810

The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

Autor: John Blaikley, Gareth B. Kitchen, Tracy Hussell, Mudassar Iqbal, Robert Maidstone, Laura Matthews, Hannah J. Durrington, Peter S. Cunningham, James Bagnall, Nicola Begley, Matthew Baxter, Ben Saer, Toryn Poolman, Julie E. Gibbs, Andrew S. I. Loudon, David W. Ray, David H. Dockrell

Publikováno v: Kitchen, G B, Cunningham, P S, Poolman, T M, Iqbal, M, Maidstone, R, Baxter, M, Bagnall, J, Begley, N, Saer, B, Hussell, T, Matthews, L C, Dockrell, D H, Durrington, H J, Gibbs, J E, Blaikley, J F, Loudon, A S & Ray, D W 2020, ' The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia ', Proceedings of the National Academy of Sciences, vol. 117, no. 3, pp. 1543-1551 . https://doi.org/10.1073/pnas.1915932117

The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2f3ec07d41a024bb148b8e2b4eb0d7
https://doi.org/10.1073/pnas.1915932117

SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering

Autor: Ka Wan Li, Fatima Farzana, Frank Koopmans, August B. Smit, Jessie W. Brunner, Silvia Oldani, Matthijs Verhage, Marinka Brouwer, Ruud F. Toonen, Ning Chen, Jan R.T. van Weering

Publikováno v: Brouwer, M, Farzana, F, Koopmans, F, Chen, N, Brunner, J W, Oldani, S, Li, K W, van Weering, J R T, Smit, A B, Toonen, R F & Verhage, M 2019, ' SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering ', EMBO Journal, vol. 38, no. 17, e101289 . https://doi.org/10.15252/embj.2018101289
EMBO Journal, 38(17):e101289, 1-20. Nature Publishing Group
EMBO Journal, 38(17):e101289. Wiley-Blackwell
Brouwer, M, Farzana, F, Koopmans, F, Chen, N, Brunner, J W, Oldani, S, Li, K W, van Weering, J R, Smit, A B, Toonen, R F & Verhage, M 2019, ' SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering ', EMBO Journal, vol. 38, no. 17, e101289, pp. 1-20 . https://doi.org/10.15252/embj.2018101289
The EMBO Journal

Synapse development requires spatiotemporally regulated recruitment of synaptic proteins. In this study, we describe a novel presynaptic mechanism of cis‐regulated oligomerization of adhesion molecules that controls synaptogenesis. We identified sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccd74ba8c64f4a684dea731fcb80231
https://doi.org/10.15252/embj.2018101289