Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Acong Yang"'
Autor:
Xavier Bofill-De Ros, Zhenyi Hong, Ben Birkenfeld, Sarangelica Alamo-Ortiz, Acong Yang, Lisheng Dai, Shuo Gu
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 279-289 (2022)
The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we per
Externí odkaz:
https://doaj.org/article/323a20767c8b455ebfa77ffc7863939f
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors reveal insights into miRNA tailing specificity of TENTs and their effect on miRNA levels by combinatory KOs of TENT2, TUT4 and TUT7. They show uridylation is linked to TENT2 and identify non-redundant functions between TUT4 and TUT7.
Externí odkaz:
https://doaj.org/article/c66fdbe2ae7040d2a5ca5f3ebad26dc5
Autor:
Seungjae Lee, David Jee, Sid Srivastava, Acong Yang, Abhinav Ramidi, Renfu Shang, Diane Bortolamiol-Becet, Sébastien Pfeffer, Shuo Gu, Jiayu Wen, Eric C. Lai
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112111- (2023)
Summary: Canonical microRNA (miRNA) hairpins are processed by the RNase III enzymes Drosha and Dicer into ∼22 nt RNAs loaded into an Argonaute (Ago) effector. In addition, splicing generates numerous intronic hairpins that bypass Drosha (mirtrons)
Externí odkaz:
https://doaj.org/article/e5a6e87b637141948837c14c388a3164
Autor:
Acong Yang, Tie-Juan Shao, Xavier Bofill-De Ros, Chuanjiang Lian, Patricia Villanueva, Lisheng Dai, Shuo Gu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
3′ end of microRNAs binds to the PAZ domain of Argonaute (AGO) proteins. Here the authors show that terminal nucleotidyltransferases TUT4/7 and exonuclease DIS3L2 induce tailing and decay of 3’ end exposed-microRNAs in AGO PAZ mutant expressing-
Externí odkaz:
https://doaj.org/article/cf79b8e7987b4e57af1d8a30458a8f70
Autor:
Xavier Bofill-De Ros, Wojciech K. Kasprzak, Yuba Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tie-Juan Shao, Bruce A. Shapiro, Yun-Xing Wang, Shuo Gu
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 447-459.e4 (2019)
Summary: MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity. To understand how pri-miRNA sequence and structure influence Drosha cleavage, we studie
Externí odkaz:
https://doaj.org/article/ddfe0f6fd3994ce482d993e45c7ea9a6
Autor:
Acong Yang, Shuo Gu, Bao Tran, Xavier Bofill-De Ros, Lisheng Dai, Sean Chen, Chuanjiang Lian, Tony Shi, Lillian Hallmark, Yongmei Zhao, Howard Crouch
Publikováno v:
RNA Biol
MicroRNAs (miRNAs) are a class of small noncoding RNAs about 22-nucleotide (nt) in length that collectively regulate more than 60% of coding genes. Aberrant miRNA expression is associated with numerous diseases, including cancer. miRNA biogenesis is
Autor:
Chuanjiang Lian, Patricia Villanueva, Shuo Gu, Xavier Bofill-De Ros, Tie-Juan Shao, Acong Yang, Lisheng Dai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
MicroRNAs (miRNAs) associated with Argonaute proteins (AGOs) regulate gene expression in mammals. miRNA 3’ ends are subject to frequent sequence modifications, which have been proposed to affect miRNA stability. However, the underlying mechanism is
Autor:
Kellie D. Nance, Supuni Thallala Gamage, Md Masud Alam, Acong Yang, Michaella J. Levy, Courtney Link, Laurence Florens, Michael P. Washburn, Shuo Gu, Joost J. Oppenheim, Jordan Meier
Publikováno v:
SSRN Electronic Journal.
Autor:
Shuo Gu, Kellie D. Nance, Jordan L. Meier, Joost J. Oppenheim, Michael P. Washburn, Courtney N. Link, Acong Yang, Supuni Thalalla Gamage, Laurence Florens, Masud Alam, Michaella J. Levy
Publikováno v:
Cell Chemical Biology. 29:312-320.e7
Summary Synthetic messenger RNA (mRNA) is an emerging therapeutic platform with important applications in oncology and infectious disease. Effective mRNA medicines must be translated by the ribosome but not trigger a strong nucleic acid-mediated immu
Autor:
Ferri Soheilian, Velayoudame Parthibane, Lino Tessarollo, Kunio Nagashima, Stephen D. Fox, Jonathan R. Keller, Usha Acharya, Diwash Acharya, Jairaj K. Acharya, Thiruvaimozhi Abimannan, Thorkell Andresson, Jing Lin, Sargur Madabushi Srideshikan, Acong Yang, Kimberly D. Klarmann
Publikováno v:
The Journal of Biological Chemistry
Serine palmitoyltransferase complex (SPT) mediates the first and rate-limiting step in the de novo sphingolipid biosynthetic pathway. The larger subunits SPTLC1 and SPTLC2/SPTLC3 together form the catalytic core while a smaller third subunit either S