Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities.

Autor: Vohidov F; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Andersen JN; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Economides KD; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Shipitsin MV; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Burenkova O; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Ackley JC; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Vangamudi B; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Nguyen HV; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Gallagher NM; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Shieh P; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Golder MR; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Liu J; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Dahlberg WK; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Ehrlich DJC; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Kim J; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Kristufek SL; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Huh SJ; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Neenan AM; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Baddour J; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Paramasivan S; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., de Stanchina E; Memorial Sloan Kettering Cancer Center, 417 E 68th St, New York, New York 10065, United States., Kc G; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Turnquist DJ; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Saucier-Sawyer JK; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Kopesky PW; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Brady SW; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Jessel MJ; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Reiter LA; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Chickering DE; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Johnson JA; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Blume-Jensen P; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2021 Mar 31; Vol. 143 (12), pp. 4714-4724. Date of Electronic Publication: 2021 Mar 19.

Publisher Correction: Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs.

Autor: Golder MR; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Liu J; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; XTuit Pharmaceuticals, Waltham, MA, USA., Andersen JN; XTuit Pharmaceuticals, Waltham, MA, USA., Shipitsin MV; XTuit Pharmaceuticals, Waltham, MA, USA., Vohidov F; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Nguyen HV; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Ehrlich DC; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Huh SJ; XTuit Pharmaceuticals, Waltham, MA, USA., Vangamudi B; XTuit Pharmaceuticals, Waltham, MA, USA., Economides KD; XTuit Pharmaceuticals, Waltham, MA, USA., Neenan AM; XTuit Pharmaceuticals, Waltham, MA, USA., Ackley JC; XTuit Pharmaceuticals, Waltham, MA, USA., Baddour J; XTuit Pharmaceuticals, Waltham, MA, USA., Paramasivan S; XTuit Pharmaceuticals, Waltham, MA, USA., Brady SW; XTuit Pharmaceuticals, Waltham, MA, USA., Held EJ; XTuit Pharmaceuticals, Waltham, MA, USA., Reiter LA; XTuit Pharmaceuticals, Waltham, MA, USA., Saucier-Sawyer JK; XTuit Pharmaceuticals, Waltham, MA, USA., Kopesky PW; XTuit Pharmaceuticals, Waltham, MA, USA., Chickering DE; XTuit Pharmaceuticals, Waltham, MA, USA., Blume-Jensen P; XTuit Pharmaceuticals, Waltham, MA, USA. pblumejensen@xtuit.com.; Acrivon Therapeutics, Lab Central, Cambridge, MA, USA. pblumejensen@xtuit.com., Johnson JA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. jaj2109@mit.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2018 Sep; Vol. 2 (9), pp. 707.