Lisinopril increases lung ACE2 levels and SARS-CoV-2 viral load and decreases inflammation but not disease severity in experimental COVID-19.

Autor: Silva-Santos Y; Laboratory of Malaria Cellular and Molecular Immunopathology, Faculty of Pharmaceutical Sciences, Department of Clinical and Toxicological Analysis, University of São Paulo, São Paulo, Brazil.; Laboratory of Malaria Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Pagni RL; Immunology Laboratory, Heart Institute, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Gamon THM; Laboratory of Clinical and Molecular Virology, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo, Brazil., de Azevedo MSP; Laboratory of Clinical and Molecular Virology, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo, Brazil.; Laboratory of Experimental Immunoparasitology, Institute of Biomedical Sciences, Department of Parasitology, University of São Paulo, São Paulo, Brazil., Bielavsky M; Laboratory of Malaria Cellular and Molecular Immunopathology, Faculty of Pharmaceutical Sciences, Department of Clinical and Toxicological Analysis, University of São Paulo, São Paulo, Brazil., Darido MLG; Laboratory of Clinical and Molecular Virology, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo, Brazil., de Oliveira DBL; Laboratory of Clinical and Molecular Virology, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo, Brazil.; Hospital Israelita Albert Einstein, São Paulo, Brazil., de Souza EE; Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Wrenger C; Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Durigon EL; Laboratory of Clinical and Molecular Virology, Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo, Brazil., Luvizotto MCR; School of Veterinary Medicine of Araçatuba, São Paulo State University, São Paulo, Brazil., Ackerman HC; Physiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, MD, United States., Marinho CRF; Laboratory of Experimental Immunoparasitology, Institute of Biomedical Sciences, Department of Parasitology, University of São Paulo, São Paulo, Brazil., Epiphanio S; Laboratory of Malaria Cellular and Molecular Immunopathology, Faculty of Pharmaceutical Sciences, Department of Clinical and Toxicological Analysis, University of São Paulo, São Paulo, Brazil., Carvalho LJM; Laboratory of Malaria Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Jul 12; Vol. 15, pp. 1414406. Date of Electronic Publication: 2024 Jul 12 (Print Publication: 2024).

Association of alpha globin gene copy number with exhaled nitric oxide in a cross-sectional study of healthy Black adults.

Autor: Ruhl AP; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA parker.ruhl@nih.gov.; Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Jackson JM; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Carhuas CJ; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Niño de Rivera JG; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Fay MP; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Weinberg JB; Department of Medicine and Division of Hematology, Duke University School of Medicine and Durham VA Medical Centers, Durham, North Carolina, USA., Que LG; Department of Medicine and Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine and Durham VA Medical Centers, Durham, North Carolina, USA., Ackerman HC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Publikováno v: BMJ open respiratory research [BMJ Open Respir Res] 2023 Dec 20; Vol. 10 (1). Date of Electronic Publication: 2023 Dec 20.

Alpha globin gene copy number and incident ischemic stroke risk among Black Americans.

Autor: Ruhl AP; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.; Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland., Jeffries N; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland., Yang Y; Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Rockville, Maryland., Brooks SD; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland., Naik RP; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Pecker LH; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Mott BT; Wake Forest University School of Medicine, Winston-Salem, North Carolina., Winkler CA; Basic Research Laboratory, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Armstrong ND; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama., Zakai NA; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont.; Department of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont., Gutierrez OM; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Judd SE; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama., Howard VJ; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Howard G; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama., Cushman M; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont.; Department of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont., Ackerman HC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 May 22. Date of Electronic Publication: 2023 May 22.

Alpha globin gene copy number and hypertension risk among Black Americans.

Autor: Ruhl AP; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.; Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America., Jeffries N; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America., Yang Y; Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Rockville, Maryland, United States of America., Gutierrez OM; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America., Muntner P; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America., Naik RP; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Pecker LH; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Mott BT; University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States of America., Zakai NA; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, United States of America.; Department of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, United States of America., Safford MM; Department of Medicine, Weill Cornell Medicine, New York, New York, United States of America., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado, Denver, Colorado, United States of America., Winkler CA; Basic Research Laboratory, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America., Cushman M; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, United States of America.; Department of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, United States of America., Ackerman HC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

Publikováno v: PloS one [PLoS One] 2022 Jul 14; Vol. 17 (7), pp. e0271031. Date of Electronic Publication: 2022 Jul 14 (Print Publication: 2022).

Alpha Globin Gene Copy Number Is Associated with Prevalent Chronic Kidney Disease and Incident End-Stage Kidney Disease among Black Americans.

Autor: Ruhl AP; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.; Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland., Jeffries N; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland., Yang Y; Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Rockville, Maryland., Naik RP; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Patki A; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama., Pecker LH; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Mott BT; University of Alabama at Birmingham School of Medicine, Birmingham, Alabama., Zakai NA; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont.; Department of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont., Winkler CA; Basic Research Program, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Kopp JB; Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado, Denver, Colorado., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, Alabama., Gutierrez OM; Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, Alabama.; Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama., Cushman M; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont.; Department of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont., Ackerman HC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2022 Jan; Vol. 33 (1), pp. 213-224. Date of Electronic Publication: 2021 Oct 27.