Disruption of IRE1α through its kinase domain attenuates multiple myeloma.

Autor: Harnoss JM; Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080., Le Thomas A; Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080., Shemorry A; Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080., Marsters SA; Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080., Lawrence DA; Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080., Lu M; Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080., Chen YA; Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080., Qing J; Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080., Totpal K; Translational Oncology, Genentech, Inc., South San Francisco, CA 94080., Kan D; Translational Oncology, Genentech, Inc., South San Francisco, CA 94080., Segal E; Translational Oncology, Genentech, Inc., South San Francisco, CA 94080., Merchant M; Translational Oncology, Genentech, Inc., South San Francisco, CA 94080., Reichelt M; Pathology, Genentech, Inc., South San Francisco, CA 94080., Ackerly Wallweber H; Structural Biology, Genentech, Inc., South San Francisco, CA 94080., Wang W; Structural Biology, Genentech, Inc., South San Francisco, CA 94080., Clark K; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA 94080., Kaufman S; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA 94080., Beresini MH; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA 94080., Laing ST; Pathology, Genentech, Inc., South San Francisco, CA 94080., Sandoval W; Microchemistry, Proteomics and Lipidomics, Genentech, Inc., South San Francisco, CA 94080., Lorenzo M; Protein Chemistry, Genentech, Inc., South San Francisco, CA 94080., Wu J; Protein Chemistry, Genentech, Inc., South San Francisco, CA 94080., Ly J; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA 94080., De Bruyn T; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA 94080., Heidersbach A; Molecular Biology, Genentech, Inc., South San Francisco, CA 94080., Haley B; Molecular Biology, Genentech, Inc., South San Francisco, CA 94080., Gogineni A; Biomolecular Imaging, Genentech, Inc., South San Francisco, CA 94080., Weimer RM; Biomolecular Imaging, Genentech, Inc., South San Francisco, CA 94080., Lee D; Safety Assessment, Genentech, Inc., South San Francisco, CA 94080., Braun MG; Discovery Chemistry, Genentech, Inc., South San Francisco, CA 94080., Rudolph J; Discovery Chemistry, Genentech, Inc., South San Francisco, CA 94080., VanWyngarden MJ; Division of Hematology, Department of Medicine, University of Colorado Cancer Center, Aurora, CO 80045., Sherbenou DW; Division of Hematology, Department of Medicine, University of Colorado Cancer Center, Aurora, CO 80045., Gomez-Bougie P; Centre de Recherche en Cancérologie et Immunologie Nantes-Angers, INSERM, CNRS, Université d'Angers, Université de Nantes, BP 70721 Nantes, France.; Service d'Hématologie Clinique, Unité d'Investigation Clinique, Centre Hospitalier Universitaire, BP 70721 Nantes, France., Amiot M; Centre de Recherche en Cancérologie et Immunologie Nantes-Angers, INSERM, CNRS, Université d'Angers, Université de Nantes, BP 70721 Nantes, France.; Service d'Hématologie Clinique, Unité d'Investigation Clinique, Centre Hospitalier Universitaire, BP 70721 Nantes, France., Acosta-Alvear D; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143.; Howard Hughes Medical Institute, University of California, San Francisco, CA 94143., Walter P; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143.; Howard Hughes Medical Institute, University of California, San Francisco, CA 94143., Ashkenazi A; Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080; aa@gene.com.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Aug 13; Vol. 116 (33), pp. 16420-16429. Date of Electronic Publication: 2019 Aug 01.