Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Acinar cell proliferation"'
Autor:
Xiaoxin Cai, Minjie Zhang, Zuguo Liu, Andrew J. Quantock, Changkai Jia, Xin He, Wei Li, Peter S. Reinach, Zhongyang Zhao, Shaopan Wang, Jie Kang, Yixuan Li, Kechun Li, Jinghua Bu
Publikováno v:
The American Journal of Pathology. 190:2387-2402
The lacrimal gland is critical for maintaining the homeostasis of the ocular surface microenvironment through secreting aqueous tears in mammals. Many systemic diseases such as Sjögren syndrome, rheumatoid arthritis, and diabetes can alter the lacri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb128dee80460cd5862a160edcbf7a4f
https://doi.org/10.1016/j.ajpath.2020.09.002
https://doi.org/10.1016/j.ajpath.2020.09.002
Introduction: The word pancreas comes from the Greek word pankreas. Diabetes mellitus and pancreatic cancer are disorders that involve the pancreas. It comprises Endocrine cells, also known as Islets of Langerhans, which release insulin, glucagon, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7afa950ddefd5bab68e8fdef204fd17f
https://doi.org/10.9734/bpi/nvbs/v1/3520f
https://doi.org/10.9734/bpi/nvbs/v1/3520f
Autor:
Andrew P. Hills, Stephen Myers, Sabrina Sonda, Domenico Salvatore, Rolf Graf, Monica Dentice, Theresia Reding, Ermanno Malagola, Rong Chen, Enrica Saponara, Marta Bombardo
Publikováno v:
The Journal of Pathology. 248:217-229
Proliferation of pancreatic acinar cells is a critical process in the pathophysiology of pancreatic diseases, because limited or defective proliferation is associated with organ dysfunction and patient morbidity. In this context, elucidating the sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062f61f1da6eeddadabadc1ba023a276
https://doi.org/10.1002/path.5247
https://doi.org/10.1002/path.5247
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 1, Pp 1-14 (2021)
Cell Death and Disease, Vol 12, Iss 1, Pp 1-14 (2021)
Acute pancreatitis (AP), an acute inflammatory process, can be difficult to diagnose. Activating transcription factor 4 (ATF4) has been reported to participate in the pathogenesis of AP. Additionally, histone deacetylases (HDACs) are shown to be clos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9c3e9899580da3894a5c8335143b30
https://doi.org/10.1038/s41419-020-03296-x
https://doi.org/10.1038/s41419-020-03296-x
Publikováno v:
British Journal of Pharmacology. 175:335-347
Background and Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) are administered to manage pain typically found in patients suffering from pancreatitis. NSAIDs also display anti-proliferative activity against cancer cells, however their effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2c71b6caa8e2e68beeb3989f996db1a
https://doi.org/10.1111/bph.13867
https://doi.org/10.1111/bph.13867
Autor:
Munehiro Yokoyama, Haruki Kume, Hisashi Matsushima, Maki Ogawa, Yuji Hakozaki, Yoko Hirai, Tomoko Masuda, Taro Murata
Publikováno v:
Urology Case Reports, Vol 20, Iss, Pp 67-69 (2018)
Urology Case Reports
Urology Case Reports
We report a case with prostate cancer and gastric neuroendocrine carcinoma. A 72-year old male presented with a gastric lesion 5 months after radical prostatectomy. The lesion was immunohistochemically positive for PSA, alpha-methylacyl-CoA racemase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241f083e4013b55de8650262fc68de01
http://www.sciencedirect.com/science/article/pii/S2214442018301761
http://www.sciencedirect.com/science/article/pii/S2214442018301761
Autor:
Romain Baer, Laia Masvidal-Sanz, Sauyeun Shin, Julie Guillermet-Guibert, Manon Strehaiano, Yoshinori Tsukumo, Corinne Bousquet, Nahum Sonenberg, Ola Larsson, Stéphane Pyronnet, Nicolas Guilbaud, Yvan Martineau, Jean-Sébastien Hoffmann, Théo Goullet de Rugy, Frédéric Marion, David Müller, Christine Jean, Rémi Samain
Publikováno v:
JCI Insight. 4
Pancreatic ductal adenocarcinoma (PDAC) relies on hyperactivated protein synthesis. Consistently, human and mouse PDAC lose expression of the translational repressor and mTOR target 4E-BP1. Using genome-wide polysome profiling, we here explore mRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c19ad875afea3b560aa3a9ce792dbf9
https://doi.org/10.1172/jci.insight.121951
https://doi.org/10.1172/jci.insight.121951
Autor:
Katja Steiger, Bjoern Konukiewitz, Melanie Gerstenlauer, Wilko Weichert, Thomas Wirth, Lap Kwan Chan, Harald J. Maier
Publikováno v:
Gut. 66:1995-2007
Objective Inhibitory κB kinase (IKK)/nuclear factor κB (NF-κB) signalling has been implicated in the pathogenesis of pancreatitis, but its precise function has remained controversial. Here, we analyse the contribution of IKK/NF-κB signalling in e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37484b4b9657c7cb75e7179c832d78a4
https://doi.org/10.1136/gutjnl-2015-311028
https://doi.org/10.1136/gutjnl-2015-311028
Autor:
Anja Zabel, Rolf Graf, Marta Bombardo, Enrica Saponara, Kamile Grabliauskaite, Theresia Reding, Carmen Faso, Gitta Maria Seleznik, Ermanno Malagola, Sabrina Sonda
Publikováno v:
The Journal of Pathology. 238:434-445
Determining signalling pathways that regulate pancreatic regeneration following pancreatitis is critical for implementing therapeutic interventions. In this study we elucidated the molecular mechanisms underlying the effects of transforming growth fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::112d72c24aedb06869f33bd7e09ba42c
https://doi.org/10.1002/path.4666
https://doi.org/10.1002/path.4666
Autor:
Adrian B. Hehl, Kamile Grabliauskaite, Theresia Reding, Rolf Graf, Enrica Saponara, Yinghua Tian, Alberto B. Silva, Elisabeth M. Schraner, Sabrina Sonda, Ermanno Malagola, Gitta Maria Seleznik, Raphael M Buzzi, Marta Bombardo, Anja Zabel
Publikováno v:
The Journal of Pathology. 237:495-507
The exocrine pancreas exhibits a distinctive capacity for tissue regeneration and renewal following injury. This regenerative ability has important implications for a variety of disorders, including pancreatitis and pancreatic cancer, diseases associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::952e26b9f9b0372e0228248534723678
https://doi.org/10.1002/path.4595
https://doi.org/10.1002/path.4595