Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Achyutharao Sidduri"'
Publikováno v:
ACS Medicinal Chemistry Letters. 14:176-182
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b25c3fbd6691c9b41cb7082de3c426b
https://doi.org/10.1021/acsmedchemlett.2c00476
https://doi.org/10.1021/acsmedchemlett.2c00476
Publikováno v:
Synthesis. 46:430-444
Discovery, optimization, and early development of drug candidates are very challenging and require a versatile synthetic chemistry toolbox. Organozinc chemistry is a powerful methodology for carbon–carbon bond formation which tolerates several func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ac7964522441cd0f9870848edb1bd0e
https://doi.org/10.1055/s-0033-1338589
https://doi.org/10.1055/s-0033-1338589
Autor:
Nadine Tare, Gerry Kaplan, Aruna Railkar, Anjula Pamidimukkala, Karl Frank, Gary Cavallo, Duk Soon Choi, Louise Gerber, Louis M. Renzetti, Jianping Lou, Jefferson Wright Tilley, Achyutharao Sidduri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1036-1040
From a series of N-acyl 4-(3-pyridonyl)phenylalanine derivatives of 4, the trifluoromethyl derivative 28 was identified as a potent, dual acting alpha4 integrin antagonist with activity in primate models of allergic asthma. Investigation of a series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08c5a8da0eaac2bf6512608278d3b51
https://doi.org/10.1016/j.bmcl.2012.12.019
https://doi.org/10.1016/j.bmcl.2012.12.019
Autor:
Duk Soon Choi, Louise Gerber, Jianping Lou, Louis M. Renzetti, Karl Frank, Achyutharao Sidduri, Aruna Railkar, Anjula Pamidimukkala, Gary Cavallo, Jefferson Wright Tilley, Nadine Tare
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1026-1031
N-Acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives of type 4 were designed to replace the 2,6-dichlorobenzoylamine portion of compound 1 in order to identify novel compounds with improved potency against α4-integrins. Several derivatives we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b26e172df191cd396f104c96ab6eb0
https://doi.org/10.1016/j.bmcl.2012.12.026
https://doi.org/10.1016/j.bmcl.2012.12.026
Autor:
Yonglin Ren, Ryan Craig Schoenfeld, Adrian J. Fretland, Maria E. Fuentes, Kung-Ching Chang, Yimin Qian, Rachid Hamid, Yun Chen, Achyutharao Sidduri, Matthew Michael Hamilton, Christopher S. Stevenson, Gabriel Stephen Deems, Lin Zhang, Terry Truitt, Dramane Ibrahim Laine, Arjun Narayanan, Ruoqi Peng, David C. Budd, Matthew C. Lucas, Rama K. Kondru, Ruben Alvarez Sanchez
Publikováno v:
Journal of Medicinal Chemistry. 55:7920-7939
Lysophosphatidic acid is a class of bioactive phospholipid that mediates most of its biological effects through LPA receptors, of which six isoforms have been identified. The recent results from LPA1 knockout mice suggested that blocking LPA1 signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2902548479e1e1e040690c9e871f2659
https://doi.org/10.1021/jm301022v
https://doi.org/10.1021/jm301022v
Publikováno v:
Synthetic Communications. 40:3691-3698
The synthesis of various aryl methyl sulfides has been achieved by treatment of nitroarenes with a combination of (methylthio)trimethylsilane and cesium carbonate in dimethylsulfoxide. This reaction gives access to aryl methyl sulfide derivatives in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f149e1b98ad773dd0d208c289183e870
https://doi.org/10.1080/00397910903531664
https://doi.org/10.1080/00397910903531664
Autor:
Ramakanth Sarabu, Jianping Lou, Achyutharao Sidduri, David J Moore, Jagdish Kumar Racha, Joseph Grimsby, Wendy Lea Corbett, Cheryl Spence, Robert Francis Kester, Linda Marcus, Mark T. Dvorozniak, Joseph F. Grippo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5673-5676
The phenylacetamide 1 represents the archtypical glucokinase activator (GKA) in which only the R -isomer is active. In order to probe whether the chiral center could be replaced, we prepared a series of olefins 2 and show in the present work that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72e2baff0f8f67baf0032bba968bb91
https://doi.org/10.1016/j.bmcl.2010.08.029
https://doi.org/10.1016/j.bmcl.2010.08.029
Autor:
Tina Molinaro, Robert Alan Goodnow, Louis M. Renzetti, Alexandra Hicks, Satish Choudhry, Xin Wei, Gesine J. Hermann, Qi Qiao, Anjula Pamidimukkala, A. Robert Catala, Maureen Hargaden, Jian Ping Lou, Nadine Tare, John O’Neil, Ueli Gubler, Karen Pozzani, David J Moore, Jennifer Santiago, Ruben Marcano, Paul Gillespie, Rachid Hamid, Noal Cohen, Hyesun Oh, Lisa C. F. Chao, Laura Singer, Jefferson Wright Tilley, Romyr Dominique, Grazyna Kurylko, Ying L. Li, Radhika Venkat, Achyutharao Sidduri, Matthew Blake Wright, Ann F. Hoffman, Shahid Tannu, Gary Cavallo, Nader Fotouhi, Thomas Egan, Martin Lamb, Jessica D. Ventre, Agnieszka Kowalczyk, D Lavelle, Helena Mancebo
Publikováno v:
Journal of Medicinal Chemistry. 53:3502-3516
The inhibition of LTB(4) binding to and activation of G-protein-coupled receptors BLT1 and BLT2 is the premise of a treatment for several inflammatory diseases. In a lead optimization effort starting with the leukotriene B(4) (LTB(4)) receptor antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f954d2982302b35c7516d54421fb833
https://doi.org/10.1021/jm1001919
https://doi.org/10.1021/jm1001919
Autor:
Jin-Jun Liu, Christophe Michoud, Feng Chi, Yang Wen, Qing Xiang, Nam T. Le, Shaoqing Chen, Nicole Jackson, Jian Ping Lou, Li Chen, Chunlin Zhao, Achyutharao Sidduri, Louis Portland, Lyubomir T. Vassilev, Fred Konzelmann, Yingsi Chen, Christian Tovar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2134-2138
A novel series of quinolinyl-methylene-thiazolinones has been identified as potent and selective cyclin-dependent kinase 1 (CDK1) inhibitors. Their synthesis and structure activity relationships (SAR) are described. Representative compounds from this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab9e1e7142c358c44595074f3b33ef8
https://doi.org/10.1016/j.bmcl.2007.01.081
https://doi.org/10.1016/j.bmcl.2007.01.081
Publikováno v:
Current Topics in Medicinal Chemistry. 4:1509-1523
Starting with a cyclic peptide of moderate potency as a VLA-4 antagonist, highly potent and conformationally defined cyclic peptides were developed incorporating a constrained tyrosine and an achiral Asp-Pro spacer. N-Acyl phenylalanine derivatives w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39b8d6f0d15c3a5c4c23e8500fe3760
https://doi.org/10.2174/1568026043387502
https://doi.org/10.2174/1568026043387502