Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

Autor: Achuthan, Vasudevan, Perreira, Jill M., Sowd, Gregory A., Puray-Chavez, Maritza, McDougall, William M., Paulucci-Holthauzen, Adriana, Wu, Xiaolin, Fadel, Hind J., Poeschla, Eric M., Multani, Asha S., Hughes, Stephen H., Sarafianos, Stefan G., Brass, Abraham L., Engelman, Alan N.

Publikováno v: In Cell Host & Microbe 12 September 2018 24(3):392-404

Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model.

Autor: Loyola, Lorenz¹ (AUTHOR), Achuthan, Vasudevan² (AUTHOR), Gilroy, Kathryn³ (AUTHOR), Borland, Gillian⁴ (AUTHOR), Kilbey, Anna⁴ (AUTHOR), Mackay, Nancy⁴ (AUTHOR), Bell, Margaret⁵ (AUTHOR), Hay, Jodie⁴ (AUTHOR), Aiyer, Sriram¹ (AUTHOR), Fingerman, Dylan¹ (AUTHOR), Villanueva, Rodrigo A.¹ (AUTHOR), Cameron, Ewan⁵ (AUTHOR), Kozak, Christine A.⁶ (AUTHOR), Engelman, Alan N.^2,7 (AUTHOR), Neil, James⁴ (AUTHOR), Roth, Monica J.¹ (AUTHOR) roth@rwjms.rutgers.edu

Publikováno v: PLoS Pathogens. 12/9/2019, Vol. 15 Issue 12, p1-32. 32p.

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HIV Reverse Transcriptase Fidelity And Inhibition Are Modulated By Divalent Cations In A Concentration-Dependent Manner In Vitro

Autor: Achuthan, Vasudevan

Human immunodeficiency virus (HIV) rapidly evolves through generation and selection of mutants that can escape drug therapy. This process is fueled, in part, by the presumably highly error prone polymerase reverse transcriptase (RT). Fidelity of poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c283f011df9f581035abb3a066af983