Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors

Autor: Muliaditan, Tamara, Halim, Leena, Whilding, Lynsey M., Draper, Benjamin, Achkova, Daniela Y., Kausar, Fahima, Glover, Maya, Bechman, Natasha, Arulappu, Appitha, Sanchez, Jenifer, Flaherty, Katie R., Obajdin, Jana, Grigoriadis, Kristiana, Antoine, Pierre, Larcombe-Young, Daniel, Hull, Caroline M., Buus, Richard, Gordon, Peter, Grigoriadis, Anita, Davies, David M., Schurich, Anna, Maher, John

Publikováno v: In Cell Reports Medicine 21 December 2021 2(12)

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields

Autor: Ilieva, Kristina M., Fazekas-Singer, Judit, Achkova, Daniela Y., Dodev, Tihomir S., Mele, Silvia, Crescioli, Silvia, Bax, Heather J., Cheung, Anthony, Karagiannis, Panagiotis, Correa, Isabel, Figini, Mariangela, Marlow, Rebecca, Josephs, Debra H., Beavil, Andrew J., Maher, John, Spicer, James F., Jensen-Jarolim, Erika, Tutt, Andrew N., Karagiannis, Sophia N.

Publikováno v: Ilieva, K M, Fazekas-Singer, J, Achkova, D Y, Dodev, T S, Mele, S, Crescioli, S, Bax, H J, Cheung, A, Karagiannis, P, Correa, I, Figini, M, Marlow, R, Josephs, D H, Beavil, A J, Maher, J, Spicer, J F, Jensen-Jarolim, E, Tutt, A N & Karagiannis, S N 2017, ' Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields ', Frontiers in Immunology, vol. 8, no. SEP, 1112 . https://doi.org/10.3389/fimmu.2017.01112

Monoclonal antibodies find broad application as therapy for various types of cancer by employing multiple mechanisms of action against tumors. Manipulating the Fc-mediated functions of antibodies that engage immune effector cells, such as NK cells, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::804b34c33d171efcac50202eb59f5f8f
https://kclpure.kcl.ac.uk/ws/files/79472268/Functionally_Active_Fc_Mutant_ILIEVA_Accepted_21Aug2017_epub_11Sep2017_GOLD_VoR_CCBY.pdf

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields.

Autor: Ilieva KM; St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom.; Breast Cancer Now Unit, School of Cancer Sciences, Guy's Cancer Centre, King's College London, London, United Kingdom., Fazekas-Singer J; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, University of Vienna, Vienna, Austria.; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Achkova DY; School of Cancer Sciences, King's College London, Bermondsey Wing, Guy's Hospital, London, United Kingdom., Dodev TS; St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom.; Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, London, United Kingdom., Mele S; St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom., Crescioli S; St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom., Bax HJ; St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom., Cheung A; St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom.; Breast Cancer Now Unit, School of Cancer Sciences, Guy's Cancer Centre, King's College London, London, United Kingdom., Karagiannis P; St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom.; Department of Oncology, Haematology and Stem Cell Transplantation, University Hospital of Hamburg Eppendorf, Hamburg, Germany., Correa I; St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom., Figini M; Molecular Therapies Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori Milano, Milan, Italy., Marlow R; Breast Cancer Now Unit, School of Cancer Sciences, Guy's Cancer Centre, King's College London, London, United Kingdom., Josephs DH; St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom.; School of Cancer Sciences, King's College London, Bermondsey Wing, Guy's Hospital, London, United Kingdom., Beavil AJ; Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, London, United Kingdom., Maher J; School of Cancer Sciences, King's College London, Bermondsey Wing, Guy's Hospital, London, United Kingdom.; Department of Clinical Immunology and Allergy, King's College Hospital NHS Foundation Trust, London, United Kingdom.; Department of Immunology, Eastbourne Hospital, Eastbourne, United Kingdom., Spicer JF; School of Cancer Sciences, King's College London, Bermondsey Wing, Guy's Hospital, London, United Kingdom., Jensen-Jarolim E; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, University of Vienna, Vienna, Austria.; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Tutt AN; Breast Cancer Now Unit, School of Cancer Sciences, Guy's Cancer Centre, King's College London, London, United Kingdom., Karagiannis SN; St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom.; Breast Cancer Now Unit, School of Cancer Sciences, Guy's Cancer Centre, King's College London, London, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2017 Sep 11; Vol. 8, pp. 1112. Date of Electronic Publication: 2017 Sep 11 (Print Publication: 2017).