The branched chain amino acids (BCAAs) modulate the development of the intra-cellular stages of Trypanosoma cruzi.

Autor: Rapado LN; LaBTryps, Instituto de Ciencias Biomedicas II, Universidade de São Paulo, Av. Lineu Prestes 1374, Cidade Universitária Butanta, São Paulo, CEP 05508-900, Brazil., Nascimento JF; LaBTryps, Instituto de Ciencias Biomedicas II, Universidade de São Paulo, Av. Lineu Prestes 1374, Cidade Universitária Butanta, São Paulo, CEP 05508-900, Brazil., Manchola NC; LaBTryps, Instituto de Ciencias Biomedicas II, Universidade de São Paulo, Av. Lineu Prestes 1374, Cidade Universitária Butanta, São Paulo, CEP 05508-900, Brazil., Damasceno FS; LaBTryps, Instituto de Ciencias Biomedicas II, Universidade de São Paulo, Av. Lineu Prestes 1374, Cidade Universitária Butanta, São Paulo, CEP 05508-900, Brazil., Achjian RW; LaBTryps, Instituto de Ciencias Biomedicas II, Universidade de São Paulo, Av. Lineu Prestes 1374, Cidade Universitária Butanta, São Paulo, CEP 05508-900, Brazil., Silber AM; LaBTryps, Instituto de Ciencias Biomedicas II, Universidade de São Paulo, Av. Lineu Prestes 1374, Cidade Universitária Butanta, São Paulo, CEP 05508-900, Brazil. Electronic address: asilber@usp.br.

Publikováno v: Experimental parasitology [Exp Parasitol] 2023 Dec; Vol. 255, pp. 108642. Date of Electronic Publication: 2023 Nov 07.

How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell.

Autor: Nascimento JF; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-São Paulo, Brazil., Souza ROO; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-São Paulo, Brazil., Alencar MB; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-São Paulo, Brazil., Marsiccobetre S; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-São Paulo, Brazil., Murillo AM; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-São Paulo, Brazil., Damasceno FS; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-São Paulo, Brazil., Girard RBMM; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-São Paulo, Brazil., Marchese L; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-São Paulo, Brazil., Luévano-Martinez LA; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-São Paulo, Brazil., Achjian RW; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-São Paulo, Brazil., Haanstra JR; Systems Biology Lab, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Michels PAM; School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom., Silber AM; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-São Paulo, Brazil.

Publikováno v: PLoS pathogens [PLoS Pathog] 2023 Jul 27; Vol. 19 (7), pp. e1011522. Date of Electronic Publication: 2023 Jul 27 (Print Publication: 2023).