Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Achim Schmidtko"'
Autor:
Luisa D. Burgers, Sarah Ciurus, Patrick Engel, Silvia Kuntschar, Rebecca Raue, Anastasiia Kiprina, Tobias Primke, Tobias Schmid, Andreas Weigert, Achim Schmidtko, Robert Fürst
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116907- (2024)
The plant alkaloid homoharringtonine (HHT) is a Food and Drug Administration (FDA)-approved drug for the treatment of hematologic malignancies. In addition to its well-established antitumor activity, accumulating evidence attributes anti-inflammatory
Externí odkaz:
https://doaj.org/article/89e279c87cd2447e87409b0b0949985d
Autor:
Annika Balzulat, W. Felix Zhu, Cathrin Flauaus, Victor Hernandez‐Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Publikováno v:
Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)
Abstract Various disorders are accompanied by histamine‐independent itching, which is often resistant to the currently available therapies. Here, it is reported that the pharmacological activation of Slack (Kcnt1, KNa1.1), a potassium channel highl
Externí odkaz:
https://doaj.org/article/1458b733707e4809ab4a13b283445821
Autor:
Annemarie Aue, Nils Englert, Leon Harrer, Fabian Schwiering, Annika Gaab, Peter König, Ralf Adams, Achim Schmidtko, Andreas Friebe, Dieter Groneberg
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background The origin of αSMA-positive myofibroblasts, key players within organ fibrosis, is still not fully elucidated. Pericytes have been discussed as myofibroblast progenitors in several organs including the lung. Methods Using tamoxife
Externí odkaz:
https://doaj.org/article/e9747f2f4f6049e1ae3c401a0ffa0e35
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1162 (2022)
Inflammation or injury to the somatosensory nervous system may result in chronic pain conditions, which affect millions of people and often cause major health problems. Emerging lines of evidence indicate that reactive oxygen species (ROS), such as s
Externí odkaz:
https://doaj.org/article/7b7a4b7df476416bbba49701aa3fdf8c
Autor:
Fangyuan Zhou, Katharina Metzner, Patrick Engel, Annika Balzulat, Marco Sisignano, Peter Ruth, Robert Lukowski, Achim Schmidtko, Ruirui Lu
Publikováno v:
Cells, Vol 11, Iss 10, p 1693 (2022)
The transient receptor potential (TRP) ankyrin type 1 (TRPA1) channel is highly expressed in a subset of sensory neurons where it acts as an essential detector of painful stimuli. However, the mechanisms that control the activity of sensory neurons u
Externí odkaz:
https://doaj.org/article/3cb3270459a5471aaa1626696c99df05
Autor:
Sven Schmiedl, David Peters, Oliver Schmalz, Anke Mielke, Tanja Rossmanith, Shirin Diop, Martina Piefke, Petra Thürmann, Achim Schmidtko
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Neuropathic pain is a debilitating and commonly treatment-refractory condition requiring novel therapeutic options. Accumulating preclinical studies indicate that the potassium channel Slack (KNa1.1) contributes to the processing of neuropathic pain,
Externí odkaz:
https://doaj.org/article/5e950c5da33a4277b36e3480a2a12237
Autor:
Ruirui Lu, Katharina Metzner, Fangyuan Zhou, Cathrin Flauaus, Annika Balzulat, Patrick Engel, Jonas Petersen, Rebekka Ehinger, Anne Bausch, Peter Ruth, Robert Lukowski, Achim Schmidtko
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 405 (2021)
The sodium-activated potassium channel Slack (KNa1.1, Slo2.2, or Kcnt1) is highly expressed in populations of sensory neurons, where it mediates the sodium-activated potassium current (IKNa) and modulates neuronal activity. Previous studies suggest t
Externí odkaz:
https://doaj.org/article/2aa8eeb924674d3aac37da179a4c214a
Autor:
Tilman Gross, Gesine Wack, Katharina M. J. Syhr, Tanya Tolmachova, Miguel C. Seabra, Gerd Geisslinger, Ellen Niederberger, Achim Schmidtko, Wiebke Kallenborn-Gerhardt
Publikováno v:
Cells, Vol 9, Iss 6, p 1488 (2020)
Tissue injury and inflammation may result in chronic pain, a severe debilitating disease that is associated with great impairment of quality of life. An increasing body of evidence indicates that members of the Rab family of small GTPases contribute
Externí odkaz:
https://doaj.org/article/126b9a9a996b4adabf0cf92813466115
Autor:
Philip Tröster, Julia Haseleu, Jonas Petersen, Oliver Drees, Achim Schmidtko, Frederick Schwaller, Gary R. Lewin, Gohar Ter-Avetisyan, York Winter, Stefanie Peters, Susanne Feil, Robert Feil, Fritz G. Rathjen, Hannes Schmidt
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
A cGMP signaling cascade composed of C-type natriuretic peptide, the guanylyl cyclase receptor Npr2 and cGMP-dependent protein kinase I (cGKI) controls the bifurcation of sensory axons upon entering the spinal cord during embryonic development. Howev
Externí odkaz:
https://doaj.org/article/27326bdcde95470aba32eea6fe3c906d
Autor:
Stefanie Peters, Michael Paolillo, Evanthia Mergia, Doris Koesling, Lea Kennel, Achim Schmidtko, Michael Russwurm, Robert Feil
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2313 (2018)
Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl cyclase (NO-GC), of which two isoforms—NO-GC1 and NO-GC2—are known, represents a promising drug target to increase cGMP in the brain. Drug-like sm
Externí odkaz:
https://doaj.org/article/8760d61e1dae47d8953a4136e7e730ac