Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Achim Raap"'
Autor:
Jürgen Schloos, Iris Treinies, Michael Paal, Veikko Koivisto, Achim Raap, Hans-Jürgen Mest, Ulrich Giese
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 364:47-52
Sulfonylureas stimulate insulin secretion independent of the blood glucose concentration. This can lead to hypoglycaemia in type 2 diabetic patients. Over the last years a number of imidazoline derivatives have been identified that stimulate insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257e5ce1a8fca867cb3f5ac6e9345c9a
https://doi.org/10.1007/s002100100415
https://doi.org/10.1007/s002100100415
Publikováno v:
Heart Failure Reviews. 2:173-193
Congestive heart failure (CHF) is the most frequent cause of hospitalization in patients over 65. Hospitalized patients with severe CHF could benefit from new agents that directly support myocardial contractility and peripheral hemodynamics. The few
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9937ee3f0f604882c9efb97fd1c54863
https://doi.org/10.1023/a:1009712916873
https://doi.org/10.1023/a:1009712916873
Autor:
Martin C. Michel, Markus Steinfath, Michael Böhm, Boris Hertle, Hasso Scholz, Otto-Erich Brodde, Ulrike Mende, Andreas Pohl, Thomas Eschenhagen, Achim Raap, Matthias Diederich, Wilhelm Schmitz, Christian Memmesheimer
Publikováno v:
Circulation. 93:763-771
Background The present study investigated biochemical and functional consequences of chronic activation of the inhibitory G iα -coupled adenylyl cyclase pathway in the heart. Methods and Results Rats (220 to 260 g) were treated with 4-day infusions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fc187c41b8a08b726539848a2e3f63
https://doi.org/10.1161/01.cir.93.4.763
https://doi.org/10.1161/01.cir.93.4.763
Publikováno v:
Europe PubMed Central
The lipoxygenase inhibitor 2-phenylmethyl-1 -naphthol (DuP 654) has been shown to be an active anti-inflammatory drug in a murine skin inflammation model. Since 12-HETE is as-sumed to have a pathophysiological role in inflammatory skin diseases, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efc8dd65381f9cf752bcb2a802a8459
https://doi.org/10.1159/000211099
https://doi.org/10.1159/000211099
Autor:
David Monteith, Brian R. Berridge, Sanjay Bhanot, Aaron D. Showalter, Kyle W. Sloop, Julie S. Moyers, Lynnetta Watts, Robert Mckay, Martin B. Brenner, Achim Raap, M. Dodson Michael, Brett P. Monia, Amy L. Cox, Diane M. Bodenmiller, Owens Rebecca Anne, Julia Xiao-Chun Cao, Hong Yan Zhang, Niels Pørksen, Steven J. Jacobs, Angela M. Siesky, Jesper Gromada
Publikováno v:
The Journal of clinical investigation. 113(11)
Uncontrolled hepatic glucose production contributes significantly to hyperglycemia in patients with type 2 diabetes. Hyperglucagonemia is implicated in the etiology of this condition; however, effective therapies to block glucagon signaling and there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cca7d0fd54ce6e84c266e987effdec
https://pubmed.ncbi.nlm.nih.gov/15173883
https://pubmed.ncbi.nlm.nih.gov/15173883
Autor:
Alexander M. Efanov, Hans Juergen Mest, Sergei Zaitsev, Ioulia B. Appelskog, Per Olof Berggren, Olof Larsson, Achim Raap, Suad Efendic
Publikováno v:
Diabetes. 50(4)
The insulinotropic activity of the novel imidazoline compound BL11282 was investigated. Intravenous administration of BL11282 (0.3 mg · kg–1 · min–1) to anesthetized rats did not change blood glucose and insulin levels under basal conditions, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721993a3fb08d91edeb814df429391fe
https://pubmed.ncbi.nlm.nih.gov/11289044
https://pubmed.ncbi.nlm.nih.gov/11289044
Autor:
Achim Raap, Wolfgang Blechacz, Benjamin Armah, Jürgen Schloos, Hans-Jürgen Mest, Wolfgang Stenzel
Publikováno v:
Journal of cardiovascular pharmacology. 29(2)
The electromechanical and biochemical activities of the positive inotropic compounds BDF 9148 and DPI 201-106 were compared in guinea-pig myocardic preparations. Additionally, the properties of the BDF 9148 enantiomers were studied to compare their p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66783d30257246205e96d4685760907
https://pubmed.ncbi.nlm.nih.gov/9057064
https://pubmed.ncbi.nlm.nih.gov/9057064