Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Achim Moeller"'
Autor:
Achim Moeller
In 1944, Lyonel Feininger (1871–1956) wrote his first letter to fellow painter Mark Tobey (1890–1976) after seeing Tobey's first solo show at the Willard Gallery in New York. It was the beginning of a close friendship that lasted until Feininger'
Autor:
Marjoleen Nijsen, Wilfried Hornberger, Achim Moeller, Volker Nimmrich, Helmut Mack, Andreas Kling, Katja Jantos, Yanbin Lao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1968-1973
Aberrant activation of calpain has been observed in various pathophysiological disorders including neurodegenerative diseases such as Alzheimer's Disease. Here we describe our efforts on ketoamide-based 1-benzyl-5-oxopyrrolidine-2-carboxamides as a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d6b168db54ba67ccee056772963483
https://doi.org/10.1016/j.bmcl.2019.05.034
https://doi.org/10.1016/j.bmcl.2019.05.034
Autor:
Marjoleen Nijsen, Katja Jantos, Helmut Mack, Wilfried Hornberger, Achim Moeller, Andreas Kling, Gisela Backfisch, Yanbin Lao, Beatrice Rendenbach-Mueller
Publikováno v:
ACS Medicinal Chemistry Letters. 9:221-226
[Image: see text] Dysregulation of calpains 1 and 2 has been implicated in a variety of pathological disorders including ischemia/reperfusion injuries, kidney diseases, cataract formation, and neurodegenerative diseases such as Alzheimer’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bf1ef3c62188e81f6133eea6d3aaa4
https://doi.org/10.1021/acsmedchemlett.7b00494
https://doi.org/10.1021/acsmedchemlett.7b00494
Autor:
Wilfried Hornberger, Achim Moeller, Yanbin Lao, Kennan C. Marsh, Karla Drescher, Wicke Karsten, Andreas Kling, Ana Lucia Relo, Volker Nimmrich, Charles W. Hutchins, Katja Jantos, Helmut Mack
Publikováno v:
Journal of Medicinal Chemistry. 60:7123-7138
Calpain overactivation has been implicated in a variety of pathological disorders including ischemia/reperfusion injury, cataract formation, and neurodegenerative diseases such as Alzheimer's disease (AD). Herein we describe our efforts leading to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22512573f194ae025815e7aa3a15657
https://doi.org/10.1021/acs.jmedchem.7b00731
https://doi.org/10.1021/acs.jmedchem.7b00731
Autor:
Anton Bespalov, Achim Moeller, Rainer Spanagel, Wolfgang H. Sommer, Marcus W. Meinhardt, Patrick M. Beardsley, Valentina Vengeliene
Publikováno v:
Neuropsychopharmacology. 41:979-988
Preclinical studies revealed contribution of N-methyl-D-aspartate receptors (NMDARs) to a variety of neuropsychiatric diseases including alcoholism, but development of NMDAR antagonists for therapeutic use has been a challenge, in part due to severe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53bf6f345362ee8368d4a99ed5eff97e
https://doi.org/10.1038/npp.2015.225
https://doi.org/10.1038/npp.2015.225
Autor:
Adriana Ferreira, Robert S. Bitner, Achim Moeller, Roxana C. Sinjoanu, Sara Kleinschmidt, Jorge D. Brioni
Publikováno v:
Neurochemistry International. 53:79-88
We have previously shown that beta-amyloid (Abeta) oligomers induced dynamin 1 and tau cleavage in cultured hippocampal neurons. As a result of this cleavage, dynamin 1 levels decreased and a toxic tau fragment was generated. Abeta-induced cleavage o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddd0af46de3d6e01c7971495f306844
https://doi.org/10.1016/j.neuint.2008.06.003
https://doi.org/10.1016/j.neuint.2008.06.003
Autor:
Lynne E. Rueter, Achim Moeller, Martin Schmidt, Volker Nimmrich, Min Zhang, Elizabeth van der Kam, Sean C. Turner, Junli Ma, Jordan W. Brown
Publikováno v:
Neuropharmacology. 101
The GABA(B) receptor has been indicated as a promising target for multiple CNS-related disorders. Baclofen, a prototypical orthosteric agonist, is used clinically for the treatment of spastic movement disorders, but is associated with unwanted side-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1200a95eb1a41649098d370a55c118
https://pubmed.ncbi.nlm.nih.gov/26471422
https://pubmed.ncbi.nlm.nih.gov/26471422
Autor:
Labkovsky B, Achim Moeller, Tariq Ghayur, Devanarayan, Eve H. Barlow, Mario Mezler, Axel Meyer, Reinhold Mueller, Schmidt Mk, Norreel Jc, Mueller Bk
Publikováno v:
Journal of Neurological Disorders.
An insult to the mammalian spinal cord often results in persistent functional deficits. Proteins in CNS myelin are important determinants of this situation as they inhibit neurite growth. Among those proteins Nogo-A, oligodendrocyte myelin glycoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09cdedcfe253b8039c41bb7fccd84a46
https://doi.org/10.4172/2329-6895.1000128
https://doi.org/10.4172/2329-6895.1000128
Autor:
David Baglietto-Vargas, David Cheng, Achim Moeller, Andreas Kling, Rodrigo Medeiros, Frank M. LaFerla, Masashi Kitazawa, Meredith A. Chabrier, Kim N. Green
Publikováno v:
The American journal of pathology. 181(2)
Calpains are cysteine proteinases that selectively cleave proteins in response to calcium signals. Exacerbated activation of calpain has been implicated as a major component in the signaling cascade that leads to β-amyloid (Aβ) production and tau h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611bb227c6c40c53c0c4719dbb04bab6
https://pubmed.ncbi.nlm.nih.gov/22733009
https://pubmed.ncbi.nlm.nih.gov/22733009
Autor:
Gerhard Gross, Hans Schoemaker, Robert Szabo, Volker Nimmrich, Csaba Nyakas, Achim Moeller, Paul G.M. Luiten
Publikováno v:
Alzheimer's & Dementia. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04e23521187ebfd658b4a050bed26113
https://doi.org/10.1016/j.jalz.2008.05.1528
https://doi.org/10.1016/j.jalz.2008.05.1528