Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Achim K. Moesta"'
1
Akademický článek
Diverse functionality among NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3
Autor: Achim K. Moesta, Peter eParham
Publikováno v: Frontiers in Immunology, Vol 3 (2012)
Interactions between killer immunoglobulin-like receptors (KIRs) and their HLA-A, -B, and –C ligands diversify the functions of human natural killer cells. Consequently, combinations of KIR and HLA genotypes affect resistance to infection and autoi
Externí odkaz: https://doaj.org/article/50bb0193bef24f4e902d10639f7dae88
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2
Data from Control of Metastases via Myeloid CD39 and NK Cell Effector Function
Autor: Mark J. Smyth, Michele W.L. Teng, Nishamol Geetha, Achim K. Moesta, Courtney Beers, Simon C. Robson, Bianca Nowlan, Celia Jacoberger-Foissac, Christos Xiao, Amelia Roman Aguilera, Xian-Yang Li, Juming Yan
Natural killer (NK) cell protection from tumor metastases is a critical feature of the host immune response to cancer, but various immunosuppression mechanisms limit NK cell effector function. The ectoenzyme, CD39, expressed on tumor-infiltrating mye
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcb9aebe3a217277e6f16a5e7019c5b
https://doi.org/10.1158/2326-6066.c.6550408
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8
Targeting CD39 in cancer
Autor: Mark J. Smyth, Xian-Yang Li, Achim K. Moesta
Publikováno v: Nature Reviews Immunology. 20:739-755
The ATP-adenosine pathway functions as a key modulator of innate and adaptive immunity within the tumour microenvironment. Consequently, multiple clinical strategies are being explored to target this pathway for the treatment of cancer; in particular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caeb50fa003981347c14e4c2fd680892
https://doi.org/10.1038/s41577-020-0376-4
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9
698 Targeting HLA-G-mediated immunosuppression with a first-in-class antagonist antibody
Autor: Megan Welch, Jeffrey P. Jones, Christina M. Kochel, Douglas Hodges, Bradley N. Spatola, Courtney Beers, Michael Totagrande, John Corbin, Shelby Joe, Achim K. Moesta, Vanessa B. Soros
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Human leukocyte antigen-G (HLA-G) is an immune checkpoint molecule that belongs to the non-classical HLA-class I family of receptors. HLA-G restrains immune cell activation and effector function by engaging with inhibitory receptors ILT2 a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16321ac6f4c0778579bc5001d3e8d4d1
https://doaj.org/article/76655b5919884f7ea9aec25d1a4ffda6
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10
Akademický článek
Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells.
Autor: Laurent Abi-Rached, Achim K Moesta, Raja Rajalingam, Lisbeth A Guethlein, Peter Parham
Publikováno v: PLoS Genetics, Vol 6, Iss 11, p e1001192 (2010)
Natural killer (NK) cells serve essential functions in immunity and reproduction. Diversifying these functions within individuals and populations are rapidly-evolving interactions between highly polymorphic major histocompatibility complex (MHC) clas
Externí odkaz: https://doaj.org/article/bea9c052ea6c4e38b5c6b5aeef9a211f
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