Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Achim K, Moesta"'
Autor:
Mark J. Smyth, Michele W.L. Teng, Nishamol Geetha, Achim K. Moesta, Courtney Beers, Simon C. Robson, Bianca Nowlan, Celia Jacoberger-Foissac, Christos Xiao, Amelia Roman Aguilera, Xian-Yang Li, Juming Yan
Natural killer (NK) cell protection from tumor metastases is a critical feature of the host immune response to cancer, but various immunosuppression mechanisms limit NK cell effector function. The ectoenzyme, CD39, expressed on tumor-infiltrating mye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcb9aebe3a217277e6f16a5e7019c5b
https://doi.org/10.1158/2326-6066.c.6550408
https://doi.org/10.1158/2326-6066.c.6550408
Autor:
Mark J. Smyth, Michele W.L. Teng, Nishamol Geetha, Achim K. Moesta, Courtney Beers, Simon C. Robson, Bianca Nowlan, Celia Jacoberger-Foissac, Christos Xiao, Amelia Roman Aguilera, Xian-Yang Li, Juming Yan
Supplementary Figures 1-10 + Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa5c3e96c0c4470b1435ca89bb90362
https://doi.org/10.1158/2326-6066.22543801.v1
https://doi.org/10.1158/2326-6066.22543801.v1
Autor:
Mark J. Smyth, Michele W. L. Teng, Courtney Beers, Nishamol Geetha, Tobias Bald, Corey Smith, Nicola Waddell, Rebecca L. Johnston, Simon C. Robson, Michael Hölzel, Maike Effern, Ana C. Anderson, John Corbin, Vanessa B. Soros, Bradley N. Spatola, Alana G. Lerner, Megan Welch, Tracy dela Cruz, Clifford Wong, Celia Jacoberger-Foissac, Ashmitha Sundarrajan, Amelia Roman Aguilera, Ailin Lepletier, Jason Madore, Haiyan Zhang, Mika Casey, Kyohei Nakamura, Christos Xiao, Achim K. Moesta, Xian-Yang Li
We explored the mechanism of action of CD39 antibodies that inhibit ectoenzyme CD39 conversion of extracellular ATP (eATP) to AMP and thus potentially augment eATP–P2-mediated proinflammatory responses. Using syngeneic and humanized tumor models, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030175f55343048c09aeca7a10f290c0
https://doi.org/10.1158/2159-8290.c.6548314.v1
https://doi.org/10.1158/2159-8290.c.6548314.v1
Autor:
Mark J. Smyth, Michele W. L. Teng, Courtney Beers, Nishamol Geetha, Tobias Bald, Corey Smith, Nicola Waddell, Rebecca L. Johnston, Simon C. Robson, Michael Hölzel, Maike Effern, Ana C. Anderson, John Corbin, Vanessa B. Soros, Bradley N. Spatola, Alana G. Lerner, Megan Welch, Tracy dela Cruz, Clifford Wong, Celia Jacoberger-Foissac, Ashmitha Sundarrajan, Amelia Roman Aguilera, Ailin Lepletier, Jason Madore, Haiyan Zhang, Mika Casey, Kyohei Nakamura, Christos Xiao, Achim K. Moesta, Xian-Yang Li
Supplementary Methods, Figures, Legends and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d59e57662c63e9b64230b5f2cdb85d0
https://doi.org/10.1158/2159-8290.22537072.v1
https://doi.org/10.1158/2159-8290.22537072.v1
Autor:
Pedro J. Beltran, Courtney Beers, Rafael Ponce, Andrea M. Boden, David H. Cordover, Kenneth Ganley, Charles Glaus, Kim Merriam, Oluwatayo F. Ikotun, Brian Belmontes, Tiep Le, Becky Yang, Jinghui Zhan, Karen Fitzgerald, James B. Rottman, Petia Mitchell, Julia Piasecki, Keegan Cooke, Achim K. Moesta
Supp Figures S1 to S6 and Supp Tables S1 to S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503f6582b7cb25df46e86a0d409ba0b5
https://doi.org/10.1158/1078-0432.22463246
https://doi.org/10.1158/1078-0432.22463246
Autor:
Pedro J. Beltran, Courtney Beers, Rafael Ponce, Andrea M. Boden, David H. Cordover, Kenneth Ganley, Charles Glaus, Kim Merriam, Oluwatayo F. Ikotun, Brian Belmontes, Tiep Le, Becky Yang, Jinghui Zhan, Karen Fitzgerald, James B. Rottman, Petia Mitchell, Julia Piasecki, Keegan Cooke, Achim K. Moesta
Purpose: Talimogene laherparepvec, a new oncolytic immunotherapy, has been recently approved for the treatment of melanoma. Using a murine version of the virus, we characterized local and systemic antitumor immune responses driving efficacy in murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290bbe6502f2d8ee72ab096276248d16
https://doi.org/10.1158/1078-0432.c.6525350.v1
https://doi.org/10.1158/1078-0432.c.6525350.v1
Publikováno v:
Nature Reviews Immunology. 20:739-755
The ATP-adenosine pathway functions as a key modulator of innate and adaptive immunity within the tumour microenvironment. Consequently, multiple clinical strategies are being explored to target this pathway for the treatment of cancer; in particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caeb50fa003981347c14e4c2fd680892
https://doi.org/10.1038/s41577-020-0376-4
https://doi.org/10.1038/s41577-020-0376-4
Autor:
Megan Welch, Jeffrey P. Jones, Christina M. Kochel, Douglas Hodges, Bradley N. Spatola, Courtney Beers, Michael Totagrande, John Corbin, Shelby Joe, Achim K. Moesta, Vanessa B. Soros
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Human leukocyte antigen-G (HLA-G) is an immune checkpoint molecule that belongs to the non-classical HLA-class I family of receptors. HLA-G restrains immune cell activation and effector function by engaging with inhibitory receptors ILT2 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16321ac6f4c0778579bc5001d3e8d4d1
https://doaj.org/article/76655b5919884f7ea9aec25d1a4ffda6
https://doaj.org/article/76655b5919884f7ea9aec25d1a4ffda6
Autor:
Achim K. Moesta, Peter eParham
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
Interactions between killer immunoglobulin-like receptors (KIRs) and their HLA-A, -B, and –C ligands diversify the functions of human natural killer cells. Consequently, combinations of KIR and HLA genotypes affect resistance to infection and autoi
Externí odkaz:
https://doaj.org/article/50bb0193bef24f4e902d10639f7dae88
Publikováno v:
PLoS Genetics, Vol 6, Iss 11, p e1001192 (2010)
Natural killer (NK) cells serve essential functions in immunity and reproduction. Diversifying these functions within individuals and populations are rapidly-evolving interactions between highly polymorphic major histocompatibility complex (MHC) clas
Externí odkaz:
https://doaj.org/article/bea9c052ea6c4e38b5c6b5aeef9a211f