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Akademický článek

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

Autor: Jennifer Jung, Arnab Nayak, Véronique Schaeffer, Tatjana Starzetz, Achim K Kirsch, Stefan Müller, Ivan Dikic, Michel Mittelbronn, Christian Behrends

Publikováno v: eLife, Vol 6 (2017)

Autophagy is an intracellular recycling and degradation pathway that depends on membrane trafficking. Rab GTPases are central for autophagy but their regulation especially through the activity of Rab GEFs remains largely elusive. We employed a RNAi s

Externí odkaz: https://doaj.org/article/2b3fd1a808ea41678f73f158104a97b9

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Akademický článek

Diverse functionality among NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3

Autor: Achim K. Moesta, Peter eParham

Publikováno v: Frontiers in Immunology, Vol 3 (2012)

Interactions between killer immunoglobulin-like receptors (KIRs) and their HLA-A, -B, and –C ligands diversify the functions of human natural killer cells. Consequently, combinations of KIR and HLA genotypes affect resistance to infection and autoi

Externí odkaz: https://doaj.org/article/50bb0193bef24f4e902d10639f7dae88

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Akademický článek

Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells.

Autor: Laurent Abi-Rached, Achim K Moesta, Raja Rajalingam, Lisbeth A Guethlein, Peter Parham

Publikováno v: PLoS Genetics, Vol 6, Iss 11, p e1001192 (2010)

Natural killer (NK) cells serve essential functions in immunity and reproduction. Diversifying these functions within individuals and populations are rapidly-evolving interactions between highly polymorphic major histocompatibility complex (MHC) clas

Externí odkaz: https://doaj.org/article/bea9c052ea6c4e38b5c6b5aeef9a211f

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