Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Achim Goepferich"'
Autor:
Sara Maslanka Figueroa, Daniel Fleischmann, Sebastian Beck, Philipp Tauber, Ralph Witzgall, Frank Schweda, Achim Goepferich
Publikováno v:
Advanced Science, Vol 7, Iss 11, Pp n/a-n/a (2020)
Abstract Poor drug availability in the tissue of interest is a frequent cause of therapy failure. While nanotechnology has developed a plethora of nanocarriers for drug transport, their ability to unequivocally identify cells of interest remains mode
Externí odkaz:
https://doaj.org/article/d6a20a927b644e95865036ed969b73b7
Autor:
Raphael Mietzner, Ramona Pawlak, Ernst R. Tamm, Achim Goepferich, Rudolf Fuchshofer, Miriam Breunig
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 18 (2021)
A root cause for the development and progression of primary open-angle glaucoma might be the loss of the Schlemm’s canal (SC) cell function due to an impaired Angiopoietin-1 (Angpt-1)/Tie2 signaling. Current therapeutic options fail to restore the
Externí odkaz:
https://doaj.org/article/13ba8a624b6942ba8a42e5fce7a9f52b
Autor:
Daniel Fleischmann, Manuela Harloff, Sara Maslanka Figueroa, Jens Schlossmann, Achim Goepferich
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2557 (2021)
Diabetic nephropathy (DN) ranks among the most detrimental long-term effects of diabetes, affecting more than 30% of all patients. Within the diseased kidney, intraglomerular mesangial cells play a key role in facilitating the pro-fibrotic turnover o
Externí odkaz:
https://doaj.org/article/4fbf4a3a8a2f4231b354510002bc2842
Autor:
Leonie Herrnberger, Robert Hennig, Werner Kremer, Claus Hellerbrand, Achim Goepferich, Hans Robert Kalbitzer, Ernst R Tamm
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115005 (2014)
Liver sinusoidal endothelial cells (LSEC) are characterized by the presence of fenestrations that are not bridged by a diaphragm. The molecular mechanisms that control the formation of the fenestrations are largely unclear. Here we report that mice,
Externí odkaz:
https://doaj.org/article/8890371712a54cabb260f3d011ab54ab
Autor:
Oliver Zimmer, Achim Goepferich
Publikováno v:
Nanoscale Horizons. 8:256-269
The paramount relevance of clathrin-coated pits (CCPs) to receptor-mediated endocytosis of nanoparticles, extracellular vesicles, and viruses has made them the focus of many studies; however, the role of CCP geometry in the ligand–receptor interact
Publikováno v:
Drug Discovery Today. 27:2497-2509
The retinal pigment epithelium (RPE) plays a crucial part in sight-threatening diseases. In this review, we shed light on the pivotal implication of the RPE in age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity; and
Publikováno v:
Drug Delivery and Translational Research
Inflammation and immune system activation are key pathologic events in the onset and escalation of diabetic retinopathy (DR). Both are driven by cytokines and complement originating from the retinal pigment epithelium (RPE). Despite the RPE's pivotal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5d1f37c04dc5524e5a1ad39565fd94
Publikováno v:
Biomacromolecules. 22:3223-3236
Off-target interactions between reactive hydrogel moieties and drug cargo as well as slow reaction kinetics and the absence of controlled protein release over an extended period of time are major drawbacks of chemically cross-linked hydrogels for bio
Autor:
Marilena Bohley, Andrea E. Dillinger, Frank Schweda, Andreas Ohlmann, Barbara M. Braunger, Ernst R. Tamm, Achim Goepferich
Publikováno v:
Science advances. 8(38)
Retinopathy of prematurity (ROP) is a retinal disease that threatens the vision of prematurely born infants. Severe visual impairment up to complete blindness is caused by neovascularization and inflammation, progressively destroying the immature ret
Publikováno v:
Journal of Controlled Release. 333:536-559
Atherosclerosis is the leading cause of death in developed countries. The pathogenetic mechanism relies on a macrophage-based immune reaction to low density lipoprotein (LDL) deposition in blood vessels with dysfunctional endothelia. Thus, atheroscle